教授,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:chenguiquan@nju.edu.cn
研究领域 |
神经发育疾病及神经退行疾病
工作经历 |
2012-,南京大学博士生导师
2012-,南京大学教授
荣誉奖励 |
2012,江苏省“创新创业”人才
代表性成果 |
1. Xia Y, Zhang Y, Xu M, Zou X, Gao J, Ji M, Chen G. Presenilin enhancer2 is crucial for the transition of apical progenitors into neurons but into not basal progenitors in the developing hippocampus. Development 2022 (149):dev.200272.
2. Ye X, Chen L, Wang H, Peng, S, Liu M, Yao L, Zhang Y, Shi Y, Cao Y, Yang J, Chen G. Genetic inhibition of PDK1 robustly reduces plaque deposition and ameliorates gliosis in the 5×FAD mouse model of Alzheimer's disease. Neuropathology and Applied Neurobiology 2022: e12839.
3. Teng X, Hu P, Chen Y, Zang Y, Ye X, Ou J, Chen G, Shi YS. A novel Lgi1 mutation causes white matter abnormalities and impairs motor coordination in mice. FASEB Journal 2022 (36):e22212.
4. Wang H, Liu M, Ye Z, Zhou C, Bi H, Wang L, Zhang C, Fu H, Shen Y, Yang J, Hu Y, Chen G. Akt regulates Sox10 expression to control oligodendrocyte differentiation via phosphorylating FoxO1. Journal of Neuroscience 2021 (41): 8163-8180.
5. Hou J, Bi H, Ye Z, Huang W, Zou G, Zou X, Shi Y, Shen Y, Ma Q, Kirchhoff F, Hu Y, Chen G. Pen-2 negatively regulates the differentiation of oligodendrocyte precursor cells into astrocytes in the central nervous system. Journal of Neuroscience 2021 (41):4976-4990.
6. Wang H,Liu M,Zou G,Wang L, Duan W,He X, Ji M,Zou X, Hu Y, Yang J, Chen G. Deletion of PDK1 in oligodendrocyte lineage cells causes white matter abnormality and myelination defect in the central nervous system. Neurobiology of Disease 2021 (148): 105212.
7. Bi H,Zhou C,Zhang Y,Cai X,Ji M,Yang J,Chen G, Hu Y. Neuron-specific deletion of presenilin enhancer2 causes progressive astrogliosis and agerelated neurodegeneration in the cortex independent of the Notch signaling. CNS Neuroscience & Therapeutics 2021 (27): 174-185.
8. Ma X, Wang Y, Hua J, Xu C, Yang T, Yuan J, Chen G, Guo Z and Wang X. Aβ-sheet-targeted theranostic agent for diagnosing and preventing aggregation of pathogenic peptides in Alzheimer’s disease (Cover story). Science China Chemistry 2020 (63):73-82.
9. Huang C, Liu T, Wang Q, Hou W, Zhou C, Song Z, Shi YS, Gao X, Chen G, Yin Z and Hu Y. Loss of PP2A disrupts the retention of radial glial progenitors in the telencephalic niche to impair the generation of late-born neurons during cortical development (Cover story). Cerebral Cortex 2020 (30):4183-4196.
10. Cheng S, Liu T, Hu Y, Xia Y, Hou J, Huang C, Zou X, Shi Y, Zheng Y, Lu J and Chen G. Conditional inactivation of Pen-2 in the developing neocortex leads to rapid switch of apical progenitors to basal progenitors. Journal of Neuroscience 2019 (39):2195-2207.
团队风采 |