副教授,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:yjzhang@nju.edu.cn
研究领域 |
分泌miRNA的功能与应用
工作经历 |
2011-2016,南京大学生命科学学院,助理研究员
2016至今,南京大学生命科学学院,副教授
学术任职 |
2022-,《Frontiers In Immunology》(IF:8.9) 客作编辑
代表性成果 |
[1] Jing Li#, Yujing Zhang#, Yangyang Ye#, Dameng Li#, Yuchen Liu, Eunyoung Lee, Mingliang Zhang, Xin Dai, Xiang Zhang, ShibeiWang, Junfeng Zhang, Weiping Jia, Ke Zen*, Antonio Vidal-Puig*, Xiaohong Jiang*, Chen-Yu Zhang*, Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR-29 family. J Extracell Vesicles, 2021 Jan;10(3):e12055.
原文链接:https://pubmed.ncbi.nlm.nih.gov/33520119/
[2] Dameng Li#, Huichen Song1#, Linghu Shuo, Lei Wang, Ping Xie, Weili Li, Jiachen Liu, Yafei Tong, Chen-Yu Zhang, Xiaohong Jiang*, Jing Li*, Yujing Zhang*,Gonadal white adipose tissue-derived exosomal MiR-222 promotes obesity-associated insulin resistance. Aging-US, 2020 Nov 10;12(22):22719-22743
原文链接:https://pubmed.ncbi.nlm.nih.gov/33197889/
[3] Zheng S, Guo S, Sun G, Shi Y, Wei Z, Tang Y, He F, Shi C, Dai P, Chong H, Samuelson I, Zen K, Zhang CY, Zhang Y*, Li J*, Jiang X*. Gain of Metabolic Benefit with Ablation of miR-149-3p from Subcutaneous Adipose Tissue in Diet-Induced Obese Mice. Mol Ther Nucleic Acids. 2019 Aug 26;18:194-203.
原文链接:https://pubmed.ncbi.nlm.nih.gov/31561124/
[4] Zhang A#, Li D#, Liu Y, Li J, Zhang Y*, Zhang CY*, Islet β cell: An endocrine cell secreting miRNAs, Biochem Biophys Res Commun. 2018 Jan 8;495(2):1648-1654
原文链接:https://pubmed.ncbi.nlm.nih.gov/29223394/
[5] Liu Y, Li D, Liu Z, Zhou Y, Chu D, Li X, Jiang X, Hou D, Chen X, Chen Y, Yang Z, Jin L, Jiang W, Tian C, Zhou G,Zen K, Zhang J, Zhang Y*, Li J*, Zhang CY*. Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse. Sci Rep. 2015 Dec 3;5:17543. doi: 10.1038/srep17543
原文链接:https://pubmed.ncbi.nlm.nih.gov/26633001/
[6] Li J+, Zhang Y+, Li D, Liu Y, Chu D, Jiang X, Hou D, Zen K, Zhang CY. Small noncoding RNAs transfer through mammalian placenta and directly regulate fetal gene expression. Protein Cell. 2015 Jun;6(6):391-6. Doi:10.1007/s13238-015-0156-2.
原文链接:https://pubmed.ncbi.nlm.nih.gov/25963995/
[7] Zhang J, Li L, Li J, Liu Y, Zhang CY*, Zhang Y*, Zen K*. Protein tyrosine phosphatase 1B impairs diabetic wound healing through vascular endothelial growth factor receptor 2 dephosphorylation. (2015) Arterioscler Thromb Vasc Biol.Jan;35(1):163-74.
原文链接:https://pubmed.ncbi.nlm.nih.gov/25395617/
[8] Liu Y, Zhao L, Li D, Yin Y, Zhang CY*, Li J*, Zhang Y*. Microvesicle-delivery miR-150 promotes tumorigenesis by up-regulating VEGF, and the neutralization of miR-150 attenuate tumor development. (2013) Protein & Cell. 4(12):932-941.
原文链接:https://pubmed.ncbi.nlm.nih.gov/24203759/
[9] Li J+, Zhang Y+, Liu Y, Dai X, Li W, Cai X, Yin Y, Wang Q, Xue Y, Wang C, Li D, Hou D, Jiang X, Zhang J, Zen K*, Chen X*, Zhang CY*. Microvesicle-mediated transfer of miR-150 from monocytes to endothelial cells promotes angiogenesis. (2013) The Journal of Biological Chemistry. 2013 Aug 9;288(32):23586-96.
原文链接:https://pubmed.ncbi.nlm.nih.gov/23766514/
[10] Zhang Y+, Liu D+, Chen X+, Li J, Li L, Bian Z, Sun F, Lu J, Yin Y, Cai X, Sun Q, Wang K, Ba Y, Wang Q, Wang D, Yang J, Liu P, Xu T, Yan Q, Zhang J*, Zen K*, Zhang CY*. Secreted monocytic miR-150 enhances targeted endothelial cell migration. (2010) Mol Cell 39(1): 133-144.
原文链接:https://pubmed.ncbi.nlm.nih.gov/20603081/
团队风采 |