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  • 甘振继

教授,医药生物技术国家重点实验室 

地址:南京市栖霞区仙林大道163号,210023

邮箱:ganzj@nju.edu.cn








研究领域


线粒体,骨骼肌,代谢疾病分子机制




工作经历


2013-2015,南京大学模式动物研究所副教授

2015-2018,南京大学模式动物研究所教授

2018-2021,南京大学模式动物研究所教授、副所长

2021-至今,南京大学医学院模式动物研究所教授



荣誉奖励


2011, 美国心脏学会(AHA)博士后奖

2012, 美国心脏学会 Katz基础研究青年学者奖(Louis N. and Arnold M. Katz Basic Science Research Prize for Young Investigator)

2015, 国家级海外青年人才计划获得者

2016, 江苏省“双创人才”

2017, 江苏省“杰出青年”

2019, 国家基金委“优青”



学术任职


中国生物物理学会代谢生物学分会青年理事秘书长

中国病理生理学会内分泌与代谢分会副秘书长

中国细胞生物学学会细胞代谢分会理事

中国生物物理学会线粒体生物学分会理事

中国细胞生物学学会细胞结构与细胞行为分会理事

中国生化与分子生物学学会代谢分会理事

J Clin Invest.Nat Commun.Cell Death Differ.J Cachexia Sarcopenia Muscle.AutophagyAging CellEMBO RepFASEB J. 等学术期刊审稿




代表性成果

1. Guo Q#, Xu Z#, Zhou D, Fu T, Wang W, Sun W, Xiao L, Liu L, Ding C, Yin Y, Zhou Z, Sun Z, Zhu Y, Zhou W, Jia Y, Xue J, Chen Y, Chen XW, Piao HL, Lu B, Gan Z*. Mitochondrial proteostasis stress in muscle drives a long-range protective response to alleviate dietary obesity independently of ATF4. Science Advances. 2022; 8(30): eabo0340.

原文链接:https://www.science.org/doi/10.1126/sciadv.abo0340

2. Yin Y#, Xu D#, Mao Y#, Xiao L, Sun Z, Liu J, Zhou D, Xu Z, Liu L, Fu T, Ding C, Guo Q, Sun W, Zhou Z, Yang L, Jia Y, Chen X, Gan Z*. FNIP1 regulates white adipose tissue browning and systemic glucose homeostasis by shaping intracellular calcium dynamics. J Exp Med. 2022; 219(5): e20212491.

原文链接:https://rupress.org/jem/article-pdf/219/5/e20212491/1431340/jem_20212491.pdf

3. Xu Z#, Fu T#, Guo Q#, Zhou D, Sun W, Zhou Z, Chen X, Zhang Z, Liu L, Xiao L, Yin Y, Jia Y, Pang E, Chen Y, Pan X, Fang L, Zhu M, Fei W, Lu B, Gan Z*. Disuse-associated loss of the protease LONP1 in muscle impairs mitochondrial function and causes reduced skeletal muscle mass and strength. Nat Commun. 2022; 13(1):894. 

原文链接:https://www.nature.com/articles/s41467-022-28557-5

4. He S, Fu T, Yu Y, Liang Q, Li L, Liu J, Zhang X, Zhou Q, Guo Q, Xu D, Chen Y, Wang X, Chen Y, Liu J, Gan Z*and Liu Y*. IRE1α regulates skeletal muscle regeneration through Myostatin mRNA decay. J Clin Invest. 2021;131(17): e143737.

原文链接:https://www.jci.org/articles/view/143737

5. Xiao L#, Liu J#, Sun Z#, Yin Y, Mao Y, Xu D, Liu L, Xu Z, Guo Q, Ding C, Sun W, Yang L, Zhou Z, Zhou D, Fu T, Zhou W, Zhu Y, Chen XW, Li J, Chen S, Xie X, Gan Z*. AMPK-dependent and -independent coordination of mitochondrial function and muscle fiber type by FNIP1.PLoS Genet. 2021; 17(3): e1009488.

原文链接:https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009488

6. Liu L#, Ding C#, Fu T, Feng Z, Lee JE, Xiao L, Xu Z, Yin Y, Guo Q, Sun Z, Sun W, Mao Y, Yang L, Zhou Z, Zhou D, Xu L, Zhu Z, Qiu Y, Ge K, Gan Z*. Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction. J Clin Invest. 2020, 130(9):4710-4725. 

原文链接:https://www.jci.org/articles/view/136155

7. Liu L#, Cai J#, Wang H#, Liang X#, Zhou Q#, Ding C, Zhu Y, Fu T, Guo Q, Xu Z, Xiao L, Liu J, Yin Y, Fang L, XueB, Wang Y, Meng ZX, He A, Li JL, Liu Y, Chen XW*, Gan Z*. Coupling of COPII vesicle trafficking to nutrient availability by the IRE1a-XBP1s axis. Proc Natl Acad Sci USA. 2019; 116(24): 11776-11785.

原文链接:https://www.pnas.org/doi/full/10.1073/pnas.1814480116

8. Fu T, Xu Z, Lin L, Guo Q, Wu H, Liang X, Zhou D, Xiao L, Liu L, Liu Y, Zhu M, Chen Q*, Gan Z*. Mitophagy directs muscle-adipose crosstalk to alleviate dietary obesity. Cell Reports. 2018; 23: 1357–1372.

原文链接:https://linkinghub.elsevier.com/retrieve/pii/S2211-1247(18)30515-1

9. Gan Z*, Fu T, Kelly DP*, Vega RB*. Skeletal muscle mitochondrial remodeling in exercise and diseases. Cell Research. 2018; 28(10): 969-980.

原文链接:https://www.nature.com/articles/s41422-018-0078-7

10. Liu J, Liang X, Zhou D, Lai L, Xiao L, Liu L, Fu T, Kong Y, Zhou Q, Vega R, Zhu MS, Kelly DP, Gao X, Gan Z*. Coupling of mitochondrial function and skeletal muscle fiber type by a miR-499/Fnip1/AMPK circuit. EMBO Mol Med. 2016; 8(10):1212-1228.

原文链接:https://www.embopress.org/doi/full/10.15252/emmm.201606372


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