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  • 侯亚义

教授、博士生导师,医药生物技术国家重点实验室 

地址:南京市栖霞区仙林大道163号,210023

邮箱:yiyihou@nju.edu.cn









研究领域


固有免疫与炎症性疾病



工作经历


1991-1993,日本爱媛大学,生物化学专业,访问学者

1998-1998,日本东京大学,生命科学研究院,特别研究员

2001-2003,美国密西根大学,医学院,访问学者

1998- ,南京大学,教授,博士生导师



荣誉奖励


2005,国家科学技术科技进步二等奖

2007,江苏省科技进步奖三等奖

2014,江苏省科技进步奖一等奖

2016,江苏省高校科学技术研究奖二等奖

2017,江苏省科技进步奖一等奖



学术任职


曾任江苏省免疫学会常务理事




代表性成果

[1] D. Li, L. Lu, W. Kong, X.Y Xia, Y.C. Pan, J.M. Li, J.L. Wang, T.T. Wang*, J. Liang*, H. Dou*, Y. Hou*.C-type lectin receptor Dectin3 deficiency balances the accumulation and function of FoxO1-mediated LOX-1 + M-MDSCs in relieving lupus-like symptoms. Cell Death Dis. 2021 Sep 3;12(9):829.

原文链接:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8417277/

[2]  L. Lu, H.N. Wang, X. Liu, L. P.Tan, X.Y. Qiao, J.L. Ni, Y. Sun*, J. Liang*, Y.Y. Hou*, H. Dou*.Pyruvate kinase isoform M2 impairs cognition in systemic lupus erythematosus by promoting microglial synaptic pruning via the β-catenin signaling pathway. J Neuroinflammation. 2021 Oct 1.3;18(1):229. 

原文链接:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8513209/

[3] Y. Li, Y.J. Xu, X.H. Liu, X. Yan, Y. Lin, Q. Tan*, Y.Y. Hou*. mTOR inhibitor INK128 promotes wound healing by regulating MDSCs. Stem Cell Res Ther. 2021 Mar 10;12(1):170. 

原文链接:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7944919/

[4] Y.J. Xu, X.H. Liu, Y. Li, H. Dou, H.P. Liang*, Y.Y. Hou*. SPION-MSCs enhance therapeutic efficacy in sepsis by regulating MSC-expressed TRAF1-dependent macrophage polarization. Stem Cell Res Ther. 2021 Oct 9;12(1):531.

原文链接:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8501658/

[5] X.H. Liu, Y.J. Xu, L.J. Yin, Y.Y. Hou*, S.L. Zhao*. Chitosan-Poly(Acrylic Acid) Nanoparticles Loaded with R848 and MnCl 2 Inhibit Melanoma via Regulating Macrophage Polarization and Dendritic Cell Maturation. Int J Nanomedicine. 2021 Aug 21;16:5675-5692.

原文链接:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387326/

[6] X.Y. Qiao, H.L. Wang, L. Lu, J.L. Chen, Q.P. Cheng, M. G, Y.Y. Hou*, H. Dou*. Hippocampal microglia CD40 mediates NPSLE cognitive dysfunction in mice. J Neuroimmunol. 2021 Aug 15;357:577620.

原文链接:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8387326/

[7] X.H. Liu, Y.J. Xu, Y. Li, Y.C. Pan, S.L. Zhao*, Y.Y. Hou*. Ferumoxytol-β-glucan Inhibits Melanoma Growth via Interacting with Dectin-1 to Polarize Macrophages into M1 Phenotype. Int J Med Sci. 2021 Jun 26;18(14):3125-3139. 

原文链接:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8364471/

[8] J.H. Fu, L. Lu, H.N. Wang, Y.Y. Hou*, H. Dou*. Hirsutella sinensis mycelium regulates autophagy of alveolar macrophages via TLR4/NF-κB signaling pathway. Int J Med Sci. 2021 Feb 18;18(8):1810-1823.

原文链接:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7976595/

[9] G.P. Shi, D. Li, D.Y. Zhang, Y.J. Xu, Y.C. Pan, L. Lu, J.M. Li, X.Y. Xia, H. Dou*, Y.Y. Hou*. IRF-8/miR-451a regulates M-MDSC differentiation via the AMPK/mTOR signal pathway during lupus development. Cell Death Discov. 2021 Jul 16;7(1):179.

原文链接:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8289825/

[10] L. Lu, H.Y Zhu, H.L. Wang, H.P Liang*, Y.Y. Hou*, H. Dou*. H. sinensis mycelium inhibits epithelial-mesenchymal transition by inactivating the midkine pathway in pulmonary fibrosis. Front Med. 2021 Apr;15(2):313-329.

原文链接:https://link.springer.com/article/10.1007/s11684-020-0737-1


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