副教授,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:shenyan@nju.edu.cn
研究领域 |
抗肿瘤药理,抗炎免疫药理
工作经历 |
2007-,南京大学副教授
2005-2007,南京大学讲师
荣誉奖励 |
2012,肿瘤转移的新分子靶点及其靶向药物的研究,高等学校科学研究优秀成果奖自然科学奖一等奖 (排名第9)
2015,南京大学中国银行青年教师成果一等奖
2019,炎症及相关疾病治疗的新靶点和新策略研究. 高等学校科学研究优秀成果奖自然科学奖一等奖 (排名第7)
学术任职 |
2014-,世界中醫藥學會聯合會中醫藥免疫專業委員會 理事
代表性成果 |
[1] Xue WW, Li X, Li WH, Wang YX, Jiang CF, Zhou L, Gao J, Yu Y, Shen Y*, Xu Q*. Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer. Signal Transduct Target Ther.2022 Feb 4;7(1):35.
原文链接:https://pubmed.ncbi.nlm.nih.gov/35115484/
[2] Minmin Fan, Jian Gao, Lin Zhou, Wenwen Xue, Yixuan Wang, Jingwei Chen, Wuhao Li, Ying Yu, Bo Liu, Yan Shen*, Qiang Xu*.Highly expressed SERCA2 triggers tumor cell autophagy and is a druggable vulnerability in triple-negative breast cancer. Acta Pharmaceutica Sinica B. In publish. 2022.
[3] Fan M, Chen JW, Gao J, Xue WW, Wang YX, Li WH, Zhou L, Li X, Jiang CF, Sun Y, Wu XF, Wu XD, Ge H, Shen Y*, Xu Q*. Triggering a switch from basal- to luminal-like breast cancer subtype by the small-molecule diptoindonesin G via induction of GABARAPL1. Cell Death Dis. 2020 Aug 15;11(8):635.
原文链接:https://pubmed.ncbi.nlm.nih.gov/32801338/
[4] Ma Y, Yuwen D, Chen JW, Zheng BF, Gao J, Fan M, Xue WW, Wang YX, Li WH, Shu Y, Xu Q*, Shen Y*, Exosomal transfer of cisplatin-induced miR-425-3p confers cisplatin resistance in NSCLC through activating autophagy. International Journal of Nanomedicine. 2019 Oct 7;14:8121-8132.
原文链接:https://pubmed.ncbi.nlm.nih.gov/31632022/
[5] Xiang G, Fan M, Ma Y, Wang M, Gao J, Chen J, Li X, Xue W, Wang Y, Gao H*, Shen Y*, Xu Q*. Anti-inflammatory actions of Caesalpinin M2 in experimental colitis as a selective glucocoricoid receptor modulator. Biochem Pharmacol. 2018;150:150-159.
原文链接:https://pubmed.ncbi.nlm.nih.gov/29427627/
[6] Gao J, Fan M, Peng S, Zhang M, Xiang G, Li X, Guo W, Sun Y, Wu X, Wu X, Liang G, Shen Y*, Xu Q*. Small molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer. Cell Death Dis. 2017 Sep 14;8(9):e3049.
原文链接:https://pubmed.ncbi.nlm.nih.gov/28906486/
[7] Gao J, Fan M, Xiang G, Wang J, Zhang X, Guo W, Wu X, Sun Y, Gu Y, Ge H, Tan R, Qiu H*, Shen Y*, Xu Q*. Diptoindonesin G promotes ERK-mediated nuclear translocation of p-STAT1 (Ser727) and cell differentiation in AML cells. Cell Death Dis. 2017 May 4;8(5):e2765.
原文链接:https://pubmed.ncbi.nlm.nih.gov/28471454/
[8] Elgehama, A. Chen W, Pang J, Mi S, Li J, Guo W, Wang X, Gao J, Yu B, Shen Y*, Xu Q*. Blockade of the interaction between Bcr-Abl and PTB1B by small molecule SBF-1 to overcome imatinib-resistance of chronic myeloid leukemia cells. Cancer Lett. 2016;372:82-88.
原文链接:https://pubmed.ncbi.nlm.nih.gov/26721204/
[9] Fang XY, Song R, Chen W, Yang YY, Gu YH, Shu YQ, Wu XD, Wu XF, Sun Y*, Shen Y*, Xu Q*. PRL-3 promotes the malignant progression of melanoma via triggering dephosphorylation and cytoplasmic localization of NHERF1. J Invest Dermatol, 2015, Sep;135(9):2273-82.
原文链接:https://pubmed.ncbi.nlm.nih.gov/25897829/
[10] 郑伟娟,沈燕,藏宇辉 编委.《分子生物学习题解析》,科学出版社,2013.
其他 |