研究员、教授,医药生物技术国家重点实验室
地址:南京市仙林校区仙林大道163号,210023
邮箱:yanguijun@nju.edu.cn
研究领域 |
胚胎植入调控
工作经历 |
2008-2015,南京鼓楼医院生殖医学科副研究员
2015 -,南京大学博士生导师
2016-,南京鼓楼医院生殖医学科研究员
2018-,南京大学教授
荣誉奖励 |
2011,江苏省“科教兴卫工程”医学重点人才
2016,江苏省“科教强卫工程”医学重点人才
2016,提高IVF患者子宫内膜容受性的基础与临床研究。江苏医学科技二等奖
2018,干细胞复合胶原支架引导子宫内膜重建治疗重度宫腔粘连的基础与临床研究。江苏省科学技术一等奖
2023,辅助生殖技术精准个体化胚胎移植策略的建立及临床应用。江苏医学科技二等奖
学术任职 |
2016-,中国微生物学会科技开发与咨询委员会委员
2017-,江苏省发育生物学学会生殖专业委员会常务委员
代表性成果 |
[1] X. Cai, Y. Jiang, Z. Cao, M. Zhang, N. Kong, L. Yu, Y. Tang, S. Kong, W. Deng, H. Wang, J. Sun, L. Ding, R. Jiang*, H. Sun*, G .Yan*. Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice. EBioMedicine 2023, 88,104433-104450.
原文链接:https://www.sciencedirect.com/science/article/pii/S2352396422006156?via%3Dihub
[2] H. Wang, Y. Liu, D. Li, J. Liu, Y. Jiang, Y. He, J. Zhou, Z. Wang, X. Tang, Y. Zhang, X. Zhen, Z. Cao, X. Sheng, C. Yang, Q. Yue, L. Ding, Y. Hu, Z. Hu, C. Li*, G. Yan*, H. Sun*. Maternal and embryonic signals cause functional differentiation of luminal epithelial cells and receptivity establishment. Dev Cell 2023, 58, 2376-2392.
原文链接:https://www.sciencedirect.com/science/article/abs/pii/S1534580723004008?via%3Dihub
[3] Z. Wang, Y. Liu, J. Liu, N. Kong, Y. Jiang, R. Jiang, X. Zhen, J. Zhou, C. Li, H. Sun*, G. Yan*, ATF3 deficiency impairs the proliferative-secretory phase transition and decidualization in RIF patients. Cell Death Dis 2021, 12, 387-402.
原文链接:https://www.nature.com/articles/s41419-021-03679-8
[4] Q. Zhou, G. Yan, L. Ding, J. Liu, X. Yu, S. Kong, M. Zhang, Z. Wang, Y. Liu, Y. Jiang, N. Kong, J. Sun*, H. Sun*. EHD1 impairs decidualization by regulating the Wnt4/β-catenin signaling pathway in recurrent implantation failure. EBioMedicine 2019, 50, 343-354.
原文链接:https://europepmc.org/article/pmc/6921214
[5] Q. Yan, C. Huang, Y. Jiang, H. Shan, R. Jiang, J. Wang, J. Liu, L. Ding, G. Yan*, H. Sun*, Calpain7 impairs embryo implantation by downregulating β3-integrin expression via degradation of HOXA10. Cell Death Dis 2018, 9, 291-302.
原文链接:https://www.nature.com/articles/s41419-018-0317-3
[6] M. Zhang, Q. Zhang, Y. Hu, L. Xu, Y. Jiang, C. Zhang, L. Ding, R. Jiang, J. Sun, H. Sun*, G. Yan*, miR-181a increases FoxO1 acetylation and promotes granulosa cell apoptosis via SIRT1 downregulation. Cell Death Dis 2017, 8, 467-476.
原文链接:https://www.nature.com/articles/cddis2017467
[7] H.X. Sun, D.Y. Zeng, R.T. Li, R.P. Pang, H. Yang, Y.L. Hu, Q. Zhang, Y. Jiang, L.Y. Huang, Y.B. Tang, G.J. Yan*, J.G. Zhou*, Essential role of microRNA-155 in regulating endothelium-dependent vasorelaxation by targeting endothelial nitric oxide synthase. Hypertension 2012, 60, 1407-1414.
原文链接:https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.112.
197301
[8] G. Yan, B. You, S.P. Chen, J.K. Liao*, J. Sun*, Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1. Circ Res 2008, 103, 591-597.
原文链接:https://europepmc.org/article/MED/18688046
[9] A. Ren, G. Yan, B. You, J. Sun*, Down-regulation of mammalian sterile 20-like kinase 1 by heat shock protein 70 mediates cisplatin resistance in prostate cancer cells. Cancer Res 2008, 68, 2266-2274.
原文链接:https://aacrjournals.org/cancerres/article/68/7/2266/540684/Down-regulation-of-Mammalian-Sterile-20-Like
[10] G. Yan, S. Chen, B. You, J. Sun*, Activation of sphingosine kinase-1 mediates induction of endothelial cell proliferation and angiogenesis by epoxyeicosatrienoic acids. Cardiovasc Res 2008, 78, 308-314.
原文链接:https://academic.oup.com/cardiovascres/article/78/2/308/351233
团队风采 |