- 方雷
教授、博士生导师，医药生物技术国家重点实验室
地址：南京市鼓楼校区汉口路22号，210093
邮箱：njfanglei@nju.edu.cn
| 研究领域 |
蛋白质组学与大数据；代谢稳态调控与疾病发生
| 工作经历 |
2022.01-至今，南京大学医学院，教授
2021.06-至今，南京大学医学院，博士生导师
2019.09-至今，南京大学化学与生物医药创新研究院，双聘PI
2015.03-2022.01，南京大学医学院，副教授、硕士生导师
2011.10-2015.02，美国纽约大学Langone医学中心，助理研究员
2007.03-2011.09，美国加州大学Irvine分校，博士后研究员
| 荣誉奖励 |
1．方雷(4/6)，微生物基因工程可溶性表达及产物后加工新技术，中华人民共和国国务院，国家技术发明奖，二等奖，2013。
2．方雷(3/11)，微生物基因工程可溶性表达及产物后加工新技术，江苏省人民政府，江苏省科学技术奖，一等奖，2012。
| 学术任职 |
江苏省细胞与发育生物学会理事
江苏省高等学校医药教育研究会-医学人文素质教育专业委员会理事（第四届）
| 代表性成果 |
(1) Wen-Yuan Wu, Zi-Xuan Wang, Tu-Shuai Li, Xiao-Qin Ding, Zhi-Hong Liu, Jie Yang, Lei Fang*, Ling-Dong Kong*. SSBP1 drives high fructose-induced glomerular podocyte ferroptosis via activating DNA-PK/p53 pathway. Redox Biology. 2022 Jun;52:102303.
(2) Lei Fang# *, Tu-Shuai Li#, Jing-Zi Zhang#, Zhi-Hong Liu, Jie Yang, Bing-Hao Wang, Yu-Meng Wang, Jie Zhou, Ling-Dong Kong*. Fructose drives mitochondrial metabolic reprogramming in podocytes via Hmgcs2-stimulated fatty acid degradation. Signal Transduction and Targeted Therapy. 2021 Jul 9;6(1):253.
(3) Xiao Jiang, Xinyi Wang, Xianming Ding,MengjieDu, Boran Li, Xialian Weng, Jingzi Zhang, Lin Li, Rui Tian, Qi Zhu, She Chen, Liang Wang, Wei Liu, Lei Fang*, Dante Neculai*, Qiming Sun*. FAM134B oligomerization drives endoplasmic reticulum membrane scission for ER-phagy. EMBO J. 2020 Mar 2;39(5):e102608.
(4) Yue Zhao, Meng-Fei Zhao, Shan Jiang, Jing Wu, Jia Liu, Xian-Wen Yuan, Di Shen, Jing-Zi Zhang, Nan Zhou, Jian He, Lei Fang*, Xi-Tai Sun*, Bin Xue*, Chao-Jun Li*. Liver governs adipose remodelling via extracellular vesicles in response to lipid overload. Nature Communications. 2020 Feb 5;11(1):719.
(5) Wang B, Huang B, Li X, Guo Y, Qi G, Ding Y, Gao H, Zhang J, Wu X, Fang L. Development of functional anti-Gn nanobodies specific for SFTSV based on next generation sequencing and proteomics. Protein Sci. 2022 Sep 30:e4461. doi: 10.1002/pro.4461. Online ahead of print.
(6) Yan Guo , Qi Li, Wei Ren, Hongyan Wu, Chengzhi Wang, Xinyu Li, Bin Xue, Yudong Qiu, Jingzi Zhang, Jun Chen,Lei Fang. Quantitative Proteomics Reveals Down-Regulated Glycolysis/Gluconeogenesis in the Large-Duct Type Intrahepatic Cholangiocarcinoma. J Proteome Res. 2022 Oct 7;21(10):2504-2514. doi: 10.1021/acs.jproteome.2c00472.
(7) Zhao R, Wang B, Guo Y, Zhang J, Chen D, He WM, Zhao YJ, Ding Y, Jin C, Li C, Zhao Y, Ren W, Fang L.Quantitative Proteomics Reveals Arsenic Attenuates Stem-Loop Binding Protein Stability via a Chaperone Complex Containing Heat Shock Proteins and ERp44. Proteomics. 2021 Jun 16:e2100035.
(8) Lei Fang, Danqi Chen, Jingzi Zhang, Hongjie Li, Beatrix Bradford, Chunyuan Jin. Potential Functions of Histone H3.3 Lysine 56 Acetylation in Mammals. Epigenetics. 2021 May 24:1-20.
(9) Jingzi Zhang, Neng Tang, Yinjuan Zhao, Ruoyu Zhao, Xiao Fu, Dandan Zhao, Yue Zhao, Lan Huang, Chaojun Li, Yudong Qiu, Bin Xue, Lei Fang. Global Phosphoproteomic Analysis Reveals Significant Metabolic Reprogramming in the Termination of Liver Regeneration in Mice. J Proteome Res. 2020 Apr 3;19(4):1788-1799.
(10) Zhang J, Zhao R, Yu C, Bryant CLN, Wu K, Liu Z, Ding Y, Zhao Y, Xue B, Pan ZQ, Li C, Huang L, Fang L. IKK-mediated regulation of the COP9 signalosome via phosphorylation of CSN5. J Proteome Res. 2020 Mar 6;19(3):1119-1130.
| 团队风采 |
