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  • 张博

副教授,医药生物技术国家重点实验室 

地址:南京市栖霞区仙林大道163号,210023

邮箱:bzhang@nju.edu.cn









研究领域


天然产物生物合成;结构生物学与酶化学



工作经历


2013-2015,美国斯克里普斯研究所,联合培养博士

2016-2018,南京大学生命科学学院,博士后

2018-2019,南京大学生命科学学院,助理研究员

2020- 南京大学生命科学学院,副教授



荣誉奖励


2021,万人计划“青年拔尖人才”

2022,江苏省基金委“优秀青年”基金



代表性成果

[1] H. J. Zhu#, B. Zhang#, W. Wei#, S. H. Liu, L. Xiang, J. Zhu, R. H. Jiao, Y. Igarashi, G. Bashiri, Y. Liang*, R. X. Tan*, H. M. Ge*. AvmM catalyses macrocyclization through dehydration/Michael-type addition in alchivemycin A biosynthesis. Nat. Commun. 202213, 4499.

[2] S. H. Liu, J. L. Sun, Y. L. Hu, L. Zhang, X. Zhang, Z. Y. Yan, X. Guo, Z. K. Guo, R. H. Jiao, B. Zhang*, R. X. Tan*, H. M. Ge*, Biosynthesis of Sordarin Revealing a Diels–Alderase for the Formation of the Norbornene Skeleton. Angew. Chem. Int. Ed. Engl. 202261, e202205577.

[3] H. J. Zhu, B. Zhang, L. Wang, W. Wang, S. H. Liu, Y. Igarashi, G. Bashiri, R. X. Tan*, H. M. Ge*, Redox Modifications in the Biosynthesis of Alchivemycin A Enable the Formation of Its Key Pharmacophore. J. Am. Chem. Soc.2021143, 4751-4757.

[4] K. B. Wang#, W. Wang#, B. Zhang#, X. Wang, Y. Chen, H. J. Zhu, Y. Liang, R*. X. Tan*, H. M. Ge*, A[6+4]-cycloaddition adduct is the biosynthetic intermediate in streptoseomycin biosynthesis. Nat. Commun. 202112, 2092.

[5] S. H. Liu#, Y. Y. Wei#, Y. N. Xing, Y. Chen, W. Wang, K. B. Wang, Y. Liang, R. H. Jiao, B. Zhang*, H. M. Ge*, A BBE-like Oxidase, AsmF, dictates the formation of naphthalenic hydroxyl groups in ansaseomycin biosynthesis. Org. Lett. 202123, 3724-3728.

[6] C. L. Yang#, B. Zhang#, W. W. Xue, W. Li, Z. F. Xu, J. Shi, Y. Shen, R. H. Jiao, R. X. Tan, H. M. Ge*, Discovery, biosynthesis, and heterologous production of loonamycin, a potent anticancer indolocarbazole alkaloid. Org. Lett. 202022, 4665-4669.

[7] B. Zhang#, K. B. Wang#, W. Wang#, X. Wang#, F. Liu, J. Zhu, J. Shi, L. Y. Li, H. Han, K. Xu, H. Y. Qiao, X. Zhang, R. H. Jiao, K. N. Houk*, Y. Liang*, R. X. Tan*, H.-M. Ge*, Enzyme-catalysed [6+4] cycloadditions in the biosynthesis of natural products. Nature 2019568, 122-126.

[8] B. Zhang#, K. B. Wang#, W. Wang, S. F. Bi, Y. N. Mei, X. Z. Deng, R. H. Jiao, R. X. Tan*, H.-M. Ge*, Discovery, biosynthesis, and heterologous production of streptoseomycin, an anti-microaerophilic bacteria macrodilactone. Org. Lett.201820, 2967-2971.

[9] Y. S. Wang#, B. Zhang#, J. Zhu, C. L. Yang, Y. Guo, C. L. Liu, F. Liu, H. Huang, S. Zhao, Y. Liang, R. H. Jiao, R. X. Tan*, H.-M. Ge*, Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis. J. Am. Chem. Soc. 2018140, 10909-10914.

[10] B. Zhang#, Z. Xu#, Q. Teng#, G. Pan, M. Ma, B. Shen*, A long-range acting dehydratase domain as the missing link for C17-dehydration in iso-migrastatin biosynthesis. Angew. Chem. Int. Eng. 201756, 7247-7251.