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  • 籍晓云

教授,博士生导师,医药生物技术国家重点实验室 

地址:南京市栖霞区仙林大道163号,210023

邮箱:xiaoyun.ji@nju.edu.cn









研究领域


病毒感染机理及其引起的宿主细胞先天性免疫应答机制



工作经历


2010-2011  牛津大学 结构生物学中心 博士后

2011-2016  耶鲁大学 分子生物物理与生物化学系 博士后、助理研究员

2016.06-至今 南京大学 生命科学学院 教授



荣誉奖励


2016国家第12批海外高层次人才计划入选者

2017江苏省“双创人才”计划入选者

2019江苏省“双创团队”计划入选者

2022江苏省第六期“333工程”第二层次人才入选者



学术任职


2017-2019,江苏省生物技术协会  青年专家工作组副主任

2022-2027,江苏省生物物理学会  秘书长




代表性成果

[1]Abula A* , Yang T* , Zhang Y, Li T,Ji X#. Enhancement of Escherichia coli Ribonuclease R Cytosine-Sensitive Activity by Single Amino Acid Substitution. Molecular Biotechnology2022.https://doi.org/10.1007/s12033-022-00533-w

[2]Guo H*, Gao Y*, Li T*, Li T*, Lu Y*, Zheng L, Liu Y, ...Huang A#,Jin A#,Yang H#,Rao Z#,Ji X#. Structures of Omicron Spike complexes and implications for neutralizing antibody development. Cell Reports. 2022;39, 110770.

[3]Li T, Wen Y, Guo H, Yang T, Yang H#, Ji X#. Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1Nup98 Complex to Compete With mRNA Nuclear Export. Frontiers in Molecular Biosciences2022;8(1345). (#co-correspondence)

[4]Wang M*, Li T*, Ouyang Z*, Tang K, Zhu Y, Song C, Sun H, Yu B#, Ji X#, Sun Y#. SHP2 allosteric inhibitor TK-453 alleviates psoriasis-like skin inflammation in mice via inhibition of IL-23/Th17 axis. iScience2022;25(4):104009. (#co-correspondence)

[5]Lin M*, Cui W*, Tian H*, Zhang Y, Chen C, Yang X, Chi H, Mu Z, Chen C, Wang Z, Ji X#, Yang H#, Lin Z#. Structural Basis of Zika Virus Helicase in RNA Unwinding and ATP Hydrolysis. ACS Infectious Diseases. 2022;8(1):150-8. (#co-correspondence)

[6]Abula A, Li X, Quan X, Yang T, Liu Y, Guo H, Li T, Ji X#. Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation. Nucleic Acids Research. 2021;49(8):4738-49. 

[7]F, Zhang Y, Hu J, Wang W, Li S, Hao Y, Shen M, Huang J, Long Y, Song S, Wu R, Mu S, Chen Q, Gao F, Wang J, Long S, Li L, Wu Y, Gao Y, Xu W, Cai X, Qu D, Zhang Z, Zhang H, Li N, Gao Q, Zhang G, He C, Wang W, Ji X, Tang N, Yuan Z, Xie Y#, Yang H#, Zhang B#, Huang A#, Jin A#. Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants. Nature Communications2021;12(1):6304. 

[8]Cui W, Braun E, Wang W, Tang J, Zheng Y, Slater B, Li N, Chen C, Liu Q, Wang B, Li X, Duan Y, Xiao Y, Ti R, Hotter D, Ji X, Zhang L, Cui J, Xiong Y, Sauter D#, Wang Z#, Kirchhoff F#, Yang H#. Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins. Proceedings of the National Academy of Sciences.2021;118(15):e2022269118. 

[9] Deng G, Chen W, Wang P, Zhan T, Zheng W, Gu Z, Wang X#, Ji X#, Sun Y#. Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice. International Immunopharmacology2019;74:105682.

[10]Buzovetsky O*, Tang C*, Knecht K, Antonucci J, Wu L, Ji X#, Xiong Y# . The SAM domain of mouse SAMHD1 is critical for its activation and regulation. Nature Communications2018;9(1):411(#co-correspondence)


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