教授,医药生物技术国家重点实验室
地址:南京市浦口区学府路12号,210061
邮箱:gaoxiang@nju.edu.cn
研究领域 |
疾病动物模型及机理研究
工作经历 |
2002-至今,主任,国家遗传工程小鼠资源库
2002-2012,所长,南京大学模式动物研究所
2000-2001,教授, 南京大学分子医学研究所
1998-2000,Research associate, 神经科学中心, University of North Carolina at Chapel Hill
荣誉奖励 |
2002,教育部长江奖励计划特聘教授
2010,江苏省科技进步二等奖
2009,基金委杰出青年科学基金
2011,教育部科技进步一等奖
2015,高等学校科学研究优秀成果奖(科技进步)特等奖
2016,度国家科学技术进步奖二等奖
学术任职 |
国际小鼠表型分析联盟指导委员会委员
中国细胞生物学学会监事长
国家实验动物专家委员会委员
代表性成果 |
1. Chen, Q., J. Zheng, D. Wang, Q. Liu, L. Kang, X. Gao*, and Z. Lin*, Nitrosonisoldipine is a selective inhibitor of inflammatory caspases and protects against pyroptosis and related septic shock. Eur J Immunol, 2021. 51(5): p. 1234-1245.
2. Zou, D., J. Pei, J. Lan, H. Sang, H. Chen, H. Yuan, D. Wu, Y. Zhang, Y. Wang, D. Wang, Y. Zou, D. Chen, J. Ren*, X. Gao*, and Z. Lin*, A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption. EBioMedicine, 2020. 52: p. 102652.
3. Wang, D., J. Zheng, Q. Hu, C. Zhao, Q. Chen, P. Shi, Q. Chen, Y. Zou, D. Zou, Q. Liu, J. Pei, X. Wu, X. Gao*, J. Ren*, and Z. Lin*, Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis. Cell Death Differ, 2020. 27(2): p. 466-481.
4. Sun, M., S. Zheng, X. Gao*, and Z. Lin*, The role of immune cells in obesogenic memory. Cell Mol Immunol, 2020. 17(8): p. 884-886.
5. Zheng JS, Wang DY, Chen QY, Liu QY, Lin ZY, Hu QY, Wu XW, Gao X*, Li QR*, Ren JA* (2020) Hypertonic saccharide solution delays pyroptosis in macrophage regardless of the membrane binding of gasdermin D N-terminal. Eur J Immunol. 50:464-7
6. Zheng M, Li D, Zhao Z, Shytikov D, Xu Q, Jin X, Liang J, Lou J, Wu S, Wang L, Hu H, Zhou Y, Gao X*, Lu L* (2019) Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection. PNAS USA, 116:11422-7
7. Wang, Y., P. Shi, Q. Chen, Z. Huang, D. Zou, J. Zhang, X. Gao*, and Z. Lin*, Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation. J Mol Cell Biol, 2019. 11(12): p. 1069-1082.
8. Xu Q, Jin XX, Zheng MZ, Rohila D, Fu GT, Wen ZY, Lou J, Wu S, Sloan R, Wang L, Hu H, Gao X*, Lu LR* (2019) Phosphatase PP2A is essential for TH17 differentiation. PNAS USA. 116: 982-987
9. Chen, Q., P. Shi, Y. Wang, D. Zou, X. Wu, D. Wang, Q. Hu, Y. Zou, Z. Huang, J. Ren, Z. Lin*, and X. Gao*, GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity. J Mol Cell Biol, 2019. 11(6): p. 496-508.
10. Chen, Q., P. Shi, D. Wang, Q. Liu, X. Li, Y. Wang, D. Zou, Z. Huang, X. Gao*, and Z. Lin*, Epidermis-Activated Gasdermin-A3 Enhances Thermogenesis of Brown Adipose Tissue through IL-6/Stat3 Signaling. Am J Pathol, 2019. 189(5): p. 1041-1052.
11. Zou, J., B. Lai, M. Zheng, Q. Chen, S. Jiang, A. Song, Z. Huang, P. Shi, X. Tu, D. Wang, L. Lu, Z. Lin*, and X. Gao*, CD4+ T cells memorize obesity and promote weight regain. Cell Mol Immunol, 2018. 15(6): p. 630-639.
12. Wang QH, Tang J, Huang Z, Song AY, Hou SY, Gao X*, Ruan HB* (2018) Inhibition of PPARγ, adipogenesis and insulin sensitivity by MAGED1. J Endocrinol. 239:167-180
13. Lin, Z., F. Liu, P. Shi, A. Song, Z. Huang, D. Zou, Q. Chen, J. Li, and X. Gao*, Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C. Stem Cell Res Ther, 2018. 9(1): p. 47.
14. Lai BB, Zou JH, Lin ZY, Qu ZP, Song AY, Xu Y*, Gao X* (2018) Haploinsufficiency of hnRNP U changes activity pattern and metabolic rhythms. Am J Path, 188(1):173-183.
团队风采 |