教授,博导,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:likuanyu@nju.edu.cn
研究领域 |
铁代谢与线粒体功能
具体包括:
线粒体的铁代谢与神经退行性疾病
铁代谢/铁死亡与肿瘤
铁代谢与红系发育
铁代谢与动脉粥样硬化
工作经历 |
2011-至今,南京大学博士生导师
2009-至今,南京大学教授
2004-2009,美国国家卫生研究所(NIH),访问学者
2001-2004,德国Justus-Liebig大学,博士后
1999-2001,德国Justus-Liebig大学,DAAD奖学金交流学者
1998-1999,南京大学生科院副教授
1995-1998,南京大学生科院讲师
荣誉奖励 |
2021年南京大学医学院优秀博导
2019年度南京大学本科生实践教学优秀指导教师
2019年教育部自然科学奖二等奖
2017年江苏省医学科技奖三等奖
2008 Finalist of Mentor of NICHD Year Award, NIH
2008 FARE Award in NIH
2007 Fellow Award of Research Excellence (FARE Award) in NIH
2005 Travel Award for young scientist in Gordon Research Conference (GRC)
学术任职 |
2022-2025 生物物理学会微量元素分会副会长
2018-2021 生物物理学会微量元素分会副秘书长
代表性成果 |
1. Xu T, Cai J, Wang L, Xu L, Zhao H, Wang F, Meyron-Holtz EG, Missirlis F, Qiao T, Li K. Hormone replacement therapy for postmenopausal atherosclerosis is offset by late age iron deposition. Elife. 2023 Aug 10:12:e80494
2. Zhao H., Zhang M., Zhang J, Sun Z, Zhang W, Dong W, Cheng C, Yao Y*, Li K*. Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth. Cell Biosci 2023 May 13;13(1):87. doi: 10.1186/s13578-023-01044-0
3. Xu L, Sun Z, Xing Z, Liu Y, Zhao H, Tang Z, Luo Y, Hao S, Li K*. Cur@SF NPs alleviate Friedreich's ataxia in a mouse model through synergistic iron chelation and antioxidation. J Nanobiotechnology. 2022 Mar 9;20(1):118.
4. Pan Y, Li J, Xia X, Wang J, Jiang Q, Yang J, Dou H, Liang H*, Li K*, Hou Y*. β-glucan-coupled superparamagnetic iron oxide nanoparticles induce trained immunity to protect mice against sepsis. Theranostics. 2022 Jan 1;12(2):675-688.
5. Cai J, Zhang M, Liu Y, Li H, Shang L, Xu T, Chen Z, Wang F, Qiao T, Li K*. Iron accumulation in macrophages promotes the formation of foam cells and development of atherosclerosis. Cell Biosci. 2020 Nov 26;10(1):137
6. Li H, Liu Y, Shang L, Cai J, Wu J, Zhang W, Pu X, Dong W, Qiao T, Li K*. Iron regulatory protein 2 modulates the switch from aerobic glycolysis to oxidative phosphorylation in mouse embryonic fibroblasts. Proc Natl Acad Sci USA. 2019 May 14;116(20):9871-9876
7. Truman-Rosentsvit M, Berenbaum D, Spektor L, Cohen LA, Belizowsky-Moshe S, Lifshitz L, Ma J, Li W, Kesselman E, Abutbul-Ionita I, Danino D, Gutierrez L, Li H, Li K, Lou H, Regoni M, Poli M, Glaser F, Rouault TA, Meyron-Holtz EG*. Ferritin is secreted via 2 distinct nonclassical vesicular pathways. Blood. 2018 Jan 18;131(3):342-352.
8. Li K, Tong WH, Hughes RM, Rouault TA*. Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly.J Biol Chem. 2006 281(18):12344-51.
9. Li K, Pasternak C, Härtig E, Haberzettl K, Maxwell A, Klug G*. Thioredoxin can influence gene expression by affecting gyrase activity.2004. Nucleic Acids Res. 32(15):4563-75.
团队风采 |