副教授,博士生导师,南京大学医学院模式动物研究所实验动物中心主任,医药生物技术国家重点实验室 PI
地址:南京市浦口区学府路12号,210061
邮箱:linzy @nju.edu.cn
研究领域 |
生理稳态的免疫和代谢调控
工作经历 |
2012-2013年,南京大学化学化工学院博士后
2014-,南京大学副研究员
2019-,南京大学副教授
学术任职 |
中国细胞生物学学会细胞死亡研究分会理事
中国生物物理学会代谢生物学分会青年理事
中国江苏省动物学会理事
杂志任职 |
J Mol Cell Biol杂志编委
Front Endocrinol杂志编委
代表性成果 |
1. Li, X., T. Zhang, L. Kang, R. Xin, M. Sun, Q. Chen, J. Pei, Q. Chen, X. Gao*, and Z. Lin*, Apoptotic caspase-7 activation inhibits non-canonical pyroptosis by GSDMB cleavage. Cell Death Differ, 2023. 30(9): p. 2120-2134.
2. Zhao, M., K. Ren, X. Xiong, Y. Xin, Y. Zou, J.C. Maynard, A. Kim, A.P. Battist, N. Koneripalli, Y. Wang, Q. Chen, R. Xin, C. Yang, R. Huang, J. Yu, Z. Huang, Z. Zhang, H. Wang, D. Wang, Y. Xiao, O.C. Salgado, N.N. Jarjour, K.A. Hogquist, X.S. Revelo, A.L. Burlingame, X. Gao, J. von Moltke, Z. Lin*, and H.B. Ruan*, Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C. Immunity, 2022. 55(4): p. 623-638.e5.
3. Zou, Y., J. Pei, Y. Wang, Q. Chen, M. Sun, L. Kang, X. Zhang, L. Zhang, X. Gao*, and Z. Lin*, The Deficiency of SCARB2/LIMP-2 Impairs Metabolism via Disrupted mTORC1-Dependent Mitochondrial OXPHOS. Int J Mol Sci, 2022. 23(15).
4. Kang, L., J. Dai, Y. Wang, P. Shi, Y. Zou, J. Pei, Y. Tian, J. Zhang, V.C. Buranasudja, J. Chen*, H. Cai*, X. Gao*, and Z. Lin*, Blocking Caspase-1/Gsdmd and Caspase-3/-8/Gsdme pyroptotic pathways rescues silicosis in mice. PLoS Genet, 2022. 18(12): p. e1010515.
5. Chen, Q., J. Zheng, D. Wang, Q. Liu, L. Kang, X. Gao*, and Z. Lin*, Nitrosonisoldipine is a selective inhibitor of inflammatory caspases and protects against pyroptosis and related septic shock. Eur J Immunol, 2021. 51(5): p. 1234-1245.
6. Zou, D., J. Pei, J. Lan, H. Sang, H. Chen, H. Yuan, D. Wu, Y. Zhang, Y. Wang, D. Wang, Y. Zou, D. Chen, J. Ren*, X. Gao*, and Z. Lin*, A SNP of bacterial blc disturbs gut lysophospholipid homeostasis and induces inflammation through epithelial barrier disruption. EBioMedicine, 2020. 52: p. 102652.
7. Wang, D., J. Zheng, Q. Hu, C. Zhao, Q. Chen, P. Shi, Q. Chen, Y. Zou, D. Zou, Q. Liu, J. Pei, X. Wu, X. Gao*, J. Ren*, and Z. Lin*, Magnesium protects against sepsis by blocking gasdermin D N-terminal-induced pyroptosis. Cell Death Differ, 2020. 27(2): p. 466-481.
8. Sun, M., S. Zheng, X. Gao*, and Z. Lin*, The role of immune cells in obesogenic memory. Cell Mol Immunol, 2020.
9. Wang, Y., P. Shi, Q. Chen, Z. Huang, D. Zou, J. Zhang, X. Gao*, and Z. Lin*, Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation. J Mol Cell Biol, 2019. 11(12): p. 1069-1082.
10. Chen, Q., P. Shi, Y. Wang, D. Zou, X. Wu, D. Wang, Q. Hu, Y. Zou, Z. Huang, J. Ren*, Z. Lin*, and X. Gao*, GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity. J Mol Cell Biol, 2019. 11(6): p. 496-508.
团队风采 |