教授,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:yanchao@nju.edu.cn
研究领域 |
肿瘤药理学与神经药理学
工作经历 |
1999-2003 南京大学生物化学系 本科
2003-2005 南京大学生物化学系 硕士
2005-2011 美国科罗拉多大学药学院 博士(毒理学)
2011-2014 美国科罗拉多大学医学院 博士后
2015-2016 美国科罗拉多大学医学院 Research Instructor
2016- 南京大学生命科学学院 教授
2019- 南京大学人工智能生物医药技术研究院 执行院长
2019- 南京大学生理系 系主任
荣誉奖励 |
2003 国家奖学金二等奖
2011 美国科罗拉多大学最佳博士论文奖(每年只授予一人)
2011 国家优秀自费留学生奖学金
2011 美国毒理学会卡尔史密斯研究奖(全美第一名)
学术任职 |
2020- 中国神经生物学会神经肿瘤分会委员
代表性成果 |
[1] Chen ZP, Wang S, Zhao X, Fang W, Wang Z, Ye H, Wang MJ, Ke L, Huang T, Lv P, Jiang X, Zhang Q, Li L, Xie ST, Zhu JN, Hang C, Chen D*, Liu X*, Yan C*. Lipid-accumulated reactive astrocytes promote disease progression in epilepsy. Nat Neurosci. 2023; 26(4):542-554.
[2] Cheng R, Li F, Zhang M, Xia X, Wu J, Gao X, Zhou H, Zhang Z, Huang N, Yang X, Zhang Y, Shen S, Kang T, Liu Z, Xiao F, Yao H, Xu J*, Yan C*, Zhang N*. A novel protein RASON encoded by a lncRNA controls oncogenic RAS signaling in KRAS mutant cancers. Cell Res. 2023; 33(1):30-45.
[3] Hu H, Cheng R, Wang Y, Wang X, Wu J, Kong Y, Zhan S, Zhou Z, Zhu H, Yu R, Liang G, Wang Q, Zhu X, Zhang CY, Yin R*, Yan C*, Chen X*. Oncogenic KRAS signaling drives evasion of innate immune surveillance in lung adenocarcinoma by activating CD47. J Clin. Invest. 2023; 133(2):e153470.
[4] Wang Y, Zhang Y, Li P, Guo J, Huo F, Yang J, Jia R, Wang J, Huang Q, Theodorescu D*, Yu H*, Yan C*. Development of novel aptamer-based targeted chemotherapy for bladder cancer. Cancer Res. 2022;82(6):1128-1139.
[5] Jiang B, Zhao X, Chen W, Diao W, Ding M, Qin H, Li B, Cao W, Chen W, Fu Y, He K, Gao J, Chen M, Lin T, Deng Y, Yan C*, Guo H*. Lysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation. Nat Commun. 2022;13(1):4141.
[6] Zhang Y, Huo F, Cao Q, Jia R, Huang Q, Wang ZA, Theodorescu D, Lv Q*, Li P*, Yan C*. FimH confers mannose-targeting ability to Bacillus Calmette-Guerin for improved immunotherapy in bladder cancer. J Immunother Cancer.2022;10(3):e003939.
[7] Huang T, Xu T, Wang Y, Zhou Y, Yu D, Wang Z, He L, Chen Z, Zhang Y, Davidson D, Dai Y, Hang C*, Liu X*, Yan C*. Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4. Autophagy.2021;17(11):3592-3606.
[8] Fu Z, Zhang X, Zhou X, Ur-Rehman U, Yu M, Liang H, Guo H, Guo X, Kong Y, Su Y, Ye Y, Hu X, Cheng W, Wu J, Wang Y, Gu Y, Lu SF, Wu D, Zen K, Li J*, Yan C*, Zhang CY*, Chen X*. In vivo self-assembled small RNAs as a new generation of RNAi therapeutics. Cell Res. 2021;31(6):631-648.
[9] Yan C, Theodorescu D. RAL GTPases: Biology and potential as therapeutic targets in cancer. Pharmacological Reviews. 2018;70(1):1-11.
[10] Yan C, Liu D, Li L, Wempe MF, Guin S, Khanna M, Meier J, Hoffman B, Owens C, Wysoczynski CL, Nitz MD, Knabe EW, Brautigan DL, Paschal BM, Schwartz MA, Jones DN, Ross D, Meroueh SO, Theodorescu D. Discovery and characterization of small molecules that target the GTPase Ral. Nature. 2014;515(7527):443-447.
团队风采 |