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  • 朱敏生

教授、中国细胞生物学会理事、江苏省发育生物学会监事,医药生物技术国家重点实验室 

地址:南京市栖霞区仙林大道163号,210023

邮箱:zhums@nju.edu.cn









研究领域


肠道微生物与平滑肌生理学



工作经历


1999-2001年间在美国德州大学西南医学中心生理系从事博士后研究

2004年至今在南京大学任教授



荣誉奖励


2016年国家科技进步二等奖(第2完成人)暨教育部科技进步特等奖(第2完成人)一项基因工程小鼠等相关疾病模型研发与应用



代表性成果

[1] Zhou YW, Sun J, Wang Y, Chen CP, Tao T, Ma M, Chen X, Zhang XN, Yang LY, Zhang ZL, Li YQ, Jiang ZH, Qiu TT, Wang H, Pan Y, Zhang J, Chen HQ, Wang P, Zhu MS. Tas2R activation relaxes airway smooth muscle by release of Gαt targeting on AChR signaling. Proc. Natl. Acad. Sci. U.S.A. 2022 Jun 28;119(26):e2121513119. 

原文链接:https://doi.org/10.1073/pnas.2121513119

[2] Chen X, Qiu TT, Wang Y, Xu LY, Sun J, Jiang ZH, Zhao W, Tao T, Zhou YW, Wei L, Li Y, Zheng Y, Zhou GH, Chen H, Zhang J, Feng XB, Wang F, Li N, Zhang XN, Jiang J, Zhu MS. A Shigella sp. variant is causally linked to intractable functional constipation. J Clin Invest. 2022 May 26:e150097. 

原文链接:https://doi.org/10.1172/JCI150097.

[3] Zheng YY, Wang Y, Chen X, Wei LS, Wang H, Tao T, Zhou YW, Jiang ZH, Qiu TT, Sun ZY, Sun J, Wang P, Zhao W, Li YQ, Chen HQ, Zhu MS, Zhang XN. The thymus regulates skeletal muscle regeneration by directly promoting satellite cell expansion. J Biol Chem. 2022 Jan;298(1):101516. doi: 10.1016/j.jbc.2021.101516.

原文链接:https://doi.org/10.1016/j.jbc.2021.101516 

[4] Chen X, Yun-Qian Gao, Yan-Yan Zheng, Wei Wang, Pei Wang, Juan Liang, Wei Zhao, Tao Tao, Jie Sun, Li-Sha Wei, Ye-Qiong Li, Yu-Wei Zhou, Zhen-Ji Gan, Xue-Na Zhang, Hua-Qun Chen, Min-Sheng Zhu* Intragenic MIR199A1 in the DNM2 gene contributes to the pathology of X-linked centronuclear myopathy. J Biol Chem 2020 Jun 26;295(26):8656-8667.

原文链接:https://doi.org/10.1074/jbc.RA119.010839

[5] Sun J, Tao T, Zhao W, Wei LS, She F, Wang P, Li Y, Zheng Y, Chen X, Wang W, Qiao YN, Zhang XN, Zhu MS*. CPI-17-mediated contraction of vascular smooth muscle is essential for the development of hypertension in obese mice. J Genet Genomics 2019;46(3):109-118

原文链接:https://doi.org/10.1016/j.jgg.2019.02.005

[6] Tao T, Sun J, Peng YJ, Li Y, Wang P, Chen X, Zhao W, Zheng YY, Wei LS, Wang W, Zhou YW, Liu J, Shi YS Zhu MS* Golgi-resident TRIO regulates membrane trafficking during neurite outgrowth. J Biol Chem 2019;294(28):10954-10968

原文链接:https://doi.org/10.1074/jbc.RA118.007318

[7] Pei Wang, Wei Zhao, Jie Sun, Tao Tao, Xin Chen, Yan-Yan Zheng, Cheng-Hai Zhang, Zhong Chen, Yun-Qian Gao, Fan She, Ye-Qiong Li, Li-Sha Wei, Ping Lu, Cai-Ping Chen, Ji Zhou, Da-Quan Wang, Liang Chen, Xiao-Hao Shi, Linhong Deng, Ronghua ZhuGe, Hua-Qun Chen, Min-Sheng Zhu*. Inflammatory Mediators Mediate Airway Smooth Muscle Contraction through a GPCR-TMEM16A-VDCC Axis and Contribute to Bronchial Hyperresponsiveness in Asthma. J Allergy Clin Immunol 2018;141(4):1259-1268

原文链接: https://doi.org/10.1016/j.jaci.2017.05.053

[8] Zhang CH, Wang P, Chen CP, Zhao W, Chen X, Chen C, He WQ, Qiao YN, Tao T, Sun J, Peng YJ, Craige SM, Lifshitz LM, Jr KJF, Fogarty KE, ZhuGe R, Zhu MS* The molecular basis underlying the genesis of basal tone in internal anal sphincter. Nature Communication. 20167:11358.

原文链接:https://www.nature.com/articles/ncomms11358 

[9] Gao YQ, Chen X, Wang P, Lu L, Zhao W, Chen C, Chen CP, Tao T, Sun J, Zheng YY, Du Jie, Li CJ, Gan ZJ, Gao X, Chen HQ and Zhu MS*. Regulation of DLK1 by the maternally expressed miR-379-544 cluster may underlie Callipyge polar overdominance inheritance. Proc. Natl. Acad. Sci. U.S.A. 2015; 112(44):13627-32

原文链接:https://doi.org/10.1073/pnas.1511448112

[10] Chen, C.P., Chen, X., Qiao, Y.N., Wang, P., He, W. Q., Zhang, C.H., Zhao, W., Gao, Y.Q., Chen, C., Tao, T., Sun, J., Wang, Y., Gao, N., Kamm, K.E., Stull, J.T., and Zhu, M.S * Roles in vivo for Myosin Phosphatase Targeting Subunit-1 T694 and T852 Phosphorylation sites in Bladder Smooth Muscle. J. Physiology 2015;593(3):681-700

原文链接:https://doi.org/10.1113/jphysiol.2014.283853


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