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  • 魏继武

教授,医药生物技术国家重点实验室 

地址:南京市栖霞区仙林大道163号,210023

邮箱:wjw@nju.edu.cn









研究领域


肿瘤生物治疗


工作经历


2009-,南京大学博士生导师



荣誉奖励


2018,南京大学我最喜爱的老师

2019,南京大学魅力导师


学术任职


2020-,江苏省病理生理学会监事会主席



代表性成果

1. Wang S, Wei J. Distinguishing the pros and cons of metabolic reprogramming in oncolytic virus immunotherapy. Int J Cancer. 2022 May 27. doi: 10.1002/ijc.34139.  

2.  Zuo S, Wei M, Xu T, Kong L, He B, Wang S, Wang S, Wu J, Dong J, Wei J. An engineered oncolytic vaccinia virus encoding a single-chain variable fragment against TIGIT induces effective antitumor immunity and synergizes with PD-1 or LAG-3 blockade.J Immunother Cancer. 2021 Dec;9(12):e002843. doi: 10.1136/jitc-2021-002843.

3.  Zhang H, Zhang Y, Dong J, Zuo S, Meng G, Wu J, Wei J*. Recombinant adenovirus expressing the fusion protein PD1PVR improves CD8+ T cell-mediated antitumor efficacy with long-term tumor-specific immune surveillance in hepatocellular carcinoma. Cell Oncol (Dordr). 2021 Sep 7. doi: 10.1007/s13402-021-00633-w.

4.  Zhang H, Zhang Y, Dong J, Li B, Xu C, Wei M, Wu J, Wei J*. Recombinant oncolytic adenovirus expressing a soluble PVR elicits long-term antitumor immune surveillance. Mol Ther Oncolytics. 2020 Nov 17;20:12-22. doi: 10.1016/j.omto.2020.11.001.

5. Zuo S, Wei M, He B, Chen A, Wang S, Kong L, Zhang Y, Meng G, Xu T, Wu J, Yang F, Zhang H, Wang S, Guo C, Wu J, Dong J, Wei J*. Enhanced antitumor efficacy of a novel oncolytic vaccinia virus encoding a fully monoclonal antibody against T-cell immunoglobulin and ITIM domain (TIGIT). EBioMedicine. 2021 Feb;64:103240. doi: 10.1016/j.ebiom.2021.103240.

6. Meng G, Li B, Chen A, Zheng M, Xu T, Zhang H, Dong J, Wu J, Yu D, Wei J*.  Targeting aerobic glycolysis by dichloroacetate improves Newcastle disease virus-mediated viro-immunotherapy in hepatocellular carcinoma. Br J Cancer. 2020 Jan;122(1):111-120. doi: 10.1038/s41416-019-0639-7.

7. Xia M, Luo D, Dong J, Zheng M, Meng G, Wu J, Wei J*. Graphene oxide arms oncolytic measles virus for improved effectiveness of cancer therapy. J Exp Clin Cancer Res. 2019 Sep 18;38(1):408. doi: 10.1186/s13046-019-1410-x. 

8. Zhang Y, Zhang H, Wei M, Mou T, Shi T, Ma Y, Cai X, Li Y, Dong J, Wei J*. Recombinant Adenovirus Expressing a Soluble Fusion Protein PD-1/CD137L Subverts the Suppression of CD8+ T Cells in HCC. Mol Ther. 2019 Nov 6;27(11):1906-1918. doi: 10.1016/j.ymthe.2019.07.019.

9. Meng G, Fei Z, Fang M, Li B, Chen A, Xu C, Xia M, Yu D, Wei J*. Fludarabine as an Adjuvant Improves Newcastle Disease Virus-Mediated Antitumor Immunity in Hepatocellular Carcinoma. Mol Ther Oncolytics. 2019 Mar 27;13:22-34. doi: 10.1016/j.omto.2019.03.004.  


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