教授、博士生导师,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:wujunhua@nju.edu.cn
研究领域 |
1.肿瘤免疫治疗(尤其是溶瘤病毒和其他微生物介导的肿瘤免疫治疗)
2.肿瘤发生、发展的机制与治疗方法研究
3.化合物或者天然产物活性与功能的发现、评价与作用机制研究
工作经历 |
2007-2014 南京大学医学院 讲师
2014-2019 南京大学医学院 副教授
2019- 南京大学医学院 教授
学术任职 |
2021-,Translational Oncology刊物编委
2022- Biocell刊物编委
2022- Discovery Medicine刊物编委
代表性成果 |
1. Wu JH#, Li PF#, Dong CL#, Jiang HT, Bin Xue, Gao X, Qin M, Wang W*, Bin Chen*, Cao Y*. Rationally designed synthetic protein hydrogels with predictable mechanical properties. Nature Communications. 2018, 9(1): 620. Doi: 10.1038/s41467-018-02917-6. IF: 17.694
2. Ciliang Guo, Lingkai Kong, Lingjun Xiao, Kua Liu, Huawei Cui, Qilei Xin, Xiaosong Gu, Chunping Jiang*, Junhua Wu*. The impact of the gut microbiome on tumor immunotherapy: from mechanism to application strategies. Cell and Bioscience, 2023 Oct 13;13(1):188. DOI: 10.1186/s13578-023-01135-y *通讯作者
3. Yan Zhuang, Kua Liu, Qinyu He, Xiaosong Gu, Chunping Jiang*, Junhua Wu*. Hypoxia signaling in cancer: Implications for therapeutic interventions. MedComm, 2023 Jan 23;4(1):e203. DOI: 10.1002/mco2.203 *通讯作者
4. Mao Xia#, Dongjun Luo#, Jie Dong#, Meihong Zheng, Gang Meng, Junhua Wu* and Jiwu Wei*. Graphene oxide arms oncolytic measles virus for improved effectiveness of cancer therapy. Journal of Experimental & Clinical Cancer Research (2019) 38: 408. IF: 12.658 *通讯作者
5. Zhen Qu#, Junhua Wu#, Junyi Wu, Dongjun Luo, Chunping Jiang* and Yitao Ding*. Exosomes derived from HCC cells induce sorafenib resistance in hepatocellular carcinoma both in vivo and in vitro. Journal of Experimental & Clinical Cancer Research (2016) 35:159. #Co-first author IF: 12.658
6. Hailin Zhang, Yonghui Zhang, Jie Dong, Shuguang Zuo, Gang Meng, Junhua Wu⁎, Jiwu Wei⁎. Recombinant adenovirus expressing the fusion protein PD1PVR improves CD8+ T cell‑mediated antitumor efficacy with long‑term tumor‑specific immune surveillance in hepatocellular carcinoma. Cellular Oncology,2021, 1243-1255 IF: 7.051 *通讯作者
7. Chun Xu#, Xian Lu#, Wei Liu, Anxian Chen, Gang Meng, Hailin Zhang, Binghua Li, Yonghui Zhang, Junhua Wu*,Jiwu Wei*. CD8+ T cells mediate the antitumor activity of frankincense and myrrh in hepatocellular carcinoma. Journal of Translational Medicine, 2018, 16: 132. IF: 8.44 *通讯作者
8. Junhua Wu, Aiping Chen, Meng Qin, Rong Huang, Guang Zhang, Bin Xue, Xiang Gao, Ying Li, Yi Cao and Wei Wang. Hierarchical construction of a mechanically stable peptide-graphene oxide hybrid hydrogel for drug delivery and pulsatile triggered release in vivo. Nanoscale 2015 (7), 1655 DOI: 10.1039/C4NR05798H. IF: 8.307 肝癌治疗新方法,该文章2016年被列为Web of Science高被引文章(学科前1%)
9. Lu X#, Wo G#, Li B, Xu C, Wu J*, Jiang C*, Wei J*. The anti-inflammatory NHE-06 restores antitumor immunity by targeting NF-κB/IL-6/STAT3 signaling in hepatocellular carcinoma. Biomedicine & Pharmacotherapy, 2018, 102: 420-427. IF: 7.419
10. Hailin Zhang, Yonghui Zhang, Jie Dong, Chun Xu, Min Wei, Junhua Wu* and Jiwu Wei*. Recombinant oncolytic adenovirus expressing a soluble PVR elicits long-term antitumor immune surveillance. Molecular Therapy: Oncolytics Volume 20, 26 March 2021, Pages 12-22 IF: 6.311 *通讯作者
团队风采 |