副教授,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:borisguo@nju.edu.cn
研究领域 |
肌肉、骨骼及关节退化性疾病的转化医学研究
工作经历 |
2018-,南京大学 副教授,博导
2015-2018,香港浸会大学 研究助理教授
2012-2015,香港浸会大学 博士后
2009-2012,香港中文大学,博士(Ph.D.)
2008-2009,香港理工大学 研究助理
荣誉奖励 |
2013,香港中文大学优秀青年学者学位论文奖
2011,美国骨矿研究学会(ASBMR)青年研究学者奖
2010,中华医学会骨质疏松及骨矿盐疾病分会暨国际华人骨研学会(ICMRS),Web Jee Travel Award
学术任职 |
2021-2025,中国医师协会骨科医师分会第五届委员会骨科基础学组委员
2019-2023,中国老年学和老年医学学会老年骨科分会创新转化学组第一届委员
2015-2019,中华中医药学会免疫学分会委员
代表性成果 |
[1] Chen X¶, Zhang L¶, Shao X, Gong W, Shi T, Dong J, Shi Y, Shen S, He Y, Qin J, Lu J, Jiang Q*, Guo B*. Specific Clearance of Senescent Synoviocytes Suppresses the Development of Osteoarthritis based on Aptamer-Functionalized Targeted Drug Delivery System., Adv. Funct. Mater. 2022, 32, 2109460. https://doi.org/10.1002/adfm.202109460
[2] Zhang L¶, Chen X¶, Cai P*, Sun H, Shen S, Guo B*, Jiang Q*. Reprogramming Mitochondrial Metabolism in Synovial Macrophages of Early Osteoarthritis by a Camouflaged Meta-Defensome. Adv Mater. 2022 Jul; 34(30):e2202715. doi:10.1002/adma.202202715.
[3] Chen X¶, Gong W¶, Shao X, Shi T, Zhang L, Dong J, Shi Y, Shen S, Qin J, Jiang Q*, Guo B*. METTL3-mediated m6A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression. Ann Rheum Dis. 2021 Oct 27:annrheumdis-2021-221091. doi: 10.1136/annrheumdis-2021-221091.
[4] Gong W, Chen X, Shi T, Shao X, An X, Qin J, Chen X, Jiang Q*, Guo B*. Network Pharmacology-Based Strategy for the Investigation of the Anti-Osteoporosis Effects and Underlying Mechanism of Zhuangguguanjie Formulation. Front Pharmacol. 2021 Oct 1;12:727808. doi: 10.3389/fphar.2021.727808.
[5] Liu J¶, Dang L¶, Li D, Liang C, He X, Wu H, Qian A, Yang Z, Au DW, Chiang MW, Zhang BT, Han Q, Yue KK, Zhang H, Lv C, Pan X, Xu J, Bian Z, Shang P, Tan W, Liang Z, Guo B*, Lu A*, Zhang G*. A delivery system specifically approaching bone resorption surfaces to facilitate therapeutic modulation of microRNAs in osteoclasts. Biomaterials. 2015 Jun;52:148-60. doi: 10.1016/j.biomaterials.2015.02.007.
[6] Guo B¶, Zhang B¶, Zheng L, Tang T, Liu J, Wu H, Yang Z, Peng S, He X, Zhang H, Yue KK, He F, Zhang L, Qin L, Bian Z, Tan W, Liang Z, Lu A*, Zhang G*. Therapeutic RNA interference targeting CKIP-1 with a cross-species sequence to stimulate bone formation. Bone. 2014 Feb;59:76-88. doi: 10.1016/j.bone.2013.11.007.
[7] Liang C¶, Guo B¶, Wu H¶, Shao N, Li D, Liu J, Dang L, Wang C, Li H, Li S, Lau WK, Cao Y, Yang Z, Lu C, He X, Au DW, Pan X, Zhang BT, Lu C, Zhang H, Yue K, Qian A, Shang P, Xu J, Xiao L, Bian Z, Tan W, Liang Z, He F, Zhang L*, Lu A*, Zhang G*. Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference-based bone anabolic strategy. Nat Med. 2015 Mar;21(3):288-94. doi: 10.1038/nm.3791.
[8] Wang X¶, Guo B¶, Li Q, Peng J, Yang Z, Wang A, Li D, Hou Z, Lv K, Kan G, Cao H, Wu H, Song J, Pan X, Sun Q, Ling S, Li Y, Zhu M, Zhang P, Peng S, Xie X, Tang T, Hong A, Bian Z, Bai Y, Lu A, Li Y, He F, Zhang G*, Li Y*. miR-214 targets ATF4 to inhibit bone formation. Nat Med. 2013 Jan;19(1):93-100. doi: 10.1038/nm.3026.
[9] Zhang G*, Guo B¶, Wu H¶, Tang T¶, Zhang BT¶, Zheng L, He Y, Yang Z, Pan X, Chow H, To K, Li Y, Li D, Wang X, Wang Y, Lee K, Hou Z, Dong N, Li G, Leung K, Hung L, He F, Zhang L*, Qin L*. A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy. Nat Med. 2012 Jan 29;18(2):307-14. doi:10.1038/nm.2617. PMID: 22286306.
[10] Guo BS, Cheung KK, Yeung SS, Zhang BT, Yeung EW. Electrical stimulation influences satellite cell proliferation and apoptosis in unloading-induced muscle atrophy in mice. PLoS One. 2012;7(1):e30348. doi: 10.1371/journal.pone.0030348.
团队风采 |