教授、博士生导师,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:zhuhl@nju.edu.cn
研究领域 |
天然药物合成化学
小分子生物传感与成像
低毒性肿瘤诊疗纳米递药系统
工作经历 |
1998-2000,中山大学博士后
2000-2001,马尔堡菲利普斯大学博士后
2002-2004,武汉纺织大学教授
2004-至今,南京大学教授
荣誉奖励 |
2018,淮河流域闸坝型河流废水再生利用与风险控制关键技术研发与应用,环保部环境保护科学技术奖,一等奖。
2016,甘草酸系列产品纯化及结构修饰技术,中国商业联合会科技进步,一等奖。
学术任职 |
2009-至今,Anti-cancer. Agent. Med. Chem.副主编。
代表性成果 |
著作:
Shashikant Teaiya, Hai-Liang Zhu (主编). TBA-HS Catalysed Domino Reaction. Lambert Academic Publishing, 2014, Salbruken, Germany, Page 1-157.
论文:
1. Qi, Y.-L.; Wang, H.-R.; Chen, L.-L.; Duan, Y.-T.; Yang, S.-Y.; Zhu, H.-L., Recent advances in small-molecule fluorescent probes for studying ferroptosis. Chemical Society Reviews 2022, 51 (18), 7752-7778.
2. Wang, K.; Wang, W.; Chen, X.-Y.; Yang, Y.-S.; Zhu, H.-L., Constructing a novel fluorescence detection method for γ-glutamyltranspeptidase and application on visualizing liver injury. Biosensors and Bioelectronics 2023, 219, 114767.
3. Zhang, B.; Li, X.; Shu, W.; Yang, Y.-S.; Zhu, H.-L.; Shao, C., A self-supplied O2 versatile nanoplatform for GOx-mediated synergistic starvation and hypothermal photothermal therapy. Materials & Design 2022, 222, 111067.
4. Wang, K.; Yang, X.; Guo, M.-Y.; Chen, X.-Y.; Li, T.; Yan, R.; Yang, Y.-S.; Zhu, H.-L.; Hu, Z.-G., Imaging the dynamic processes of hydrogen sulfide using a rapid “turn-on” mitochondria-targeting fluorescent probe. Sensors and Actuators B: Chemical 2022, 369, 132285.
5. Shao, C.; Liu, Y.; Chen, Z.; Qin, Y.; Wang, X.; Wang, X.; Yan, C.; Zhu, H.-L.; Zhao, J.; Qian, Y., 3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis. Cell Chemical Biology 2022, 29 (1), 43-56.e12.
6. Shao, C.; Wu, J.; Han, S.; Liu, Y.; Su, Z.; Zhu, H.-L.; Liu, H.-K.; Qian, Y., Biotinylated curcumin as a novel chemosensitizer enhances naphthalimide-induced autophagic cell death in breast cancer cells. European Journal of Medicinal Chemistry 2022, 228, 114029.
7. Jin, C.; Wu, P.; Yang, Y.; He, Z.; Zhu, H.; Li, Z., A novel fluorescent probe for the detection of peroxynitrite and its application in acute liver injury model. Redox Biology 2021, 46, 102068.
8. Ren, S.-Z.; Wang, B.; Zhu, X.-H.; Zhu, D.; Liu, M.; Li, S.-K.; Yang, Y.-S.; Wang, Z.-C.; Zhu, H.-L., Oxygen Self-Sufficient Core–Shell Metal–Organic Framework-Based Smart Nanoplatform for Enhanced Synergistic Chemotherapy and Photodynamic Therapy. ACS Applied Materials & Interfaces 2020, 12 (22), 24662-24674.
9. Chenwen Shao, Jiwen Yuanb, Yani Liu, Yajuan Qin, Xueao Wang, Jin Gu, Guiquan Chen, Bing Zhang, Hong-Ke Liu, Jing Zhao, Hai-Liang Zhu and Yong Qian. Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis. PNAS. 2020, 117(19), 10155-10164.
10. Jian Chen, Chenwen Shao, Xueao Wang, Jin Gu, Hai-Liang Zhu and Yong Qian. Imaging of formaldehyde fluxes in epileptic brains with a two-photon fluorescence probe. Chem. Commun. 2020, 56, 3871-3874.
团队风采 |