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  • 高慧明

教授,医药生物技术国家重点实验室 

地址:南京市栖霞区仙林大道163号,210023

邮箱:gaohm@nju.edu.cn








研究领域


神经生物和神经免疫


工作经历


2013-至今    南京大学教授博士生导师

2009–1012   Research Fellow,神经生物学实验室,美国国立环境卫生科学研究院,北卡罗莱那州

2007–2008   博士后,毒理和药理实验室,美国国立环境卫生科学研究院,北卡罗莱那州

2004–2006   博士后,神经退行性疾病研究中心病理和实验医学系,宾西法尼亚大学医学院,费城,美国 

    

荣誉奖励


2003,卓越研究员学术研究奖,美国国家卫生研究院

2012,卓越研究员学术研究奖,美国国家卫生研究院

2013,江苏省高层次创新创业人才引进计划专项奖

2015,帕金森病发病机制及药物干预作用研究,贵州省科技进步二等奖(排名第三)


学术任职


2020-,中国神经科学学会神经胶质细胞分会第四届委员会委员



代表性成果

[1] R. Yang, Y. Gao, Hui Li, W. Huang, D. Tu, M. Yang, X. Liu, J.-S. Hong and H.-M. Gao* (2022) Posttranslational S-nitrosylation modification regulates HMGB1 secretion and promotes its pro-inflammatory and neurodegenerative effects. Cell Reports (in press)

[2] D. Liu, Y. Zhao, Y. Qi, Y. Gao, D. Tu, Y. Wang, H.-M. Gao* and H. Zhou* (2020) Benzo(a)pyrene exposure induced neuronal loss, plaque deposition, and cognitive decline in APP/PS1 mice. Journal of Neuroinflammation 17(1):258.

[3]  D. Tu, Y. Gao, R. Yang, T. Guan, J.-S. Hong and H.-M. Gao* (2019) The pentose phosphate pathway regulates chronic neuroinflammation and dopaminergic neurodegeneration. Journal of Neuroinflammation 16:255

[4]  C.H. Chu, S. Wang, C. L. Li, S. H. Chen, C. F. Hu, Y. L. Chung, S. L. Chen, Q. Wang, R. B. Lu, H.-M. Gao*, J. S. Hong (2016) Neurons and astroglia govern microglial endotoxin tolerance through macrophage colony-stimulating factor receptor-mediated ERK1/2 signals. Brain, Behavior, and Immunity 55: 260–272

[5]  H. Zhou, J. Liao, J. Aloor, H. Nie, B. Wilson, M. Fessler, H.-M. Gao*, J.-S. Hong (2013) CD11b/CD18 (Mac-1) is a novel surface receptor for extracellular double-stranded RNA to mediate cellular inflammatory responses. Journal of Immunology 190:115-125 (杂志重点推荐)

[6] H.-M. Gao*, H. Zhou, J.-S. Hong (2012) NADPH oxidases: novel therapeutic targets for neurodegenerative diseases. Trends in Pharmacological Sciences 33(6): 295-303 

[7]  H. Zhou, F. Zhang, S. H. Chen, D. Zhang, B. Wilson, J.-S. Hong, H.-M. Gao* (2012) Rotenone activates phagocyte NADPH oxidase through binding to its membrane subunit gp91phox. Free Radical Biology & Medicine 52: 303–313. 

[8]  H.-M. Gao*, H. Zhou, F. Zhang, B. Wilson, W. Kam, J.-S. Hong (2011) HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration. Journal of Neuroscience. 31(3):1081–1092 

[9]  H.-M. Gao, P. T. Kotzbauer, K. Uryu, S. Leight, J. Q. Trojanowski, V. M. Lee. (2008) Neuroinflammation and oxidation/nitration of α-synuclein linked to dopaminergic neurodegeneration. Journal of Neuroscience. 28(30):7687–7698 

[10] H.-M. Gao* and J.-S. Hong (2008) Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression. Trends in Immunology 29: 357-365(封面插图)


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