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  • 张骑鹏

副教授,医药生物技术国家重点实验室 

地址:南京市栖霞区仙林大道163号,210023

邮箱:qpzhang@nju.edu.cn









研究领域


本能行为动机的下丘脑神经环路机制

神经发育障碍疾病的神经病理学机制



工作经历


2014-,南京大学 硕士生导师

2013-,南京大学生命科学学院 副教授

2009-2013,南京大学生命科学学院 讲师



荣誉奖励


2019,南京大学 仲英青年学者



代表性成果

[1] Chen Q, Zhang F, Dong L, Wu H, Xu J, Li H, Wang J, Zhou Z, Liu C, Wang Y, Liu Y, Lu L, Wang C, Liu M, Chen X, Wang C, Zhang C, Li D, Zen K, Wang F*, Zhang Q*, Zhang CY*. SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs. Cell research202131(3), 247-258.

原文链接:https://www.nature.com/articles/s41422-020-0389-3

[2] Peng Wang, Yanchufei Zhang, Zihui Wang, Anyong Yang, Yuting Li, Qipeng Zhang. miR-128 regulates epilepsy sensitivity in mice by suppressing SNAP-25 and SYT1 expression in the hippocampus. Biochem Biophys Res Commun2021545, 195-202.

原文链接:https://doi.org/10.1016/j.bbrc.2021.01.079

[3] Lu L, Zhang F, Li Y, Yang A, Guan C, Ding X, Liu Y, Liu Y, Zhang CY, Li L, Zhang Q. Dendritic targeted mRNA expression via a cis-acting RNA UTR element.

Biochem Biophys Res Commun2019509(2), 402-406.

原文链接: https://www.sciencedirect.com/science/article/pii/S0006291X1832802X?via%3Dihub

[4] Pan, F., Zhang, J., Liu, Y., Lu, L., Qiu, X., Lv, K., Zhang, Q. Intracavernosal Pressure Recording to Evaluate Erectile Function in Rodents. J Vis Exp2018, (136), 56798.

原文链接:https://www.jove.com/vedio/56798

[5] Zhang Q P, Sun A Y. Strategy for applying CRISPR/Cas9 gene editing technology in neuroscience (in Chinese). Chin Sci Bull201762, 3583–3593.

原文链接:https://www.sciengine.com/CSB/doi/10.1360/N972017-00670

[6] Pan F, You J, Liu Y, Qiu X, Yu W, Ma J, Pan L, Zhang A, Zhang Q. Differentially expressed microRNAs in the corpus cavernosum from a murine model with type 2 diabetes mellitus-associated erectile dysfunction. Mol Genet Genomics.2016291(6), 2215-2224.

原文链接:https://link.springer.com/article/10.1007/s00438-016-1250-8

[7] Chen Q, Xu J, Li L, Li H, Mao S, Zhang F, Zen K, Zhang CY, Zhang Q. MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis. Cell Death Dis20145, e1132.

原文链接:https://www.nature.com/articles/cddis201492

[8] Shi L#, Zhang Q#, Xu B, Jiang X, Dai Y, Zhang CY, Zen K. Sustained high protein-tyrosine phosphatase 1B activity in the sperm of obese males impairs the sperm acrosome reaction. J Biol Chem2014289(12), 8432-41.

原文链接:https://www.jbc.org/article/S0021-9258(20)52341-7/fulltext

[9] Xu J, Chen Q, Zen K, Zhang C, Zhang Q. Synaptosomes secrete and uptake functionally active microRNAs via exocytosis and endocytosis pathways. J Neurochem2013124(1), 15-25.

原文链接:https://onlinelibrary.wiley.com/doi/full/10.1111/jnc.12057

[10] Zhang Q, Zhang X, Sun A. Truncated tau at D421 is associated with neurodegeneration and tangle formation in the brain of Alzheimer transgenic models. Acta Neuropathol2009117(6), 687-97.

原文链接:https://link.springer.com/article/10.1007/s00401-009-0491-6