教授、博导、南京大学生命科学学院副院长
地址:南京市栖霞区仙林大道163号,210023
邮箱:leidong@nju.edu.cn
研究领域 |
近期研究主要围绕生物材料、组织工程与再生医学、肿瘤发病机制与创新治疗技术展开。研究重点是材料的生物活性来源、材料与生物系统的相互作用机制,以及通过材料对生物学过程进行精准调控的技术方法;发展全新策略来解决大型复杂器官的功能性再生与再造问题;整合合成生物学与组织工程技术原理与方法,进行器官级的生物功能合成;探索影响肿瘤发生于发展的关键机制,发展可直接或间接调控免疫的新材料、新方法和潜在药物,用于肿瘤的免疫治疗。
工作经历 |
1999-2003 南京大学生命科学学院 学士(生物技术)
2003-2007 南京大学生命科学学院 博士(生物化学与分子生物学)
2007-2009 南京大学化学化工学院 博士后(高分子)
2010-2012 南京大学生命科学学院 副教授
2013-至今 南京大学生命科学学院 教授
荣誉奖励 |
2021年荣获“长江学者奖励计划”特聘教授
2017年荣获江苏省杰出青年科学基金资助
2014年入选教育部“新世纪优秀人才支持计划”
学术任职 |
国家创伤医学中心器官保护专业委会委员
教育部病毒学教学资源建设项目专家
中国细胞生物学会第一、二届青年委员会委员
Chinese Medicine 编委
代表性成果 |
[1] C. Liu, L. Wang, M. Xu, Y. Sun, Z. Xing, J. Zhang, C. Wang, & L. Dong. Reprogramming the spleen into a functioning 'liver' in vivo. Gut. (2022). gutjnl-2021-325018.
[2] Z. Wang, Z. Zhai, C. Chen, X. Tian, Z. Xing, P. Xing, Y. Yang, J. Zhang, C. Wang, & L. Dong. Air pollution particles hijack peroxidasin to disrupt immunosurveillance and promote lung cancer. eLife, 11. (2022) e75345.
[3] Y. Wang, J. Pang, Q. Wang, L. Yan, L. Wang, Z. Xing, C. Wang, J. Zhang, & L. Dong. Delivering Antisense Oligonucleotides across the Blood‐Brain Barrier by Tumor Cell‐Derived Small Apoptotic Bodies. Advanced Science. 8(13). (2021) 2004929.
[4] X. Sun, J. Xiang, R. Chen, Z. Geng, L. Wang, Y. Liu, S. Ji, H. Chen, Y. Li, C. Zhang, P. Liu, T. Yue, L. Dong, & X. Fu. Sweat Gland Organoids Originating from Reprogrammed Epidermal Keratinocytes Functionally Recapitulated Damaged Skin. Adv Sci, 8(22). (2021) e2103079.
[5] R. Mu, Y. Zhang, L. Yan, Z. Liao, Y. Yang, H. Su, L. Dong, & C. Wang. A "Bridge-Building" Glycan Scaffold Mimicking Microbial Invasion for In Situ Endothelialization. Advanced materials (Deerfield Beach, Fla), 33(42). (2021) e2103490.
[6] C. Han, J. Song, J. Hu, H. Fu, Y. Feng, R. Mu, Z. Xing, Z. Wang, L. Wang, J. Zhang, C. Wang, & L. Dong. Smectite promotes probiotic biofilm formation in the gut for cancer immunotherapy. Cell Rep, 34(6). (2021) 108706.
[7] L. Wang, C. Wang, Z. Wang, J. Gan, C. Liu, S. Xia, Y. Niu, D. Chen, J. Zhang, & L. Dong. Transforming the spleen into a liver-like organ in vivo. Science Advances, 6(24). (2020) eaaz9974.
[8] W. He, J. Xu, R. Mu, Q. Li, D.-l. Lv, Z. Huang, J. Zhang, C. Wang, & L. Dong. High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation. Nat Commun, 11(1). (2020) 1732.
[9] S. Liu, Z. Wang, X. Jiang, J. Gan, X. Tian, Z. Xing, Y. Yan, J. Chen, J. Zhang, C. Wang, & L. Dong. Denatured corona proteins mediate the intracellular bioactivities of nanoparticles via the unfolded protein response. Biomaterials, 265. (2021) 120452.
[10] Z. Wang, Y. Niu, X. Tian, N. Yu, X. Yin, Z. Xing, Y. Li, L. Dong, & C. Wang. Switching On and Off Macrophages by a “Bridge‐Burning”Coating Improves Bone‐Implant Integration under Osteoporosis. Advanced Functional Materials. (2020) 2007408.
[11] Z. Wang, X. Rui, J. Qiu, Y. Yan, J. Gan, S. Liu, L. Wang, J. Zhang, C. Wang, & L. Dong. Growing Trans-Species Islets in Tumor Extract-Remodeled Testicles. Advanced Science, 6(6). (2019) 1801694.
[12] Y. M. Niu, Q. Li, Y. Ding, L. Dong, & C. M. Wang. Engineered delivery strategies for enhanced control of growth factor activities in wound healing. Adv Drug Deliv Rev, 146. (2019) 190-208.
[13] J. Gan, C. Liu, H. Li, S. Wang, Z. Wang, Z. Kang, Z. Huang, J. Zhang, C. Wang, D. Lv, & L. Dong. Accelerated wound healing in diabetes by reprogramming the macrophages with particle-induced clustering of the mannose receptors. Biomaterials, 219. (2019) 119340.
[14] Y. Feng, R. Mu, Z. Wang, P. Xing, J. Zhang, L. Dong, & C. Wang. A toll-like receptor agonist mimicking microbial signal to generate tumor-suppressive macrophages. Nature Communications, 10(1). (2019) 2272.
[15] Z. Wang, C. Wang, A. Abudukeremu, X. Rui, S. Liu, X. Zhang, M. Zhang, J. Zhang, & L. Dong. Engineering a Tumor Microenvironment-Mimetic Niche for Tissue Regeneration with Xenogeneic Cancer Cells. Advanced Science, 5(3). (2018) 1700666.
[16] C. Wang, Z. Wang, & L. Dong. Translating Current Bioanalytical Techniques for Studying Corona Activity. Trends in Biotechnology, 36(7). (2018) 661-672.
[17] Y. Shi, L. Wang, Y. Niu, N. Yu, P. Xing, L. Dong, & C. Wang. Fungal Component Coating Enhances Titanium Implant-Bone Integration. Advanced Functional Materials, 28(46). (2018)
[18] J. J. Gan, Y. Y. Dou, Y. R. Li, Z. Z. Wang, L. T. Wang, S. Liu, Q. Li, H. R. Yu, C. Y. Liu, C. W. Han, Z. Huang, J. F. Zhang, C. M. Wang, & L. Dong. Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors. Biomaterials, 178. (2018) 95-108.
[19] Z. Wang, C. Wang, S. Liu, W. He, L. Wang, J. Gan, Z. Huang, Z. Wang, H. Wei, J. Zhang, & L. Dong. Specifically Formed Corona on Silica Nanoparticles Enhances Transforming Growth Factor beta 1 Activity in Triggering Lung Fibrosis. ACS Nano, 11(2). (2017) 1659-1672.
[20] Y. Niu, Q. Li, R. Xie, S. Liu, R. Wang, P. Xing, Y. Shi, Y. Wang, L. Dong, & C. Wang. Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: Design of a glucomannan coating material. Biomaterials, 139. (2017) 39-55.
团队风采 |
其他 |
近五年主持的重大科研项目
1. 国家自然科学基金委员会,重点项目,32230056,复杂器官与组织在脾脏内的功能性再生,2023-2027,272 万元,主持;
2. 国家自然科学基金委员会,国际(地区)合作与交流项目,31961160701,设计可重塑组织微环境的生物材料支持异种肝组织的脾脏内再生,2020-2022,132 万元,主持;
3. 国家自然科学基金委员会,面上项目,81973273,蛋白冠状物介导可吸入颗粒物促进肺癌发生的活性机制研究,2020-2023,59万,主持;
4. 国家自然科学基金委员会,面上项目,81673380,蛋白冠状物在SiO2纳米微粒诱发矽肺病过程中的作用机制研究,2017-2020,62万,结题、主持;
5. 江苏省自然科学基金委员会,杰出青年基金项目,BK20170015,基于蛋白冠状物的核酸药物递释系统与机体相互作用研究,100万,2017-2020,结题、主持;
6. 教育部“新世纪优秀人才支持计划”,2014-2016,50万元,结题、主持;
7. 国家自然科学基金面上项目,阳离子聚合物特异性活化Th1免疫反应用于肿瘤的免疫治疗研究,2013-2016,80万元,结题、主持;
8. 南京大学“登峰人才支持计划”,2013-2016,100万元,结题、主持。