教授,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:kzen@nju.edu.cn
研究领域 |
天然免疫
肿瘤免疫
非编码小RNA
工作经历 |
2006-,南京大学, 生命科学学院, 教授
2006-,南京大学博士生导师
1994-,南京大学教授
2015-2018,南京大学生命科学学院副院长
荣誉奖励 |
2012 谈家桢生命科学创新奖
2009,国家杰出青年人才计划
2007,长江学者奖励计划
学术任职 |
2010-,国家肾脏病临床中心特聘教授及全军肾脏病研究所副所长
代表性成果 |
1. Sun, X, Wang, D, Wang, Y, Ye, L, Shi, F, Qu, S, Liang, H, & Zen, K*. (2021). PKM2 controls the degranulation of secondary and tertiary granules in neutrophils by phosphorylating SNAP-23. Cellular & molecular immunology, 18(8), 2048–2050.
2. Ding, X, Wang, J, Huang, M, Chen, Z, Liu, J, Zhang, Q, Zhang, C, Xiang, Y, Zen, K*, & Li, L*. (2021). Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration. Nature communications, 12(1), 2030.
3. Qu, S, Jiao, Z, Lu, G, Yao, B, Wang, T, Rong, W, Xu, J, Fan, T, Sun, X, Yang, R, Wang, J, Yao, Y, Xu, G, Yan, X, Wang, T*, Liang, H*, & Zen, K*. (2021). PD-L1 lncRNA splice isoform promotes lung adenocarcinoma progression via enhancing c-Myc activity. Genome biology, 22(1), 104.
4. Liang HW, Jiao ZC, Rong WW, Qu S, Liao ZC, Sun XL,Wei Y, Zhao Q, Wang J, Liu Y, Chen X, Wang T, Zhang CY and Zen K*.3-Terminal 2-O-methylation of lung cancer miR-21-5p enhances its stability and association with Argonaute 2.Nucleic Acids Research, 2020, Vol. 48, No. 13,7027–7040.
5. Wang Y, Liang H, Jin F, Yan X, Xu G, Hu H, Liang G, Zhan S, Hu X, Zhao Q, Liu Y, Jiang ZY, Zhang CY, Chen X, Zen K*. (2019) Injured liver-released miRNA-122 elicits acute pulmonary inflammation via activating alveolar macrophage TLR7 signaling pathway. Proc Natl Acad Sci U S A. 26;116(13):6162-6171.
6. Zhu D, Pan C, Sheng J, Liang H, Bian Z, Liu Y, Trang P, Wu J, Liu F, Zhang CY, Zen K*. (2018) Human cytomegalovirus reprogrammes haematopoietic progenitor cells into immunosuppressive monocytes to achieve latency. Nat Microbiol. 2018 Apr;3(4):503-513.
7. Wang D, Sun X, Wei Y, Liang H, Yuan M, Jin F, Chen X, Liu Y, Zhang CY, Li L, Zen K*. (2018) Nuclear miR-122 directly regulates the biogenesis of cell survival oncomiR miR-21 at the posttranscriptional level. Nucleic Acids Res. 2018 Feb 28;46(4):2012-2029.
8. Wei Y, Wang D, Jin F, Bian Z, Li L, Liang H, Li M, Shi L, Pan C, Zhu D, Chen X, Hu G*, Liu Y, Zhang CY, Zen K*. (2017) Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23. Nat Commun. 8:14041.
9. Pan C, Zhu D, Wang Y, Li L, Li D, Liu F*, Zhang CY*, Zen K*. (2016) Human Cytomegalovirus miR-UL148D Facilitates Latent Viral Infection by Targeting Host Cell Immediate Early Response Gene 5. PLoS Pathog. 2016;12(11): e1006007.
10. Liang HW, Wang N, Wang Y, Wang F, Fu Z, Yan X, Zhu H, Diao W, Ding Y, Chen X, Zhang CY, Zen K. Hepatitis B virus-human chimeric transcript HBx-LINE1 promotes hepatic injury via sequestering cellular microRNA-122. J Hepatol. 2016 Feb;64(2):278-291.
团队风采 |