教授,主任技师,博士生导师,医药生物技术国家重点实验室
地址:南京市中山东路305号东部战区总医院肾脏病大楼1804室,邮编210002
邮箱:shaolin.shi@nju.edu.cn
研究领域 |
肾小球分子病理和治疗靶点
工作经历 |
1997-1998 英国Glasgow大学/Cyclacel公司博士后
1998-2004 美国Albert Einstein医学院博士后
2005-2011 美国Mount Sinai Icahn医学院助理教授
2011- 东部战区总医院国家肾脏病医学临床研究中心主任技师
2018 - 南京大学医学院教授
荣誉奖励 |
2011,江苏省“双创”人才计划
2017,江苏省科技进步一等奖(4/10)
2020,国家科技进步二等奖(5/10)
2023,江苏医学科技奖二等奖(7/7)
学术任职 |
2022- Frontiers Physiol Renal Physiol副主编
代表性成果 |
1. Tang Q, Shi W, Liu M, Tang L*, Ren W*, Shi S*. Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis. Clin Sci (Lond). 2023 Aug 14;137(15):1195-1208.
2. Zhang S, Wu J, Zhu X, Song H, Ren L, Tang Q, Xu X, Liu C, Zhang J, Hu W, Liu Z*, Shi S*. A novel approach to identify the mechanism of miR-145-5p toxicity to podocytes based on the essential genes targeting analysis. Mol Ther Nucleic Acids. 2021; 26:749-759.
3. Lang Y, Zhao Y, Zheng C, Lu Y, Wu J, Zhu X, Zhang M, Yang F, Xu X, Shi S*, Liu Z*. MiR-30 family prevents uPAR-ITGB3 signaling activation through calcineurin-NFATC pathway to protect podocytes. Cell Death Dis. 2019; 10:401.
4. Lu Y, Ye Y, Bao W, Yang Q, Wang J, Liu Z, Shi S*. Genome-wide identification of genes essential for podocyte cytoskeletons based on single-cell RNA sequencing. Kidney Int. 2017; 92: 1119-1129.
5. Lu Y, Ye Y, Yang Q, Shi S*. Single-cell RNA-sequence analysis of mouse glomerular mesangial cells uncovers mesangial cell essential genes. Kidney Int. 2017; 92:504-513.
6. Bao W, Xia H, Liang Y, Ye Y, Lu Y, Xu X, Duan A, He J, Chen Z, Wu Y, Wang X, Zheng C, Liu Z, Shi S*. Toll-like Receptor 9 Can be Activated by Endogenous Mitochondrial DNA to Induce Podocyte Apoptosis. Sci Rep. 2016, 6:22579.
7. Wu J, Zheng C, Wang X, Yun S, Zhao Y, Liu L, Lu Y, Ye Y, Zhu X, Zhang C, Shi S*, Liu Z*. MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes. J Clin Invest. 2015, 125:4091-4106.
8. Zhang C, Zhang W, Chen H, Liu C, Wu J, Shi S*, Liu Z*. Plasma microRNA-186 and proteinuria in focal segmental glomerulosclerosis. Am J Kidney Dis. 2015; 65:223-32.
9. Shi S*, Yu L, Chiu C, Sun Y, Chen J, Khitrov G, Merkenschlager M, Holzman LB, Zhang W, Mundel P, Bottinger EP. Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. J Am Soc Nephrol. 2008; 19:2159-69.
10. Shi S, Stanley P. Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways. Proc Natl Acad Sci U S A. 2003; 100:5234-5239.
团队风采 |