副教授、博士生导师,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:qijl@nju.edu.cn
研究领域 |
植物药用天然产物合成调控功能基因组学
工作经历 |
2021,南京大学博士生导师
2014-2016, 美国加州大学伯克利分校(University of California, Berkeley),植物与微生物学系(Department of Plant & Microbial Biology),访问学者
2011-2014,南京大学淮安高新技术研究院,兼职副研究员(A)
2011,南京大学副教授
荣誉奖励 |
2013,南京大学“优秀中青年教师境外研修计划”2年期项目入选者
2011,教育部“新世纪优秀人才支持计划”入选者
学术任职 |
2021-2026,中国农业生物技术学会第六届(2021.10-2026.9)理事会理事
2015-2026,江苏省遗传学会第九届、第十届理事会理事
代表性成果 |
[1] Chen QQ#, Han HW#, Lin FX, Yang LJ, Feng L, Lai XH, Wen ZL, Yang MK, Wang CY, Ma YD, Yin TM, Lu GH, Lin HY*, Qi JL*, Yang YH*. Novel shikonin derivatives suppress cell proliferation, migration and induce apoptosis in human triple-negative breast cancer cells via regulating PDK1/PDHC axis. Life Sciences, 2022, 310, 121077.
[2] Wang YF, Song H, Miao QJ, Wang YF, Qi JL*, Xu XL*, Sun JF*. PLA2G6 silencing suppresses melanoma progression and affects ferroptosis revealed by quantitative proteomics. Frontiers in Oncology, 2022, 12, 819235
[3] Lin HY#, Han HW#, Wang YS, He DL, Sun WX, Feng L, Wen ZL, Yang MK, Lu GH*, Wang XM*, Qi JL*, Yang YH*. Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo. Chinese medicine, 2020, 15(1), 1-14.
[4] Lin HY#, Han HW#, Sun WX, Yang YS, Tang CY, Lu GH, Qi JL*, Wang XM*, Yang YH*. Design and characterization of α-lipoic acyl shikonin ester twin drugs as tubulin and PDK1 dual inhibitors. European Journal of Medicinal Chemistry, 2018, 144:137-150
[5] Song H, Tao Y, Ni NN, Zhou XW, Xiong JS, Zeng XS, Xu XL*, Qi JL*, Sun JF*. miR-128 targets the CC chemokine ligand 18 gene (CCL18) in cutaneous malignant melanoma progression. Journal of Dermatological Science, 2018, 91(3), 317-324.
[6] Lu GH#, Hua XM#, Liang L, Wen ZL, Du MH, Meng FF, Qi JL*, Tang CY*, Yang YH*. Identification of major rhizobacterial taxa affected by a glyphosate-tolerant soybean line via shotgun metagenomic approach. Genes, 2018, 9(4), 214
[7] Zhu Y#, Lu GH#, Bian ZW, Wu FY, Pang YJ, Wang XM, Yang RW, Tang CY*, Qi JL*, Yang YH*. Involvement of LeMDR, an ATP-binding cassette protein gene, in shikonin transport and biosynthesis in Lithospermum erythrorhizon. BMC Plant Biology, 2017, 17:198
[8] Fang RJ, Zou AL, Zhao H, Wu FY, Zhu Y, Zhao H, Liao YH, Tang RJ, Pang YJ, Yang RW, Wang XM, Qi JL*, Lu GH*, Yang YH*. Transgenic studies reveal the positive role of LeEIL-1 in regulating shikonin biosynthesis in Lithospermum erythrorhizon hairy roots. BMC Plant Biology, 2016, 16: 121
[9] Fang RJ, Wu FY, Zou AL, Zhu Y, Zhao H, Zhao H, Liao YH, Tang R, Yang TY, Pang YJ, Wang XM, Yang RW, Qi JL*, Lu GH*, Yang YH*. Transgenic analysis reveals LeACS-1 as a positive regulator of ethylene-induced shikonin biosynthesis in Lithospermum erythrorhizon hairy roots. Plant Molecular Biology, 2016, 90(4): 345-358
[10] 杨荣武 主编;杜希华,赫福霞,李根喜,戚金亮,沈萍萍,杨荣武,杨永华,郑典元 参编.《生化学原理》,高等教育出版社,北京,2012.9
团队风采 |