- 吴雪丰
副教授、博导，医药生物技术国家重点实验室
地址：南京市仙林校区仙林大道163号，210023
邮箱：wuxf@nju.edu.cn
| 研究领域 |
免疫病理和免疫药理
| 工作经历 |
2022-，南京大学博士生导师
2005-，南京大学生命科学学院讲师，副教授
2009-2010，美国，Parker University，Research Associate
| 荣誉奖励 |
2018，教育部自然科学一等奖（排名第四）
2007-，南京大学中国银行奖教奖，创新育人奖教奖，魅力导师奖。
| 学术任职 |
2006-，中国药理学会会员，中国免疫学会会员
| 代表性成果 |
1. Wu XX, Wu XD, Ma Y, Shao F, Tan Y, Tan T, Gu L, Zhou Y, Sun B, Sun Y, Wu XF*, Xu Q. CUG-binding protein 1 regulates HSC activation and liver fibrogenesis. Nature Communication 2016; 7: 13498.
2. Wang J, Bai M, Zhang C, An N, Wan L, Wang XN, Du RH, Shen Y, Yuan ZY, Wu XD, Wu XF*, Xu Q. Natural compound fraxinellone ameliorates intestinal fibrosis in mice via direct intervention of HSP47-collagen interaction in the epithelium. Acta Pharmacol Sin. 2023; 44(12):2469-2478.
3. Lin T, Hu L, Hu F, Li K, Wang C, Zong L, Zhao Y, Zhang X, Li Y, Yang Y, Wang Y, Jiang C, Wu XF*, Liu W. NETs-Triggered NLRP3 Activation and IL18 Release Drive Oxaliplatin-Induced Peripheral Neuropathy. Cancer Immunol Res. 2022 Dec 2;10(12):1542-1558.
4. Wang J, Shi K, An N, Li S, Bai M, Wu XD, Shen Y, Du RD, Cheng JC, Wu XF*，Xu Q. Direct Inhibition of GSDMD by PEITC Reduces Hepatocyte Pyroptosis and Alleviates Acute Liver Injury in Mice. Front. Immunol.2022, 13:825428.
5. Wang J, Shi K, Li S, Chen L, Liu W, Wu X, Shen Y, Sun Y, Cheng J, Wu XF*, Xu Q. Meisoindigo attenuates dextran sulfate sodium-induced experimental colitis via its inhibition of TAK1 in macrophages. Int Immunopharmacol. 2021 Dec;101(Pt B):108239.
6. Chen L, Wang J, You Q, He S, Meng Q, Gao J, Wu X, Shen Y, Sun Y, Wu XF*, Xu Q. Activating AMPK to Restore Tight Junction Assembly in Intestinal Epithelium and to Attenuate Experimental Colitis by Metformin. Front Pharmacol. 2018 Jul 16;9:761.
7. Chen L, You Q, Hu L, Gao J, Meng QQ, Liu WT, Wu XF*, Xu Q. The antioxidant procyanidin reduces reactive oxygen species signaling in macrophages and ameliorates experimental colitis in Mice. Front. Immunol. 2018, 8:1910.
8. Ouyang ZJ, Wang XQ, Meng QQ, Feng LL, Sun Y, Wu XF*, Xu Q. Suppression of adenosine monophosphate-activated protein kinase selectively triggers apoptosis in activated T cells and ameliorates immune diseases. Biochem Biophys Res Commun. 2017;487(2):223-229.
9. Ouyang ZJ, Li WS, Meng QQ, Zhang Q, Wang XQ, Elgehama A, Wu XD, Shen Y, Sun Y, Wu XF*, Xu Q. A natural compound jaceosidin ameliorates endoplasmic reticulum stress and insulin resistance via upregulation of SERCA2b. Biomed Pharmacother. 2017;89:1286-1296.
10. Wang X, Wu XF*, Zhang A, Wang S, Hu C, Chen W, Shen Y, Tan R, Sun Y, Q Xu. Targeting the PDGF-B/PDGFR-β interface with destruxin A5 to selectively block PDGF-BB/PDGFR-ββ signaling and attenuate liver fibrosis. EBioMedicine 2016, 7: 146-156. doi: 10.1016/j.ebiom.2016.03.042.
