- 万国强
副教授，医药生物技术国家重点实验室
地址：南京市栖霞区仙林大道163号，210023
邮箱：guoqiangwan@nju.edu.cn
| 研究领域 |
听觉遗传和发育生物学
| 工作经历 |
2017-，南京大学博士生导师
2016-，南京大学副教授
2014-2016，美国密歇根大学博士后
2011-2014，美国哈佛医学院博士后
| 学术任职 |
2020-2023，中国细胞生物学会-发育生物学分会，秘书长
2019-2023，江苏省发育生物学会-青年委员会，主任委员
2022-2026，江苏省发育生物学会-听觉科学专业委员会，主任委员
| 代表性成果 |
1. Liu, Q., Zhang, L., Zhu, M.S., and Wan, G. (2021). High-throughput screening on cochlear organoids identifies VEGFR-MEK-TGFB1 signaling promoting hair cell reprogramming. Stem Cell Reports, 16:2257-2273.
2. Yu, C., Gao, H.M., and Wan, G. (2021). Macrophages Are Dispensable for Postnatal Pruning of the Cochlear Ribbon Synapses. Frontiers in Cellular Neuroscience, 15:736120.
3. Chen, Z., Huang, Y., Yu, C., Liu, Q., Qiu, C., and Wan, G. (2021). Cochlear Sox2+ glial cells are potent progenitors for spiral ganglion neuron reprogramming induced by small molecules. Frontiers in Cell and Developmental Biology, 9:728352.
4. Zhu, G.J.*, Gong, S.*, Ma, D.B.*, Tao, T.*, He, W.Q.*, Zhang, L., Wang, F., Qian, X.Y., Zhou, H., Fan, C., Wang, P., Chen, X., Zhao, W., Sun, J., Chen, H., Wang, Y., Gao, X., Zuo, J., Zhu, M.S.#, Gao, X.#, and Wan, G.# (2020). Aldh inhibitor restores auditory function in a mouse model of human deafness. PLOS Genetics, 16(9):e1009040.
5. Du, H.*, Ye, C.*, Wu, D.*, Zang, Y.Y., Zhang, L., Chen, C., He, X.Y., Yang, J.J., Hu, P., Xu, Z., Wan, G.#,and Shi, Y.S.# (2020). The cation channel TMEM63B is an osmosensor required for hearing. Cell Reports, 31(5):107596.
6. Kohrman, D.C.*, Wan, G.*, Cassinotti, L.*, and Corfas, G. (2020). Hidden Hearing Loss: A Disorder with Multiple Etiologies and Mechanisms. Cold Spring Harbor Perspectives in Medicine, 10(1):a035493.
7. Wan, G.*,#, Ji, L.*, Schrepfer, T., Gong, S., Wang, G.P., and Corfas G.# (2019). Synaptopathy as a Mechanism for Age-Related Vestibular Dysfunction in Mice. Frontiers in Aging Neuroscience, 11:156.
8. Wan, G.#, and Corfas, G.# (2017). Transient auditory nerve demyelination as a new mechanism for hidden hearing loss. Nature Communications, 8, 14487.
9. Wan, G., Gómez-Casati, M.E., Gigliello, A.R., Liberman, M.C., and Corfas, G. (2014). Neurotrophin-3 regulates ribbon synapse density in the cochlea and induces synapse regeneration after acoustic trauma. eLife, 3, e03564.
10. Mellado Lagarde, M.M.*, Wan, G.*, Zhang, L., Gigliello, A.R., McInnis, J.J., Zhang, Y., Bergles, D.E., Zuo, J.#, and Corfas, G.# (2014). Spontaneous regeneration of cochlear supporting cells after neonatal ablation ensures hearing in the adult mouse. Proceedings of the National Academy of Sciences of the USA, 111(47), 16919-24.
| 团队风采 |
