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  • 陈帅

教授,南京大学模式动物研究所

地址:南京大学浦口校区,南京市浦口区学府路12号,210061

邮箱:chenshuai@nju.edu.cn










研究领域


代谢性信号感知与转导

代谢疾病模型与机理

代谢疾病靶点发现与药物研发



工作经历


2012-至今,教授, 南京大学模式动物研究所        

2008-2011,Career Development Fellow, 英国邓迪大学/英国医学研究理事会蛋白磷酸化研究所



荣誉奖励


2020年,中国国家自然科学基金委杰出青年基金

2013年,教育部新世纪优秀人才计划

2008-2011年度,Career Development Fellowship,英国医学研究理事会



学术任职


2021-2024中国生物物理学会代谢生物学分会副会长

2019至今 中国细胞生物学学会细胞代谢分会副会长

2019至今 江苏省细胞与发育生物学学会副会长

2018至今 江苏省动物学会副会长

2020至今《遗传》副主编

2022至今《Life Metabolism》编委




代表性成果

1. Quan C, Zhu SS, Wang RZ, Chen JM, Chen QL, Li M, Su S, Du Q, Liu MJ, Wang HY* and Chen S* (2022) Impaired SERCA2a phosphorylation causes diabetic cardiomyopathy through impinging on cardiac contractility and precursor protein processing. Life Metabolism DOI: 10.1093/lifemeta/loac013 (* corresponding authors)

2. Zhu SS, Quan C, Wang RZ, Liang DR, Su S, Rong P, Zhou K, Yang XY, Chen QL, Li M, Du Q, Zhang JZ, Fang L, Wang HY* and Chen S* (2022) The RalGAPα1−RalA signal module protects cardiac function through regulating calcium homeostasis. Nat Commun 13: 4278 DOI: 10.1038/s41467-022-31992-z (* corresponding authors)

3. Wei W, Chen QL, Liu MJ, Sheng Y, OuYang Q, Feng WK, Yang XY, Ding LF, Su S, Zhang JZ, Fang L, Vidal-Puig A, Wang HY* and Chen S* (2022) TRIM24 is an insulin-responsive regulator of P-bodies. Nat Commun 13: 3972 DOI: 10.1038/s41467-022-31735-0 (* corresponding authors)

4. Zhou K, Chen QL, Chen JM, Liang DR, Feng WK, Liu MJ, Wang Q, Wang RZ, OuYang Q, Quan C* and Chen S*(2022) Spatiotemporal regulation of insulin signaling by liquid-liquid phase separation. Cell Discov 8(1): 64 DOI: 10.1038/s41421-022-00430-1 (* corresponding authors)

5. Chen ZY, Sun YT, Wang ZM, Hong J, Xu M, Zhang FT, Zhou XQ, Rong P, Wang Q, Wang HY, Wang H*, Chen S*and Chen L* (2022) Rab2A regulates the progression of nonalcoholic fatty liver disease downstream of AMPK-TBC1D1 axis by stabilizing PPARg. Plos Biol 20(1): e3001522 DOI: 10.1371/journal.pbio.3001522 (* corresponding authors)

6. Yang XY, Chen QL, OuYang Q, Rong P, Feng WK, Quan C, Li M, Jiang Q, Liang H, Zhao TJ, Wang HY* and Chen S*. (2021) Tissue-specific splicing and dietary interaction of a mutant As160 allele determine muscle metabolic fitness in rodents. Diabetes doi: 10.2337/db21-0039(* corresponding author)

7. Quan C, Du Q, Li M, Wang RZ, Su S, Zhu SS, Chen QL, Sheng Y, Chen L, Wang H, Campbell DG, MacKintosh C, Yang ZZ, Ouyang KF, Wang HY* and Chen S* (2020) A PKB-SPEG signaling nexus links insulin resistance with diabetic cardiomyopathy by regulating calcium homeostasis. Nat Commun 11(1): 2186 doi: 10.1038/s41467-020-16116-9 (* corresponding author)

8. Hao JW, Wang J, Guo HL, Zhao YY, Sun HH, Li YF, Lai XY, Zhao N, Wang X, Xie CC, Hong LX, Huang X, Wang HR, Li CB, Liang B, Chen S* and Zhao TJ* (2020) CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis. Nat Commun 11(1): 4765 doi: 10.1038/s41467-020-18565-8 (* corresponding author)

9. Chen QL, Rong P, Zhu SS, Yang XY, Ouyang Q, Wang HY and Chen S* (2019) Targeting RalGAPα1 in skeletal muscle to simultaneously improve postprandial glucose and lipid control. Science Advances 5(4): eaav4116 (* corresponding author)

10. Quan C, Li M, Du Q, Chen QL, Wang H, Campbell D, Fang L, Xue B, MacKintosh C, Gao X, Ouyang KF, Wang HY and Chen S* (2019) SPEG controls calcium re-uptake into the sarcoplasmic reticulum through regulating SERCA2a by its second kinase-domain. Circ Res 124(5): 712-726 (* corresponding author)

11. Kang D, Wang D, Xu J, Quan C, Guo X, Wang H, Luo J, Yang Z, Chen S*, Chen J*. (2018) The InR/Akt/TORC1 Growth-Promoting Signaling Negatively Regulates JAK/STAT Activity and Migratory Cell Fate during Morphogenesis. Dev Cell 44:524-531 e525 (* corresponding author)

12. Chen Q, Rong P, Xu D, Zhu S, Chen L, Xie B, Du Q, Quan C, Sheng Y, Zhao TJ, Li P, Wang HY*Chen S* (2017) Rab8a deficiency in skeletal muscle causes hyperlipidemia and hepatosteatosis by impairing muscle lipid uptake and storage. Diabetes 66(9): 2387-2399 (* corresponding author)

13. Chen QL, Xie BX, Zhu SS, Rong P, Sheng Y, Ducommun S, Chen L, Quan C, Li M, Sakamoto K, MacKintosh C, Chen S* and Wang HY* (2017) A TBC1D1Ser231Ala knockin mutation partially impairs 5-aminoimidazole-4-carboxamide-1-ß-D-ribofuranoside- but not exercise-induced muscle glucose uptake in mice. Diabetologia 60(2): 336-345(* corresponding author)

14. Xie B.X., Chen Q.L., Chen L., Sheng Y., Wang H.Y.* and Chen S.* (2016) The inactivation of RabGAP function of AS160 promotes lysosomal degradation of GLUT4 and causes postprandial hyperglycemia and hyperinsulinemia. Diabetes 65(11):3327-3340 (* corresponding author)

15. Chen L., Chen Q.L., Xie B.X., Quan C., Sheng Y., Zhu S.S., Rong P., Zhou S.L., Sakamoto K., MacKintosh C., Wang H.Y. * and Chen S.*(2016) Disruption of the AMPK–TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion. PNAS 113(26): 7219-24 (* corresponding author)

16. Li M., Quan C., Toth R., Campbell D.G., MacKintosh C.*, Wang H.Y.* and Chen S.* (2015) Fasting and systemic insulin signaling regulate phosphorylation of brain proteins that modulate cell morphology and link to neurological disorders. J Biol. Chem. 290(50):30030-41 (corresponding author)

17. Chen Q.L., Quan C., Xie B.X., Chen L., Zhou S.L., Toth R., Campbell D.G., Lu S.S., Shirakawa R., Horiuchi H., Li C.J., Yang Z.Z., MacKintosh C., Wang H.Y.* and Chen S.*.  (2014) GARNL1, a major RalGAP a subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins. Cell Signal 26(8): 1636-1648 (* corresponding author)

18. Wang H.Y., Ducommun S., Quan C., Xie B.X., Li M., Wasserman D.H., Sakamoto K., MacKintosh C.* and Chen S.*(2013) AS160 deficiency causes whole-body insulin resistance via composite effects in multiple tissues. Biochem J. 449 (2): 479-489 (corresponding author)

19. Chen S, Synowsky S, Tinti M and MacKintosh C (2011) The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin. Trends Endocrinol Metab 22(11):429-36

20. Chen S*, Wasserman D, MacKintosh C and Sakamoto K (2011) Mice with AS160/TBC1D4 Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking. Cell Metabolism 13(1): 68-79 (corresponding author)


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