教授、博导,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:zhangqing@nju.edu.cn
研究领域 |
Hedgehog信号转导调节研究
线粒体疾病机制研究
溶酶体疾病机制研究
工作经历 |
2009-至今,南京大学博士生导师
2009-至今,南京大学教授
2003-2009,博士后,UT Southwestern Medical Center at Dallas
学术任职 |
美国遗传学会会员
中国细胞生物学学会会员
代表性成果 |
1. Zhang Q,Jiang J. (2021) Regulation of Hedgehog Signal Transduction by Ubiquitination and Deubiquitination. Int J Mol Sci. 22(24):13338.
2. Jiang W, Yao X, Shan Z, Li W, Gao Y, Zhang Q. (2019) E3 ligase Herc4 regulates Hedgehog signalling through promoting Smoothened degradation. J Mol Cell Biol. 11(9):791-803.
3. Zhou Z, Yao X, Pang S, Chen P, Jiang W, Shan Z, Zhang Q. (2018) The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened. J Mol Cell Biol. 10(3):243-257.
4. Zhou Z, Yao X, Li S, Xiong Y, Dong X, Zhao Y, Jiang J, Zhang Q. (2015) Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling. Dev Cell. 34(1):58-72.
5. An J, Ren S, Murphy S, Dalangood S, Chang C, Pang X, Cui Y, Wang L, Pan Y, Zhang X, Zhu Y, Wang C, Halling G, Cheng L, Sukov W, Karnes R, Vasmatzis G, Zhang Q, Zhang J, Cheville J, Yan J, Sun Y, Huang H. (2015) Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation. Mol Cell. 59:1-13.
6. Liu C, Zhou Z, Chen P, Su MY, Chang CJ, Yan J, Jiang J, Zhang Q. (2014) Hedgehog signaling downregulates Suppressor of Fused through the HIB/SPOP-Crn axis in Drosophila. Cell Research. 24,595-609.
7. Zhang Q, Shi Q, Chen Y, Yue T, Li S, Wang B, Jiang J. (2009) Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase. PNAS . 106(50):21191-6.
8. Zhang L, Ren F, Zhang Q, Chen Y, Wang B, Jiang J. (2008) The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control. Dev Cell. 14, 377-387.
9. Zhang Q, Zhang L, Wang B, Ou CY, Chien CT, Jiang J. (2006) A Hedgehog-induced BTB protein modulates Hedgehog signaling responses by degrading Ci/Gli transcription factor. Dev Cell. 10, 719-729.
10. Jia J, Zhang L, Zhang Q, Tong C, Wang B, Hou F, Amanai K, Jiang J. (2005) Phosphorylation of Cubitus interruptus by Double-time/CKIe and CKIa targets it for Slimb/b-TRCP mediated proteolytic processing. Dev Cell. 9, 819-830.
团队风采 |