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  • 胡一桥

教授,南京大学医学院

地址:南京市汉口路22号,210093   

邮箱:huyiqiao@nju.edu.cn









研究领域


肿瘤靶向给药技术及肿瘤耐药性逆转

纳米给药技术和缓控释制剂技术



工作经历


2015.01-至今,教授,南京大学医学院

2001-2014.12,教授,南京大学生命科学学院

1989-2001,教师,中国药科大学药学院

1982-1989,研究员,江苏省医药工业研究所



荣誉奖励


2000年,教育部科技成果完成证书

2000年,江苏省教学成果一等奖

2000年,教育部教学成果二等奖

2006年,教育部自然科学一等奖



代表性成果

1. A. Yuan, X. Qiu, X. Tang, W. Liu, J. Wu, Y. Hu*, Self-assembled PEG-IR-780-C13 micelle as a targeting, safe and highly-effective photothermal agent for in vivo imaging and cancer therapy, Biomaterials, 51 (2015) 184-193.

2. X. Qiu, Y. Zhang, X. Zhao, S. Zhang, J. Wu, H. Guo, Y. Hu*, Enhancement of endothelial differentiation of a
dipose derived mesenchymal stem cells by a three-dimensional culture system of microwell, Biomaterials, 53 (2015) 600-608.

3. A. Yuan, X. Tang, X. Qiu, K. Jiang, J. Wu, Y. Hu*, Activatable photodynamic destruction of cancer cells by NIR dye/photosensitizer loaded liposomes, Chemical Communications, 51 (2015) 3340-3342.

4. A. Yuan, B. Laing, Y. Hu*, X. Ming, Direct oligonucleotide-photosensitizer conjugates for photochemical delivery of antisense oligonucleotides, Chemical Communications, 51 (2015) 6678-6680.

5.C. Jiang, H. Cheng, A. Yuan, X. Tang, J. Wu, Y. Hu*, Hydrophobic IR780 encapsulated in biodegradable human
 serum albumin nanoparticles for photothermal and photodynamic therapy, Acta Biomaterialia, 14 (2015) 61-69.

6. T. Lin, Y. Hu*, et al. A Floating Hydrogel System Capable of Generating CO Bubbles to Diminish Urinary Obstruction After Intravesical Instillation, Pharm Res, (2014).

7. L. Zhao, Y. Hu*, et al. Rational design of drug-eluting stents via electrospray and in vivo evaluation of preventing oesophageal stricture, Rsc Advances, 4 (2014) 16885-16892.

8.Z. Meng, X. Yang, D. Hu, K. Wang, F. Zhi, X. Chen, G. Gong, J. Wu, Y. Hu*, Replacing Heme with Paclitaxel to 
Prepare Drug-Loaded Globin Nanoassembles for CD163 Targeting, Journal of Pharmaceutical Sciences, 104 (2015) 1045-1055.
9. T. Lin, Y. Hu*, et al. In situ floating hydrogel for intravesical delivery of adriamycin without blocking urinary tract, J Pharm Sci, 103 (2014) 927-936.

10.Z. Meng, L. Meng, K. Wang, J. Li, X. Cao, J. Wu, Y. Hu*, Enhanced hepatic targeting, biodistribution and antifi  brotic efficacy of tanshinone IIA loaded globin nanoparticles, European journal of pharmaceutical sciences : official 
journal of the European Federation for Pharmaceutical Sciences, 73 (2015) 35-43.

11. D. Ding, Y. Hu*, et al. Novel Self-assembly Endows Human Serum Albumin Nanoparticles with an Enhanced Antitumor Efficacy, AAPS PharmSciTech, 15 (2014) 213-222.
近年申请及授权专利

1. 蛋白質及びペプチドナノ粒子のアンフォールディング利用した薬剤送達方法, 特许第5570599号.(已授权)2014.7.4授权  分类号A61K

2. Methods for drug delivery comprising unfolding and folding proteins and peptide nanoparticles, US12851600.

3. Methods for drug delivery comprising unfolding and folding proteins and peptide nanoparticles, EP10808554.

4. Preparation method of protein or peptide nanoparticles for in vivo drug delivery by unfolding and refolding, WO/2011/017835, PCT/CN2009/073180.

5. Methods for drug delivery comprising unfolding and folding proteins and peptide nanoparticles, WO/2011/019585, PCT/US2010/044642.

6. A conjugate of biomacromolecule with bioreductive and preparative method thereof, WO/2006/102854, PCT/CN2006/000582.

7.  一种用于制备体内递送药理活性物质的蛋白纳米粒的方法,ZL201010247885.7.(已授权)

8.  一种生物大分子与生物还原剂的结合物及其制备方法,ZL200680018075.6.(已授权)

9.  氟西汀缓释片,ZL02112232.6.(已授权)

10. 盐酸非洛普的缓释制剂及其制备方法,ZL200410041200.8.(已授权)

11. 利巴韦林眼凝胶眼药及其生产工艺,ZL200410079052.9.(已授权)

12. 具有P-糖蛋白抑制和多药耐受逆转功能的化合物及其盐,ZL200610039339.8.(已授权)

13. 重组人血管内皮抑制素长效制剂及其制备方法和用途,ZL200710021667.X.(已授权)

14. 一种血红蛋白纳米粒及其制备方法,201410099459.1.

15. 一种用于制备体内递送药理活性物质的蛋白纳米粒的方法,201310101755.6.

16. 一种用于制备体内递送药理活性物质的蛋白纳米粒的方法,201310101785.7.

17. 一种姜黄素口服纳米粒及其制备方法,201310399929.1.

18. 一种姜黄素鼻用凝胶剂及其制备方法和应用,201110394215.2.

19. 含有二氢吡啶钙通道阻断剂的组合物及其制备方法,200810020088.8.

20. 一种转铁蛋白与生物还原剂的结合物及其制备方法,200510038631.3.

21. 用于消化道疾病的凹凸棒石固体及液体制剂,200510094361.8.

22. 红外光敏剂在光动力学治疗中的应用,200410014858.X.

23. 生脉粉针和生脉咀嚼片及其生产工艺,200410075375.0.

24. 生脉粉针和生脉咀嚼片及其生产工艺,03158220.6.

25. 凹凸棒石口服制剂,03131795.2.

26. 利巴韦林眼凝胶眼药及其生产工艺,03158297.4.


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