教授、模式所教工党支部书记,医药生物技术国家重点实验室
地址:南京市浦口区学府路12号,210061
邮箱:yanli@nju.edu.cn
研究领域 |
人源化小鼠模型、免疫治疗
工作经历 |
2012.7-2015.6 博士后,法国国家健康与医学研究院668号实验室
2015.7-2016.5 合同制研究员,巴斯德研究所
2016.6-2018.6 助理研究员,巴斯德研究所
2018-,南京大学教授
2019-,南京大学博士生导师
荣誉奖励 |
2019,国家重点研发计划青年首席
2019,江苏省特聘教授
2020,江苏省双创团队领军人才
2021,国家自然科学基金委优秀青年
学术任职 |
2022,第六届国际人源化小鼠大会(IWHM6)国际学术委员会成员
2020-2021,Frontiers in Immunology/Microbiology人源化小鼠专刊副主编
2019-,中国细胞生物学学会-免疫分会委员
2021-,中国医药生物技术协会-疾病模型分会委员
2019-,中国抗癌协会-免疫代谢分会委员
2019-,江苏省发育细胞生物学学会理事
代表性成果 |
1. Deshan Ren, Wei Liu, Shuai Ding, Yan Li*(2022) The creation of human immune system mice and hydrodynamic injection to modulate human hematopoiesis in vivo, STAR protocols
2. Xiufei Chen, Wenjie Zhou, Ren-Hua Song, Shuang Liu, Shu Wang, Yujia Chen, Chao Gao, Chenxi He, Jianxiong Xiao, Lei Zhang, Tianxiang Wang, Peng Liu, Kunlong Duan, Chen Zhang, Jinye Zhang, Yiping Sun, Felix Jackson, Fei Lan, Yun Liu, Yanhui Xu, Justin Jong-Leong Wong, Pu Wang, Hui Yang, Yue Xiong, Tong Chen*, Yan Li*, Dan Ye*.(2022) Tumor suppressor CEBPA interacts with and inhibits DNMT3A activity, Science Advances
3. Tao Cheng#, Shuai Ding#, Shanshan Liu, Yan Li*, Lingyun Sun* (2021).Human umbilical cord-derived mesenchymal stem cell therapy ameliorate lupus through increasing CD4+ T cell senescence via MiR-199a-5p/Sirt1/p53 axis. Theranostics, doi: 10.7150/thno.48080.
4. Wei Liu; Hua Song; Xiaojing Li; Deshan Ren; Shuai Ding; Yan Li* (2021). Lipid Metabolism in Tumor Associated Myeloid-Derived Suppressor Cells, Lipid Metabolism in Tumor Immunity, Springer Book
5. Yan Li*, Guillemette Masse Ranson, Zacarias Garcia, Timothee Bruel, Ayrin Kok-Harunova, Helene Strick-Marchand, Gregory Jouvion, Nicolas Serafini, Ai Ing Lim, Mathilde Dusseaux, Thierry Hieu, Frank Bourgade, Antoine Toubert, Daniela Finke, Oliver Schwartz, Phillippe Bousso, Hugo Mouquet and James P. Di Santo. (2018) A human immune system mouse model with robust lymph node development. Nature Methods 10.1038/s41592-018-0071-6.
6. Yan Li*, Helene Strick-Marchand, Ai Ing Lim, Jiazi Ren, Guillemette Masse-Ranson, Dan Li, Gregory Jouvion, Lars Rogge, Sophie Lucas, Bin Li and James P. Di Santo. (2017) Regulatory T cells control toxicity in a humanized model of IL-2 therapy. Nature Communications doi: 10.1038/s41467-017-01570-9.
7. Ai Ing Lim, Yan Li, Silvia Lopez-Lastra, Ralph Stadhouders, Franziska Paul, Armanda Cassrouge, Nicolas Serafini, Anne Puel, Laura Surace, Guillemette Masse-Ranson, Helene Strick-Marchand, Lionel Le Bourhis, Roberto Cocchi, Davide Topazio, Paolo Graziano, Lucia Anna Muscarella, Lars Rogge, Jean-Michel Sallenave, Matthieu Allez, Thomas Graf, Rudi W. Hendriks, Jean-Laurent Casanova, Ido Amit, Hans Yssel and James P. Di Santo. (2017) Systemic human ILC precursors provide a substrate for tissue ILC differentiation, Cell. DOI: 10.1016/j.cell.2017.02.021.
8. Yan Li*, Jean-Jacques Mention*, Nathalie Court, Antoine Toubert, Hergen Spits, Nicolas Legrand, Erwan Corcuff, Helene Strick-Marchand and James P. Di Santo. (2016) A novel Flt3-deficient HIS mouse model with selective enhancement of human DC development. European Journal of Immunology. DOI: 10.1002/eji.201546132.
9. Yan Li* and James P. DI Santo. (2015) Probing human NK cell biology using Human Immune System (HIS) mice. Current Topics in Microbiology and Immunology. 95:191-208. doi: 10.1007/82_2015_488.
10. Yan Li*, Silvia Lopez-Lastra, Guillemette X. Masse and James P. Di Santo. (2015) NK cell development in human immune system (HIS) mice and their role in HIV pathogenesis. Humanized Mice for HIV Research (Book Chapter), DOI 10.1007/978-1-4939-1655-9_14
团队风采 |