教授,医药生物技术国家重点实验室
地址:南京市浦口区12号,210061
邮箱:liujianghuai@nju.edu.cn
研究领域 |
免疫监控与肿瘤;基因改造与细胞工程
工作经历 |
2009-,南京大学教授
代表性成果 |
[1] Zhang G†, Liu Y†, Huang S†, Qu S, Cheng D, Yao Y, Ji Q, Wang X*, Huang X* and Liu J*. Enhancement of prime editing via xrRNA motif-joined pegRNA. Nat Commun 2022, 13(1):1856.
[2] Wang Y†, Zhang G†, Meng Q†, Huang S, Guo P, Leng Q, Liu G*, Huang X* and Liu J*. Precise tumor immune rewiring via synthetic CRISPRa circuits gated by concurrent gain/loss of transcription factors. Nat Commun 2022, 13(1):1454.
[3] Gup P†, Yang L†, Zhang M, Zhang Y, Tong Y, Cao Y and Liu J*. A monocyte-orchestrated IFN-I-to-IL-4 cytokine axis instigates pro-tumoral macrophages and thwarts poly(I:C) therapy. J Immunol 2021, 207:408-420.
[4] Tong Y†, Zhou L†, Yang L, Cao Y, Qin FX and Liu J*. Concomitant Type I IFN and M-CSF signaling reprograms monocyte differentiation to drive pro-tumoral arginase production. EBioMedicine 2019, 39:132-44.
[5] Jiang H†, Shi H†, Sun M, Wang Y, Meng Q, Guo P, Cao Y, Chen J, Gao X, Li E* and Liu J*. PFKFB3-driven macrophage glycolytic metabolism is a crucial component of innate antiviral defense. J Immunol 2016, 197(7):2080-90.
[6] Du Y†, Meng Q†, Zhang J, Sun M, Shen B, Jiang H, Kang Y, Gao J, Huang X* and Liu J*. Functional annotation of cis-regulatory elements in human cells by dCas9/sgRNA. Cell Res 2015, 25(7):877-80.
[7] Jiang H, Lu Y, Yuan L, and Liu J* Regulation of Interleukin-10 Receptor Ubiquitination and Stability by Beta-TrCP-Containing Ubiquitin E3 Ligase. PLoS ONE 2011, 6: e27464.
[8] Liu J†, HuangFu WC†, Kumar KG, Qian J, Casey JP, Hamanaka RB, Grigoriadou C, Aldabe R, Diehl JA, Fuchs SY. Virus-induced unfolded protein response attenuates antiviral defenses via phosphorylation-dependent degradation of the type I interferon receptor. Cell Host Microbe 2009, 5:72-83.
团队风采 |