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  • 张玉婧

副教授,医药生物技术国家重点实验室 

地址:南京市栖霞区仙林大道163号,210023

邮箱:yjzhang@nju.edu.cn









研究领域


分泌miRNA的功能与应用



工作经历


2011-2016,南京大学生命科学学院,助理研究员

2016至今,南京大学生命科学学院,副教授



学术任职


2022-,《Frontiers In Immunology(IF:8.9) 客作编辑




代表性成果

[1] Jing Li#, Yujing Zhang#, Yangyang Ye#, Dameng Li#, Yuchen Liu, Eunyoung Lee, Mingliang Zhang, Xin Dai, Xiang Zhang, ShibeiWang, Junfeng Zhang, Weiping Jia, Ke Zen*, Antonio Vidal-Puig*, Xiaohong Jiang*,  Chen-Yu Zhang*, Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR-29 family. J Extracell Vesicles, 2021 Jan;10(3):e12055.

原文链接:https://pubmed.ncbi.nlm.nih.gov/33520119/

[2] Dameng Li#, Huichen Song1#, Linghu Shuo, Lei Wang, Ping Xie, Weili Li, Jiachen Liu, Yafei Tong, Chen-Yu Zhang, Xiaohong Jiang*, Jing Li*, Yujing Zhang*Gonadal white adipose tissue-derived exosomal MiR-222 promotes obesity-associated insulin resistance. Aging-US, 2020 Nov 10;12(22):22719-22743

原文链接:https://pubmed.ncbi.nlm.nih.gov/33197889/ 

[3] Zheng S, Guo S, Sun G, Shi Y, Wei Z, Tang Y, He F, Shi C, Dai P, Chong H, Samuelson I, Zen K, Zhang CY, Zhang Y*, Li J*, Jiang X*. Gain of Metabolic Benefit with Ablation of miR-149-3p from Subcutaneous Adipose Tissue in Diet-Induced Obese Mice. Mol Ther Nucleic Acids. 2019 Aug 26;18:194-203.

原文链接:https://pubmed.ncbi.nlm.nih.gov/31561124/ 

[4] Zhang A#, Li D#, Liu YLi JZhang Y*, Zhang CY*, Islet β cell: An endocrine cell secreting miRNAs, Biochem Biophys Res Commun. 2018 Jan 8;495(2):1648-1654

原文链接:https://pubmed.ncbi.nlm.nih.gov/29223394/

[5] Liu YLi DLiu ZZhou YChu DLi XJiang XHou DChen XChen YYang ZJin LJiang WTian CZhou G,Zen KZhang JZhang Y*Li J*, Zhang CY*. Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse. Sci Rep. 2015 Dec 3;5:17543. doi: 10.1038/srep17543

原文链接:https://pubmed.ncbi.nlm.nih.gov/26633001/ 

[6] Li J+Zhang Y+, Li D, Liu Y, Chu D, Jiang X, Hou D, Zen K, Zhang CY. Small noncoding RNAs transfer through mammalian placenta and directly regulate fetal gene expression. Protein Cell. 2015 Jun;6(6):391-6. Doi:10.1007/s13238-015-0156-2.

原文链接:https://pubmed.ncbi.nlm.nih.gov/25963995/ 

[7] Zhang J, Li L, Li J, Liu Y, Zhang CY*, Zhang Y*, Zen K*. Protein tyrosine phosphatase 1B impairs diabetic wound healing through vascular endothelial growth factor receptor 2 dephosphorylation. (2015) Arterioscler Thromb Vasc Biol.Jan;35(1):163-74.

原文链接:https://pubmed.ncbi.nlm.nih.gov/25395617/ 

[8] Liu Y, Zhao L, Li D, Yin Y, Zhang CY*, Li J*, Zhang Y*. Microvesicle-delivery miR-150 promotes tumorigenesis by up-regulating VEGF, and the neutralization of miR-150 attenuate tumor development. (2013) Protein & Cell. 4(12):932-941. 

原文链接:https://pubmed.ncbi.nlm.nih.gov/24203759/ 

[9] Li J+, Zhang Y+, Liu Y, Dai X, Li W, Cai X, Yin Y, Wang Q, Xue Y, Wang C, Li D, Hou D, Jiang X, Zhang J, Zen K*, Chen X*, Zhang CY*. Microvesicle-mediated transfer of miR-150 from monocytes to endothelial cells promotes angiogenesis. (2013) The Journal of Biological Chemistry. 2013 Aug 9;288(32):23586-96. 

原文链接:https://pubmed.ncbi.nlm.nih.gov/23766514/

[10] Zhang Y+, Liu D+, Chen X+, Li J, Li L, Bian Z, Sun F, Lu J, Yin Y, Cai X, Sun Q, Wang K, Ba Y, Wang Q, Wang D, Yang J, Liu P, Xu T, Yan Q, Zhang J*, Zen K*, Zhang CY*. Secreted monocytic miR-150 enhances targeted endothelial cell migration. (2010) Mol Cell 39(1): 133-144. 

原文链接:https://pubmed.ncbi.nlm.nih.gov/20603081/


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