南京大学生命科学学院教授、博士生导师
地址:南京市栖霞区仙林大道163号
邮箱:qzhao@nju.edu.cn
研究领域 |
1. 基因转录及表观遗传学调控机制;
2. 癌症的发生机理与防治研究
工作经历 |
2006-至今,南京大学 生命科学学院
2002-2006,澳大利亚皇家墨尔本医院 骨髓研究所
1988-1998,南京大学医学院临床学院金陵医院
荣誉奖励 |
2013,江苏省“333高层次人才培养工程”第二层次人才
2010,南京领军型科技创业人才
2008,南京大学“优秀中青年学科带头人”
2007,教育部“新世纪优秀人才支持计划”
2006,Cooley's Anemia Foundation Research Fellowship, USA,
1999,江苏省科学技术进步二等奖
学术任职 |
中国生物化学与分子生物学学会理事;
江苏省生物化学与分子生物学学会副理事长
代表性成果 |
[1] Li X, Chen M, Liu B, Lu P, Lv X, Zhao X, Cui S, Xu P, Nakamura Y, Kurita R, Chen B, Huang DCS, Liu DP, Liu M, Zhao Q*. Transcriptional silencing of fetal hemoglobin expression by NonO. Nucleic Acids Res. 2021,49(17):9711-9723. (*Corresponding author)
原文链接:https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/gkab671
[2] Gui T, Liu M, Yao B, Jiang H, Yang D, Li Q, Zeng X, Wang Y, Cao J, Deng Y, Li X, Xu P, Zhou L, Li D, Wang Z, Zen K, Huang DCS, Chen B, Wan G, Zhao Q*. TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer. Cell Death Differ. 2021, 28(12):3316-3328
原文链接:https://www.nature.com/articles/s41418-021-00824-w
[3] Yao B, Gui T, Zeng X, Deng Y, Wang Z, Wang Y, Yang D, Li Q, Xu P, Hu R, Li X, Chen B, Wang J, Zen K, Li H, Davis MJ, Herold MJ, Pan HF, Jiang ZW, Huang DCS, Liu M, Ju J, Zhao Q*. PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling. Genome Med. 2021,13(1):58
原文链接:https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-021-00871-5
[4] Liu M, Yao B, Gui T, Guo C, Wu X, Li J, Ma L, Deng Y, Xu P, Wang Y, Yang D, Li Q, Zeng X, Li X, Hu R, Ge J, Yu Z, Chen Y, Chen B, Ju J, Zhao Q*. PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression. Theranostics. 2020,10(10): 4437–4452.
原文链接:https://www.thno.org/v10p4437
[5] Ju J, Chen A, Deng Y, Liu M, Wang Y, Wang Y, Nie M, Wang C, Ding H, Yao B, Gui T, Li X, Xu Z, Ma C, Song Y, Kvansakul M, Zen K, Zhang CY, Luo C, Fang M, Huang DCS, Allis CD, Tan R, Zeng CK, Wei J, Zhao Q*. NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression. Nat Commun. 2017,8(1):928.
原文链接:https://www.nature.com/articles/s41467-017-00988-5
[6] Liu M, Huang F, Zhang D, Ju J, Wu XB, Wang Y, Wang Y, Wu Y, Nie M, Li Z, Ma C, Chen X, Zhou JY, Tan R, Yang BL, Zen K, Zhang CY, Chen YG, Zhao Q*. Heterochromatin Protein HP1γ Promotes Colorectal Cancer Progression and Is Regulated by miR-30a. Cancer Res. 2015, 75(21): 4593-604.
[7] Ju J, Wang Y, Liu R, Zhang Y, Xu Z, Wang Y, Wu Y, Liu M, Cerruti L, Zou F, Ma C, Fang M, Tan R, Jane SM, Zhao Q*. Human fetal globin gene expression is regulated by LYAR. Nucleic Acids Res. 2014, 42(15):9740-52.
原文链接:https://academic.oup.com/nar/article/42/15/9740/2437395?login=true
[8] Rank G, Cerruti L, Moritz RL, Simpson RJ, Jane SM, Zhao Q*. Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression. Blood. 2010, 116(9):1585-92
[9] Zhao Q*, Rank G, Tan YT, Li H, Moritz RL, Simpson RJ, Cerruti L, Curtis DJ, Patel DJ, Allis CD, Cunningham JM, Jane SM. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing. Nat Struct Mol Biol. 2009, 16(3):304-11
原文链接:https://www.nature.com/articles/nsmb.1568
[10] Zhao Q, Wang J, Levichkin IV, Stasinopoulos S, Ryan MT, Hoogenraad NJ. A mitochondrial specific stress response in mammalian cells. EMBO J. 2002, 21(17):4411-9.
原文链接:https://www.embopress.org/doi/full/10.1093/emboj/cdf445