副教授、博导,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:liangli@nju.edu.cn
研究领域 |
神经退行性病的发病机制
代谢异常影响中枢神经系统的机制
胶质细胞在神经系统发育过程中的作用
工作经历 |
2009-2012,南京大学生命科学学院,讲师
2012-至今 南京大学生命科学学院,副教授,博导
荣誉奖励 |
2008年,中华医学会二等奖,“中脑多巴胺系统发育和神经元变性”
2008年,上海市医学会二等奖,“帕金森病的基因调控和病理机制”
学术任职 |
中国生理学会青年委员
中国神经科学学会神经退行性疾病分会委员
代表性成果 |
Wang J, Li L, Zhang Z, Zhang X, Zhu Y, Zhang C, Bi Y. Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance. Cell Metab. 2022 Sep 6;34(9):1264-1279.e8.
Ding X, Wang J, Huang M, Chen Z, Liu J, Zhang Q, Zhang C, Xiang Y, Zen K, Li L. Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration. Nat Commun. 2021 Apr 1;12(1):2030.(2021年的ESI高被引论文,卓越期刊)
Zhou Z, Zhou Y, Jiang XM, Wang Y, Chen X, Xiao G, Zhang CY, Yi Y, Zhang LK, Li L. Decreased HD-MIR2911 absorption in human subjects with the SIDT1 polymorphism fails to inhibit SARS-CoV-2 replication. Cell Discov. 2020 Sep 11;6(1):63.
Wang J, Ding X, Wu X, Liu J, Zhou R, Wei P, Zhang Q, Zhang C, Zen K, Li L. SIRPα deficiency accelerates the pathologic process in models of Parkinson disease. Glia. 2019 Dec;67(12):2343-2359.
Mao S, Li X, Wang J, Ding X, Zhang C, Li L. miR-17-92 facilitates neuronal differentiation of transplanted neural stem/precursor cells under neuroinflammatory conditions. J Neuroinflammation. 2016 Aug 27;13(1):208.
Mao S, Sun Q, Xiao H, Zhang C, Li L. Secreted miR-34a in astrocytic shedding vesicles enhanced the vulnerability of dopaminergic neurons to neurotoxins by targeting Bcl-2. Protein Cell. 2015 Jul;6(7):529-540.