教授,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:boxwxy@nju.edu.cn
研究领域 |
抗肿瘤药物设计及作用机理;抗阿尔兹海默症药物设计及作用机理
工作经历 |
2014-,南京大学博士生导师
2015-,南京大学教授
荣誉奖励 |
2015,信号分子、核酸及蛋白的识别与调控研究,教育部2015年度高等学校科学研究优秀成果自然科学一等奖
学术任职 |
2020-,《Pharmaceutics》(IF: 6.525)编委
代表性成果 |
[1] T. Yang, L. Zhang, Y. C. Shang, Z. Z. Zhu, S. X. Jin*, Z. J. Guo, X. Y. Wang*. Concurrent suppression of Aβ aggregation and NLRP3 inflammasome activation for treating Alzheimer’s disease. Chem. Sci. 2022, 13, 2971‒2980.
[2] Y. Guo, S. X. Jin*, H. Yuan, T. Yang, K. Wang, Z. J. Guo*, X. Y. Wang*. DNA-unresponsive platinum(II) complex induces ERS-mediated mitophagy in cancer cells. J. Med. Chem. 2022, 65, 520−530.
[3] Y. J. Wang, X. C. Shi, H. B. Fang, Z. Han, H. Yuan, Z. Z. Zhu, L. Dong, Z. J. Guo, X. Y. Wang*. Platinum-based two-photon photosensitizer responsive to NIR light in tumor hypoxia microenvironment. J. Med. Chem. 2022, 65, 7786−7798.
[4] H. Z. Qiao,* L. Zhang, D. Fang, Z. Z. Zhu, W. J. He, L. H. Hu, L. Q. Di, Z. J. Guo, X. Y. Wang*. Surmounting tumor resistance to metallodrugs by co-loading a metal complex and siRNA in nanoparticles, Chem. Sci. 2021, 12, 4547‒4556.
[5] S. X. Jin, N. Muhammad, Y. W. Sun, Y. H. Tan, H. Yuan, D. F. Song, Z. J. Guo*, X. Y. Wang*. Multispecific platinum(IV) complex deters breast cancer via interposing inflammation and immunosuppression as an inhibitor of COX-2 and PD-L1. Angew. Chem. Int. Ed. 2020, 59, 23313‒23321.
[6] S. R. Zhang, X. M. Zhong, H. Yuan, Y. Guo, D. F. Song, F. Qi, Z. Z. Zhu, X. Y. Wang*, Z. J. Guo*. Interfering in apoptosis and DNA repair of cancer cells to conquer cisplatin resistance by platinum(IV) prodrugs. Chem. Sci. 2020, 11, 3829‒3835.
[7] K. Wang, C. C. Zhu, Y. F. He, Z. Q. Zhang, W. Zhou, N. Muhammad, Y. Guo, X. Y. Wang*, Z. J. Guo*. Restraining cancer cells by dual metabolic inhibition with a mitochondrion-targeted platinum(II) complex. Angew. Chem. Int. Ed.2019, 58, 4638‒4643.
[8] Z. Z. Zhu, Z. H. Wang, C. L. Zhang, Y. J. Wang, H. M. Zhang, Z. J. Gan, Z. J. Guo*, X. Y. Wang*. Mitochondrion-targeted platinum complexes suppressing lung cancer through multiple pathways involving energy metabolism, Chem. Sci. 2019, 10, 3089‒3095.
[9] T. Yang, Z. Z. Zhu, E. M. Yin, Y. Q. Wang, C. L. Zhang, H. Yuan, H. M. Zhang, S. X. Jin, Z. J. Guo, X. Y. Wang*. Alleviation of symptoms of Alzheimer’s disease by diminishing Aβ neurotoxicity and neuroinflammation, Chem. Sci.2019, 10, 10149‒10158.
[10] X. H. Wang, X. Y. Wang*, S. X. Jin, N. Muhammad, Z. J. Guo*. Stimuli-responsive therapeutic metallodrugs. Chem. Rev. 2019, 119, 1138‒1192.