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  • 高翔

教授,医药生物技术国家重点实验室 

地址:南京市浦口区学府路12号,210061

邮箱:gaoxiang@nju.edu.cn









研究领域


疾病动物模型及机理研究



工作经历


2002-至今,主任,国家遗传工程小鼠资源库

2002-2012,所长,南京大学模式动物研究所

2000-2001,教授南京大学分子医学研究所

1998-2000Research associate, 神经科学中心, University of North Carolina at Chapel Hill



荣誉奖励


2002,教育部长江奖励计划特聘教授

2010,江苏省科技进步二等奖

2009,基金委杰出青年科学基金

2011,教育部科技进步一等奖

2015,高等学校科学研究优秀成果奖(科技进步)特等奖

2016,度国家科学技术进步奖二等奖



学术任职


国际小鼠表型分析联盟指导委员会委员

中国细胞生物学学会监事长

国家实验动物专家委员会委员




代表性成果

1. Chen, Q., J. Zheng, D. Wang, Q. Liu, L. Kang, X. Gao*, and Z. Lin*, Nitrosonisoldipine is a selective inhibitor of inflammatory caspases and protects against pyroptosis and related septic shock. Eur J Immunol, 2021. 51(5): p. 1234-1245. 

2. Zou, D., J. Pei, J. Lan, H. Sang, H. Chen, H. Yuan, D. Wu, Y. Zhang, Y. Wang, D. Wang, Y. Zou, D. Chen, J. Ren*, X. Gao*, and Z. Lin*, A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption. EBioMedicine, 2020. 52: p. 102652.

3. Wang, D., J. Zheng, Q. Hu, C. Zhao, Q. Chen, P. Shi, Q. Chen, Y. Zou, D. Zou, Q. Liu, J. Pei, X. Wu, X. Gao*, J. Ren*, and Z. Lin*, Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis. Cell Death Differ, 2020. 27(2): p. 466-481.

4. Sun, M., S. Zheng, X. Gao*, and Z. Lin*, The role of immune cells in obesogenic memory. Cell Mol Immunol, 2020. 17(8): p. 884-886.

5. Zheng JS, Wang DY, Chen QY, Liu QY, Lin ZY, Hu QY, Wu XW, Gao X*, Li QR*, Ren JA* (2020) Hypertonic saccharide solution delays pyroptosis in macrophage regardless of the membrane binding of gasdermin D N-terminal. Eur J Immunol. 50:464-7

6. Zheng M, Li D, Zhao Z, Shytikov D, Xu Q, Jin X, Liang J, Lou J, Wu S, Wang L, Hu H, Zhou Y, Gao X*, Lu L* (2019) Protein phosphatase 2A has an essential role in promoting thymocyte survival during selection. PNAS USA, 116:11422-7

7. Wang, Y., P. Shi, Q. Chen, Z. Huang, D. Zou, J. Zhang, X. Gao*, and Z. Lin*, Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation. J Mol Cell Biol, 2019. 11(12): p. 1069-1082.

8. Xu Q, Jin XX, Zheng MZ, Rohila D, Fu GT, Wen ZY, Lou J, Wu S, Sloan R, Wang L, Hu H, Gao X*, Lu LR* (2019) Phosphatase PP2A is essential for TH17 differentiation. PNAS USA. 116: 982-987

9. Chen, Q., P. Shi, Y. Wang, D. Zou, X. Wu, D. Wang, Q. Hu, Y. Zou, Z. Huang, J. Ren, Z. Lin*, and X. Gao*, GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity. J Mol Cell Biol, 2019. 11(6): p. 496-508.

10. Chen, Q., P. Shi, D. Wang, Q. Liu, X. Li, Y. Wang, D. Zou, Z. Huang, X. Gao*, and Z. Lin*, Epidermis-Activated Gasdermin-A3 Enhances Thermogenesis of Brown Adipose Tissue through IL-6/Stat3 Signaling. Am J Pathol, 2019. 189(5): p. 1041-1052.

11. Zou, J., B. Lai, M. Zheng, Q. Chen, S. Jiang, A. Song, Z. Huang, P. Shi, X. Tu, D. Wang, L. Lu, Z. Lin*, and X. Gao*, CD4+ T cells memorize obesity and promote weight regain. Cell Mol Immunol, 2018. 15(6): p. 630-639.

12. Wang QH, Tang J, Huang Z, Song AY, Hou SY, Gao X*, Ruan HB* (2018) Inhibition of PPARγ, adipogenesis and insulin sensitivity by MAGED1. J Endocrinol. 239:167-180

13. Lin, Z., F. Liu, P. Shi, A. Song, Z. Huang, D. Zou, Q. Chen, J. Li, and X. Gao*, Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C. Stem Cell Res Ther, 2018. 9(1): p. 47.

14. Lai BB, Zou JH, Lin ZY, Qu ZP, Song AY, Xu Y*, Gao X* (2018) Haploinsufficiency of hnRNP U changes activity pattern and metabolic rhythms. Am J Path, 188(1):173-183.


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