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  • 沈燕

副教授,医药生物技术国家重点实验室 

地址:南京市栖霞区仙林大道163号,210023

邮箱:shenyan@nju.edu.cn









研究领域


抗肿瘤药理,抗炎免疫药理


工作经历


2007-,南京大学副教授

2005-2007,南京大学讲师



荣誉奖励


2012,肿瘤转移的新分子靶点及其靶向药物的研究,高等学校科学研究优秀成果奖自然科学奖一等奖 (排名第9

2015,南京大学中国银行青年教师成果一等奖

2019,炎症及相关疾病治疗的新靶点和新策略研究高等学校科学研究优秀成果奖自然科学奖一等奖 (排名第7


学术任职


2014-,世界中醫藥學會聯合會中醫藥免疫專業委員會 理事



代表性成果

[1] Xue WW, Li X, Li WH, Wang YX, Jiang CF, Zhou L, Gao J, Yu Y, Shen Y*, Xu Q*. Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer. Signal Transduct Target Ther.2022 Feb 4;7(1):35.

原文链接:https://pubmed.ncbi.nlm.nih.gov/35115484/

[2]  Minmin Fan, Jian Gao, Lin Zhou, Wenwen Xue, Yixuan Wang, Jingwei Chen, Wuhao Li, Ying Yu, Bo Liu, Yan Shen*, Qiang Xu*.Highly expressed SERCA2 triggers tumor cell autophagy and is a druggable vulnerability in triple-negative breast cancer. Acta Pharmaceutica Sinica B. In publish. 2022.

[3] Fan M, Chen JW, Gao J, Xue WW, Wang YX, Li WH, Zhou L, Li X, Jiang CF, Sun Y, Wu XF, Wu XD, Ge H, Shen Y*, Xu Q*. Triggering a switch from basal- to luminal-like breast cancer subtype by the small-molecule diptoindonesin G via induction of GABARAPL1. Cell Death Dis. 2020 Aug 15;11(8):635. 

原文链接:https://pubmed.ncbi.nlm.nih.gov/32801338/

[4] Ma Y, Yuwen D, Chen JW, Zheng BF, Gao J, Fan M, Xue WW, Wang YX, Li WH, Shu Y, Xu Q*, Shen Y*, Exosomal transfer of cisplatin-induced miR-425-3p confers cisplatin resistance in NSCLC through activating autophagy. International Journal of Nanomedicine. 2019 Oct 7;14:8121-8132. 

原文链接:https://pubmed.ncbi.nlm.nih.gov/31632022/

[5] Xiang G, Fan M, Ma Y, Wang M, Gao J, Chen J, Li X, Xue W, Wang Y, Gao H*, Shen Y*, Xu Q*. Anti-inflammatory actions of Caesalpinin M2 in experimental colitis as a selective glucocoricoid receptor modulator. Biochem Pharmacol. 2018;150:150-159.

原文链接:https://pubmed.ncbi.nlm.nih.gov/29427627/

[6] Gao J, Fan M, Peng S, Zhang M, Xiang G, Li X, Guo W, Sun Y, Wu X, Wu X, Liang G, Shen Y*, Xu Q*. Small molecule RL71-triggered excessive autophagic cell death as a potential therapeutic strategy in triple-negative breast cancer. Cell Death Dis. 2017 Sep 14;8(9):e3049. 

原文链接:https://pubmed.ncbi.nlm.nih.gov/28906486/

[7] Gao J, Fan M, Xiang G, Wang J, Zhang X, Guo W, Wu X, Sun Y, Gu Y, Ge H, Tan R, Qiu H*, Shen Y*, Xu Q*. Diptoindonesin G promotes ERK-mediated nuclear translocation of p-STAT1 (Ser727) and cell differentiation in AML cells. Cell Death Dis. 2017 May 4;8(5):e2765.

 原文链接:https://pubmed.ncbi.nlm.nih.gov/28471454/

[8] Elgehama, A. Chen W, Pang J, Mi S, Li J, Guo W, Wang X, Gao J, Yu B, Shen Y*, Xu Q*. Blockade of the interaction between Bcr-Abl and PTB1B by small molecule SBF-1 to overcome imatinib-resistance of chronic myeloid leukemia cells. Cancer Lett. 2016372:82-88.

原文链接:https://pubmed.ncbi.nlm.nih.gov/26721204/

[9] Fang XY, Song R, Chen W, Yang YY, Gu YH, Shu YQ, Wu XD, Wu XF, Sun Y*, Shen Y*, Xu Q*. PRL-3 promotes the malignant progression of melanoma via triggering dephosphorylation and cytoplasmic localization of NHERF1. J Invest Dermatol, 2015, Sep;135(9):2273-82. 

原文链接:https://pubmed.ncbi.nlm.nih.gov/25897829/

[10] 郑伟娟,沈燕,藏宇辉 编委.《分子生物学习题解析》,科学出版社,2013.


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