所在位置: 人才队伍 >> 研究人员 >>
  • 王小明

副教授,医药生物技术国家重点实验室 

地址:南京市栖霞区仙林大道163号,210023

邮箱:wangxm07@nju.edu.cn









研究领域


药物化学

化学生物学



工作经历


2006-2008,南京大学生命科学学院,博士后

2008-2013,南京大学生命科学学院,讲师

2020-2021,南京经济技术开发区组织人社局,副局长

2013-,南京大学生命科学学院,副教授

2017-,南京大学生命科学学院,硕士生导师




荣誉奖励


2017,江苏省“六大人才高峰”人才项目

2020,南京大学《生物化学》优秀教学团队奖(成员)

2021,第一届全国博士后创新创业大赛,铜奖(指导教师)

2021,第一届全国博士后创新创业大赛,优秀博士后

2021,南京市江苏省第十三批科技镇长团,优秀团员

2021,江苏省科技镇长团,荣誉团员称号



代表性成果

[1] T. Li, A. D. Zhou, L. F. Bai, X. Y. Zhang, Y. T. Zhou, H. L. Yang, L. T. Xu, X. Q. Guo, X. Y. Zhu, D. J. Wang*, H. W. Gu*, X. M. Wang*. Design, synthesis and anticancer activity of three novel palbociclib derivatives. Front. Oncol.2022, 25: DOI 10.3389/fonc.2022.959322

[2] W. X. Guo, Z. K. Shen, Y. F. Su, K. Li, J. Guan, X. M. Wang*, Z. S. Li*, Z. T. Yu *, Z. G. Zou. Iron-N-Heterocyclic Carbene Complexes as Efficient Electrocatalysts for Water Oxidation in Acidic Conditions. Dalton Trans. 2022, 51, 12494-12501.

[3] Y. Y. Ma, X. R. Yang, H. W. Han, Z. L. Wen, M. K. Yang, Y. H. Zhang, J. Y. Fu, X. Wang, T. M. Yin, G. H. Lu, J. L. Qi, H. Y. Lin*, X. M. Wang*, Y. H. Yang*. Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway, Bioorg. Chem. 2021, 111: 104872-104872.

[4] H. Y. Lin, H. W. Han, W. X. Sun, Y. S. Yang, G. H. Lu, J. L. Qi*, X. M. Wang*, Y. H. Yang*.  Design and characterization of α-lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors. Eur. J. Med. Chem.2018, 144: 137-150.

[5] H. Y. Qiu, J. Y. Fu, M. K. Yang, H. W. Han, P. F. Wang, Y. H. Zhang, H. Y. Lin, C. Y. Tang, J. L. Qi, R. W. Yang, X. M. Wang*, H. L. Zhu*, Y. H. Yang*. Identification of new shikonin derivatives as STAT3 inhibitors. Biochem. Pharmacol. 2017, 146, 74-86. 

[6] H. W. Han, C. S. Zheng, S. J. Chu, W. X. Sun, L. J. Han, R. W. Yang, J. L. Qi, G. H. Lu*, X. M. Wang*, Y. H. Yang*.The evaluation of potent antitumor activities of shikonin coumarin-carboxylic acid, PMMB232 through HIF-1alpha-mediated apoptosis. Biomed. Pharmacother. 2017, 97: 656-666. 

[7] H. Y. Qiu, P. F. Wang, Z. Li, J. T. Ma, X. M. Wang*, Y. H. Yang*, H. L. Zhu*. Synthesis of dihydropyrazole sulphonamide derivatives that act as anti-cancer agents through COX-2 inhibition. Pharmacol. Res. 2016, 104: 86-96.

[8] H. Y. Lin, Z. K. Li, L. F. Bai, K. S. Baloch, F. Wang, H. Y. Qiu, X. Wang, J. L. Qi, R. W. Yang, X. M. Wang*, Y. H. Yang*. Synthesis of phenyl thiazole acyl shikonin ester derivatives as anti-cancer agents through microtubule stabilization. Biochem. Pharmacol. 2015, 96(2), 93-106.

[9] H. Y. Lin, Z. K. Li, H. W. Han, H. Y. Qiu, H. W. Gu, Y. H. Yang*, X. M. Wang*. Synthesis of novel aryl dithian valeryl podophyllotoxin ester derivatives as potential anti-tubulin agents RSC Adv., 2015, 5(59), 47511-47521. 

[10] H. Y. Lin, L. F, Bai, F. Wang, X. Wu, L. J. Han, K. S. Baloch, Y. H. Yang*, X. M. Wang*. Semi-synthesis and anti-lung cancer activity evaluation of aryl thiazol acyl podophyllotoxin ester derivatives. RSC Adv., 2015, 5(35), 27775-27784.