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  • 殷武

教授,医药生物技术国家重点实验室 

地址:南京市仙林校区仙林大道163号,210023

邮箱:wyin@nju.edu.cn









研究领域


生化与分子药理学;中药药理学



工作经历


2012-,南京大学博士生导师

2011-,南京大学教授



荣誉奖励


2010,教育部新世纪人才计划入选者

2019,中药马钱子“减毒增效”制剂模式的创建,教育部(自然科学奖)二等奖

2021,有毒中药在治疗肿瘤与免疫相关疾病中的新作用机制与特色,世界中医药联合会-中医药国际贡献奖(科技进步)二等奖



学术任职


2021-,江苏省中药药理学-副主任委员




代表性成果

1.  Dan C, Jinjun B, Zi-Chun H, Lin M, Wei C, Xu Z, Ri Z, Shun C, Wen-Zhu S, Qing-Cai J, Wu Y*. Modulation of TNF-alpha mRNA stability by human antigen R and miR181s in sepsis-induced immunoparalysis. EMBO Mol Med 2015; 7:140-157

2.  Yin W, Cheng W, Shen W, Shu L, Zhao J, Zhang J, Hua ZC. Impairment of Na(+),K(+)-ATPase in CD95(APO-1)-induced human T-cell leukemia cell apoptosis mediated by glutathione depletion and generation of hydrogen peroxide. Leukemia 2007; 21:1669-1678

3. Yang K, Chen Y, Zhou J, Ma L, Shan Y, Cheng X, Wang Y, Zhang Z, Ji X, Chen L, Dai H, Zhu B, Li C, Tao Z, Hu X, Yin W*. Ursolic acid promotes apoptosis and mediates transcriptional suppression of CT45A2 gene expression in non-small-cell lung carcinoma harbouring EGFR T790M mutations. Br J Pharmacol 2019; 176:4609-4624 7.256

4. Feng S, Chen W, Cao D, Bian J, Gong FY, Cheng W, Cheng S, Xu Q, Hua ZC, Yin W*. Involvement of Na(+), K (+)-ATPase and its inhibitors in HuR-mediated cytokine mRNA stabilization in lung epithelial cells. Cell Mol Life Sci 2011; 68:109-124

5. Yao DD, Yang L, Wang Y, Liu C, Wei YJ, Jia XB, Yin W*, Shu L. Geniposide promotes beta-cell regeneration and survival through regulating beta-catenin/TCF7L2 pathway. Cell Death Dis 2015; 6:e1746 

6. Shi YL, Feng S, Chen W, Hua ZC, Bian JJ, Yin W*. Mitochondrial inhibitor sensitizes non-small-cell lung carcinoma cells to TRAIL-induced apoptosis by reactive oxygen species and Bcl-X(L)/p53-mediated amplification mechanisms. Cell Death Dis. 2014;5:e1579. 

7. Kai W, Yating S, Lin M, Kaiyong Y, Baojin H, Wu Y*, Fangzhou Y, Yan C. Natural product toosendanin reverses the resistance of human breast cancer cells to adriamycin as a novel PI3K inhibitor. Biochem Pharmacol 2018; 152:153-164 

8. Yin W, Li X, Feng S, Cheng W, Tang B, Shi YL, Hua ZC. Plasma membrane depolarization and Na,K-ATPase impairment induced by mitochondrial toxins augment leukemia cell apoptosis via a novel mitochondrial amplification mechanism. Biochem Pharmacol 2009; 78:191-202

9. Chen T, Yan D, Cheng X, Ji X, Bian J, Yin W*. miR-1224-5p Enhances Hepatic Lipogenesis by Targeting Adenosine Monophosphate-Activated Protein Kinase alpha1 in Male Mice. Endocrinology 2018; 159:2008-2021 

10. Wei C, Lin M, Jinjun B, Su F, Dan C, Yan C, Jie Y, Jin Z, Zi-Chun H, Wu Y*. Involvement of general control nonderepressible kinase 2 in cancer cell apoptosis by posttranslational mechanisms. Mol Biol Cell 2015; 26:1044-1057


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