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  • 张青

教授、博导,医药生物技术国家重点实验室 

地址:南京市栖霞区仙林大道163号,210023

邮箱:zhangqing@nju.edu.cn









研究领域


Hedgehog信号转导调节研究

线粒体疾病机制研究

溶酶体疾病机制研究


工作经历


2009-至今,南京大学博士生导师

2009-至今,南京大学教授

2003-2009,博士后,UT Southwestern Medical Center at Dallas 


学术任职


美国遗传学会会员

中国细胞生物学学会会员



代表性成果

1.  Zhang QJiang J. (2021) Regulation of Hedgehog Signal Transduction by Ubiquitination and Deubiquitination. Int J Mol Sci. 22(24):13338.

2.  Jiang W, Yao X, Shan Z, Li W, Gao Y, Zhang Q. (2019) E3 ligase Herc4 regulates Hedgehog signalling through promoting Smoothened degradation. J Mol Cell Biol. 11(9):791-803.

3.  Zhou Z, Yao X, Pang S, Chen P, Jiang W, Shan Z, Zhang Q. (2018) The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened. J Mol Cell Biol. 10(3):243-257.

4.  Zhou Z, Yao X, Li S, Xiong Y, Dong X, Zhao Y, Jiang J, Zhang Q. (2015) Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling. Dev Cell. 34(1):58-72. 

5.  An J, Ren S, Murphy S, Dalangood S, Chang C, Pang X, Cui Y, Wang L, Pan Y, Zhang X, Zhu Y, Wang C, Halling G, Cheng L, Sukov W, Karnes R, Vasmatzis G, Zhang Q, Zhang J, Cheville J, Yan J, Sun Y, Huang H. (2015) Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation. Mol Cell. 59:1-13. 

6.  Liu C, Zhou Z, Chen P, Su MY, Chang CJ, Yan J, Jiang J, Zhang Q. (2014) Hedgehog signaling downregulates Suppressor of Fused through the HIB/SPOP-Crn axis in Drosophila. Cell Research. 24,595-609.

7.  Zhang Q, Shi Q, Chen Y, Yue T, Li S, Wang B, Jiang J. (2009) Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase. PNAS . 106(50):21191-6.

8.  Zhang LRen FZhang QChen YWang BJiang J. (2008) The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control. Dev Cell. 14, 377-387. 

9. Zhang Q,  Zhang LWang BOu CY,  Chien CTJiang J. (2006) A Hedgehog-induced BTB protein modulates Hedgehog signaling responses by degrading Ci/Gli transcription factor. Dev Cell. 10, 719-729.

10. Jia JZhang LZhang QTong CWang BHou FAmanai KJiang J. (2005) Phosphorylation of Cubitus interruptus by Double-time/CKIe and CKIa targets it   for Slimb/b-TRCP mediated proteolytic processing. Dev Cell. 9, 819-830.


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