所在位置: 人才队伍 >> 研究人员 >>
  • 吴旭东

教授,博导,医药生物技术国家重点实验室

地址:南京市仙林校区仙林大道163号,210023

邮箱:xudongwu@nju.edu.cn









研究领域


炎症及代谢性疾病的发病机制与新药发现

工作经历


2018-至今,南京大学生命科学学院 教授、博导

2011-2018,南京大学生命科学学院 副教授、硕导

2009-2011,南京大学生命科学学院 讲师



荣誉奖励


2022,江苏省高校教师教学创新大赛二等奖

2021,江苏省高校微课大赛三等奖

2021,江苏省青蓝工程优秀教学团队

2018,江苏省教育教学研究成果奖二等奖

2018,南京市自然科学优秀学术论文二等奖

2010,南京市自然科学优秀学术论文一等奖



学术任职


2018-至今,中国药理学会抗炎免疫专委会委员

2016-至今,Chinese Journal of Natural Medicines青年编委

2017-至今,江苏省生理科学学会理事




杂志任职

1. Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways. Wu Xudong, Zhang Luyong, Gurley Emily, Studer Elaine, Shang Jing, Wang Tao, Wang Cuifen, Yan Ming, Jiang Zhenzhou, Hylemon PB, Sanyal AJ, Pandak WM Jr, Zhou Huiping. Hepatology. 2008 Jun;47(6):1905-15.

2. HIV protease inhibitors induce endoplasmic reticulum stress and disrupt barrier integrity in intestinal epithelial cells. Wu Xudong, Sun Lixin, Zha Weibin, Studer Elaine, Gurley Emily, Chen Li, Wang Xuan, Hylemon PB, Pandak WM Jr, Sanyal AJ, Zhang Luyong, Wang Guangji, Chen Jie, Wang Jian-Ying, Zhou Huiping. Gastroenterology. 2010 Jan;138(1):197-209.

3. CUG-binding protein 1 regulates HSC activation and liver fibrogenesis. Wu Xingxin#Wu Xudong#,*, Ma Yuxiang, Shao Fenli, Tan Yang, Tan Tao, Gu Liyun, Zhou Yang, Sun Beicheng, Sun Yang, Wu Xuefeng, Xu Qiang*. Nature Communications. 2016 Nov 17; 7:13498. doi: 10.1038/ncomms13498. 

4. Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH.Fang Xu, Mengmeng Guo, Wei Huang, Lili Feng, Jiazhen Zhu, Kangkang Luo, Jian Gao, Bingfeng Zheng, Ling-Dong Kong, Tao Pang, Xudong Wu*, QiangXu*. Redox Biology. 2020 Sep; 36: 101634. doi.org/10.1016/j.redox.2020.101634  

5.Typically inhibiting USP14 promotes autophagy in M1-like macrophages and alleviates CLP-induced sepsis. Xu Fang, Ma Yuxiang, Huang Wei, Gao Jian, Guo Mengmeng, Li Jianxin, Kong Lingdong, Liang Guang, Du Ronghui, Xu Qiang*, Wu Xudong*. Cell Death & Diseases. 2020 Aug 20;11(8):666. doi: 10.1038/s41419-020-02898-9.  

6. Cis-khellactone inhibited the proinflammatory macrophages via promoting autophagy to ameliorate imiquimod-induced psoriasis. Feng Lili, Song Pingping, Xu Fang, Xu Lisha, Shao Fenli, Guo Mengmeng, Huang Wei, Kong Lingdong, Wu Xudong*, Xu Qiang*. Journal of Investigative Dermatology. 2019 Sep;139(9):1946-1956; doi: 10.1016/j.jid.2019.02.021.   

7. Seselin ameliorates inflammation via targeting Jak2 to suppress the proinflammatory phenotype of macrophages. Feng Lili, Sun Yi, Song Pingping, Xu Lisha, Wu Xingxin, Wu Xuefeng, Shen Yan, Sun Yang, Kong Lingdong, Wu Xudong*, Xu Qiang*. British Journal of Pharmacology. 2019 Jan;176(2):317-333. doi: 10.1111/bph.14521. 

8. HIV protease inhibitors in gut barrier dysfunction and liver injury. Wu Xudong, Li Yunzhou, Peng Kesong, Zhou Huiping. Current Opinions in Pharmacology. 2014 Dec;19: 61-6. doi: 10.1016/j.coph.2014.07.008.

9. A novel combination of astilbin and low-dose methotrexate respectively targeting A2AAR and its ligand adenosine for the treatment of collagen-induced arthritis. Ma Yuxiang, Gao Zhe, Xu Fang, Liu Li, Luo Qiong, Shen Yan, Wu Xingxin, Wu Xuefeng, Sun Yang, Wu Xudong*, Xu Qiang*. Biochemical Pharmacology. 2018 Jul; 153:269-281. doi: 10.1016/j.bcp.2018.01.033.

10. Fatty liver diseases, mechanisms, and potential therapeutic plant medicines. ZHU Jia-Zhen, YI Hong-Wei, HUANG Wei, PANG Tao, ZHOU Hui-Ping*, WU Xu-Dong*. Chinese Journal of Nature Medicines. 2020 March; 18(3): 161–168. doi:10.1016/S1875-5364(20)30017-0. 


团队风采