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  • 施少林

教授,主任技师,博士生导师,医药生物技术国家重点实验室 

地址:南京市中山东路305号东部战区总医院肾脏病大楼1804室,邮编210002

邮箱:shaolin.shi@nju.edu.cn









研究领域


肾小球分子病理和治疗靶点



工作经历


1997-1998  英国Glasgow大学/Cyclacel公司博士后

1998-2004  美国Albert Einstein医学院博士后

2005-2011  美国Mount Sinai Icahn医学院助理教授

2011-      东部战区总医院国家肾脏病医学临床研究中心主任技师

2018 -     南京大学医学院教授


荣誉奖励


2011,江苏省“双创”人才计划

2017,江苏省科技进步一等奖(4/10

2020,国家科技进步二等奖(5/10

2023江苏医学科技奖二等奖(7/7)



学术任职


2022-   Frontiers Physiol Renal Physiol副主编




代表性成果

1. Tang Q, Shi W, Liu M, Tang L*, Ren W*, Shi S*. Mitochondrial protein MPV17 promotes β-cell apoptosis in diabetogenesis. Clin Sci (Lond). 2023 Aug 14;137(15):1195-1208. 

2. Zhang S, Wu J, Zhu X, Song H, Ren L, Tang Q, Xu X, Liu C, Zhang J, Hu W, Liu Z*, Shi S*. A novel approach to identify the mechanism of miR-145-5p toxicity to podocytes based on the essential genes targeting analysis. Mol Ther Nucleic Acids. 2021; 26:749-759.

3. Lang Y, Zhao Y, Zheng C, Lu Y, Wu J, Zhu X, Zhang M, Yang F, Xu X, Shi S*, Liu Z*. MiR-30 family prevents uPAR-ITGB3 signaling activation through calcineurin-NFATC pathway to protect podocytes. Cell Death Dis. 2019; 10:401. 

4. Lu Y, Ye Y, Bao W, Yang Q, Wang J, Liu Z, Shi S*. Genome-wide identification of genes essential for podocyte cytoskeletons based on single-cell RNA sequencing. Kidney Int. 2017; 92: 1119-1129.

5. Lu Y, Ye Y, Yang Q, Shi S*. Single-cell RNA-sequence analysis of mouse glomerular mesangial cells uncovers mesangial cell essential genes. Kidney Int. 2017; 92:504-513. 

6. Bao W, Xia H, Liang Y, Ye Y, Lu Y, Xu X, Duan A, He J, Chen Z, Wu Y, Wang X, Zheng C, Liu Z, Shi S*. Toll-like Receptor 9 Can be Activated by Endogenous Mitochondrial DNA to Induce Podocyte Apoptosis. Sci Rep. 2016, 6:22579. 

7. Wu J, Zheng C, Wang X, Yun S, Zhao Y, Liu L, Lu Y, Ye Y, Zhu X, Zhang C, Shi S*, Liu Z*. MicroRNA-30 family members regulate calcium/calcineurin signaling in podocytes. J Clin Invest. 2015, 125:4091-4106. 

8. Zhang C, Zhang W, Chen H, Liu C, Wu J, Shi S*, Liu Z*. Plasma microRNA-186 and proteinuria in focal segmental glomerulosclerosis. Am J Kidney Dis. 2015; 65:223-32. 

9. Shi S*, Yu L, Chiu C, Sun Y, Chen J, Khitrov G, Merkenschlager M, Holzman LB, Zhang W, Mundel P, Bottinger EP. Podocyte-selective deletion of dicer induces proteinuria and glomerulosclerosis. J Am Soc Nephrol. 2008; 19:2159-69.

10. Shi S, Stanley P. Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways. Proc Natl Acad Sci U S A. 2003; 100:5234-5239.


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