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  • 秦进中

教授,医药生物技术国家重点实验室 

地址:南京市栖霞区仙林大道163号,210023

邮箱:qinjz@nju.edu.cn









研究领域


干细胞与再生医学


工作经历


2015-,南京大学博士生导师

2013-,南京大学教授


荣誉奖励


2015,江苏省双创人才


代表性成果

1. Zhu Y, Dong L, Wang C, Hao K, Wang J, Zhao L, Xu L, Xia Y, Jiang Q, Qin J.* Functional redundancy among Polycomb complexes in maintaining the pluripotent state of embryonic stem cells. Stem Cell Reports. 2022 May 10;17(5):1198-1214.

2. Wang C, Hao K, Dong L, Wang J, Zhao L, Xu L, Xia Y, Jiang Q, Qin J*.  The MuvB complex safeguards embryonic stem cell identity through regulation of the cell cycle machinery. J Biol Chem. 2022 Mar;298(3):101701.

3.Huang Y, Su T, Wang C, Dong L, Liu S, Zhu Y, Hao K, Xia Y*, Jiang Q*, Qin J*. Rbbp4 Suppresses Premature Differentiation of Embryonic Stem Cells. Stem Cell Reports. 2021 Mar 9;16(3):566-581.

4. Qin J*, Wang C, Zhu Y, Su T, Dong L, Huang Y, Hao K. Mga safeguards embryonic stem cells from acquiring extraembryonic endoderm fates. Science Advances. 2021 Jan 20;7(4):eabe5689.

5.Liu M, Zhu Y, Xing F, Liu S, Xia Y, Jiang Q, Qin J*. The polycomb group protein PCGF6 mediates germline gene silencing by recruiting histone-modifying proteins to target gene promoters. J Biol Chem. 2020 Jul 10;295(28):9712-9724.

6. Zhao W, Liu M, Ji H, Zhu Y, Wang C, Huang Y, Ma X, Xing G, Xia Y, Jiang Q, Qin J*. The polycomb group protein Yaf2 regulates the pluripotency of embryonic stem cells in a phosphorylation-dependent manner.  J Biol Chem. 2018 Aug 17;293(33):12793-12804.

7.Huang H, Xu C, Wang Y, Meng C, Liu W, Zhao Y, Huang XR, You W, Feng B, Zheng ZH, Huang Y, Lan HY, Qin J*, Xia Y*. Lethal (3) malignant brain tumor-like 2 (L3MBTL2) protein protects against kidney injury by inhibiting the DNA damage-p53-apoptosis pathway in renal tubular cells. Kidney Int. 2018 Apr;93(4):855-870.

8.Huang Y, Zhao W, Wang C, Zhu Y, Liu M, Tong H, Xia Y, Jiang Q, Qin J*. Combinatorial Control of Recruitment of a Variant PRC1.6 Complex in Embryonic Stem Cells. Cell Reports. 2018 Mar 13;22(11):3032-3043.

9. Zhao W, Huang Y, Zhang J, Liu M, Ji H, Wang C, Cao N, Li C, Xia Y, Jiang Q, Qin J*. Polycomb group RING finger proteins 3/5 activate transcription via an interaction with the pluripotency factor Tex10 in embryonic stem cells. J Biol Chem. 2017 Dec 29;292(52):21527-21537.

10.Zhao W, Tong H, Huang Y, Yan Y, Teng H, Xia Y, Jiang Q, Qin J*. Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity. J Biol Chem. 2017 Feb 17;292(7):2773-2784.

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