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  • 朱海亮

教授、博士生导师,医药生物技术国家重点实验室

地址:南京市栖霞区仙林大道163号,210023

邮箱:zhuhl@nju.edu.cn









研究领域


天然药物合成化学

小分子生物传感与成像

低毒性肿瘤诊疗纳米递药系统


工作经历


1998-2000,中山大学博士后

2000-2001,马尔堡菲利普斯大学博士后

2002-2004,武汉纺织大学教授

2004-至今,南京大学教授



荣誉奖励


2018,淮河流域闸坝型河流废水再生利用与风险控制关键技术研发与应用,环保部环境保护科学技术奖,一等奖。

2016,甘草酸系列产品纯化及结构修饰技术,中国商业联合会科技进步,一等奖。



学术任职


2009-至今,Anti-cancer. Agent. Med. Chem.副主编。




代表性成果

著作:

Shashikant Teaiya, Hai-Liang Zhu (主编). TBA-HS Catalysed Domino Reaction. Lambert Academic Publishing, 2014, Salbruken, Germany, Page 1-157.

论文:

1.    Qi, Y.-L.;  Wang, H.-R.;  Chen, L.-L.;  Duan, Y.-T.;  Yang, S.-Y.; Zhu, H.-L., Recent advances in small-molecule fluorescent probes for studying ferroptosis. Chemical Society Reviews 2022, 51 (18), 7752-7778.

2.    Wang, K.;  Wang, W.;  Chen, X.-Y.;  Yang, Y.-S.; Zhu, H.-L., Constructing a novel fluorescence detection method for γ-glutamyltranspeptidase and application on visualizing liver injury. Biosensors and Bioelectronics 2023, 219, 114767.

3.    Zhang, B.;  Li, X.;  Shu, W.;  Yang, Y.-S.;  Zhu, H.-L.; Shao, C., A self-supplied O2 versatile nanoplatform for GOx-mediated synergistic starvation and hypothermal photothermal therapy. Materials & Design 2022, 222, 111067.

4.    Wang, K.;  Yang, X.;  Guo, M.-Y.;  Chen, X.-Y.;  Li, T.;  Yan, R.;  Yang, Y.-S.;  Zhu, H.-L.; Hu, Z.-G., Imaging the dynamic processes of hydrogen sulfide using a rapid “turn-on” mitochondria-targeting fluorescent probe. Sensors and Actuators B: Chemical 2022, 369, 132285.

5.    Shao, C.;  Liu, Y.;  Chen, Z.;  Qin, Y.;  Wang, X.;  Wang, X.;  Yan, C.;  Zhu, H.-L.;  Zhao, J.; Qian, Y., 3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis. Cell Chemical Biology 2022, 29 (1), 43-56.e12.

6.    Shao, C.;  Wu, J.;  Han, S.;  Liu, Y.;  Su, Z.;  Zhu, H.-L.;  Liu, H.-K.; Qian, Y., Biotinylated curcumin as a novel chemosensitizer enhances naphthalimide-induced autophagic cell death in breast cancer cells. European Journal of Medicinal Chemistry 2022, 228, 114029.

7.    Jin, C.;  Wu, P.;  Yang, Y.;  He, Z.;  Zhu, H.; Li, Z., A novel fluorescent probe for the detection of peroxynitrite and its application in acute liver injury model. Redox Biology 2021, 46, 102068.

8.    Ren, S.-Z.;  Wang, B.;  Zhu, X.-H.;  Zhu, D.;  Liu, M.;  Li, S.-K.;  Yang, Y.-S.;  Wang, Z.-C.; Zhu, H.-L., Oxygen Self-Sufficient Core–Shell Metal–Organic Framework-Based Smart Nanoplatform for Enhanced Synergistic Chemotherapy and Photodynamic Therapy. ACS Applied Materials & Interfaces 2020, 12 (22), 24662-24674.

9. Chenwen Shao, Jiwen Yuanb, Yani Liu, Yajuan Qin, Xueao Wang, Jin Gu, Guiquan Chen, Bing Zhang, Hong-Ke Liu, Jing Zhao, Hai-Liang Zhu and Yong Qian. Epileptic brain fluorescent imaging reveals apigenin can relieve the myeloperoxidase-mediated oxidative stress and inhibit ferroptosis. PNAS2020117(19), 10155-10164. 

10. Jian Chen, Chenwen Shao, Xueao Wang, Jin Gu, Hai-Liang Zhu and Yong Qian. Imaging of formaldehyde fluxes in epileptic brains with a two-photon fluorescence probe. Chem. Commun202056, 3871-3874.


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