教授、博导,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:xiaohongjiang@nju.edu.cn
研究领域 |
1)肥胖与2型糖尿病的分子机制及靶向治疗
2)心血管疾病的分子机制与运动干预治疗
3)小核酸药物体内靶向递送系统
工作经历 |
2011 -2014, 南京大学生命科学学院,专职助理研究员
2014 -2020, 南京大学生命科学学院,副教授,硕士生导师
2021 -至今, 南京大学生命科学学院, 教授,博士生导师
荣誉奖励 |
2012,获得教育部高等学校科学研究优秀成果奖自然科学一等奖
学术任职 |
江苏省生理科学会青年工作委员
代表性成果 |
1) Wu X#, Cui L#, Wang H#, Xu J#, Zhong Z, Jia X, Wang J, Zhang H, Shi Y, Tang Y, Yang Q, Liang Q, Zhang Y*, Li J*, Jiang X*. Impact of dietary sucralose and sucrose-sweetened water intake on lipid and glucose metabolism in male mice. Eur J Nutr. 2022 Aug 7. doi: 10.1007/s00394-022-02980-2.
2) Wei Z#, Chong H#, Jiang Q#, Tang Y, Xu J, Wang H, Shi Y, Cui L, Li J, Zhang Y, Xue Y, Li J, Liu G, Chen X, Wang D*, Zhang CY*, Jiang X*. Smooth muscle overexpression of PGC1α attenuates atherosclerosis in rabbits. Circ Res. 2021 Jun 24. doi:10.1161/CIRCRESAHA.120.317705.
3) Li J#, Zhang Y#, Ye Y#, Li D#, Liu Y, Lee E, Zhang M, Dai X, Zhang X, Wang S, Zhang J, Jia W, Zen K, Vidal-Puig A*, Jiang X*, Zhang CY*. Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR-29 family. J Extracell Vesicles. 2021 Jan; 10(3):e12055. doi: 10.1002/jev2.12055.
4) Ye Y#, Zhang X#, Xie F, Xu B, Xie P, Yang T, Shi Q, Zhang CY, Zhang Y, Chen J*, Jiang X*, Li J*. An engineered exosome for delivering sg RNA:Cas9 ribonucleoprotein complex and genome editing in recipient cells. Biomaterials Science. 2020 May 19; 8(10):2966-2976. doi: 10.1039/d0bm00427h.
5) Chong H#, Wei Z#, Namuhan#, Sun G, Zheng S, Zhu X, Xue Y, Zhou Q, Guo S, Xu J, Wang H, Cui L, Zhang CY*, Jiang X*, Wang D*.The PGC-1α/NRF1/miR-378a axis protects vascular smooth muscle cells from FFA-induced proliferation, migration and inflammation in atherosclerosis. Atherosclerosis. 2020 Mar; 297:136-145. doi:10.1016/j.atherosclerosis. 2020.02.001
6) Zheng S*, Guo S*, Sun G*, Shi Y, Wei Z, Tang Y, He F, Shi C, Dai P, Chong H, Samuelson I, Zen K, Zhang CY, Zhang Y#, Li J#, Jiang X#. Gain of metabolic benefit with ablation of miR-149-3p from subcutaneous adipose tissue in diet-induced obese mice. Mol Ther Nucleic Acids. 2019 Dec 6; 18:194-203. doi: 10.1016/j.omtn.2019.07.024.
7) Hou D*, He F*, Ma L*, Cao M*, Zhou Z, Wei Z, Xue Y, Sang X, Chong H, Tian C, Zheng S, Li J, Zen K, Chen X, Hong Z#, Zhang CY#, Jiang X#. The potential atheroprotective role of plant MIR156a as a repressor of monocyte recruitment on inflamed human endothelial cells. J Nutr Biochem. 2018 Jul; 57: 197-205. doi: 10.1016/j.jnutbio.2018.03.026.
8) Liu Y, Chen X, Cheng R, Yang F, Yu M, Wang C, Cui S, Hong Y, Liang H, Liu M, Zhao C, Ding M, Sun W, Liu Z, Sun F, Zhang C, Zhou Z#, Jiang, X#, Chen X#. The Jun/miR-22/HuR regulatory axis contributes to tumorigenesis in colorectal cancer. Mol Cancer. 2018 Jan 19; 17(1):11. doi:10.1186/s12943-017-0751-3.
9) Ding H*, Zheng S*, Garcia-Ruiz D, Hou D, Wei Z, Liao Z, Li L, Zhang Y, Han X, Zen K, Zhang CY#, Li J#, Jiang X#. Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16. Nature Commun. 2016 May 31; 7:11533. doi: 10.1038/ncomms11533
10) Xue Y*, Wei Z*, Ding H*, Wang Q, Zhou Z, Zheng S, Zhang Y, Hou D, Liu Y, Zen K, Zhang CY, Li J#, Wang D#, Jiang X#. MicroRNA-19b/221/222 induces endothelial cell dysfunction via suppression of PGC-1α in the progression of atherosclerosis. Atherosclerosis. 2015 Aug; 241(2):671-81. doi: 10.1016/j.atherosclerosis.2015.06.031.
团队风采 |