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  • 袁阿虎

副教授,南京大学医学院,医药生物技术国家重点实验室

地址:南京市汉口路22号,210093

邮箱:yuannju@nju.edu.cn








研究领域


微/纳米药物及其在肿瘤免疫治疗中的应用



工作经历


2019.12~至今 南京大学医学院 副教授

2015.09~2019.11 南京大学医学院 副研究员




荣誉奖励


[1] 2018年,《抗肿瘤纳米药物制备的关键技术及其应用》,教育部技术发明一等奖(第3完成人);

[2] 2018年,南京市高层次人才(高校C类人才);

[3] 2019年,《一种制备用于体内递送药理活性物质的蛋白纳米粒的方法》,江苏省专利金奖(主要专利发明人);

[4] 2021年,《基于生物材料为载体的纳米药物基础研究》,教育部自然科学一等奖(第4完成人);

[5] 2022年,江苏省第六期333高层次人才(第三层次)



学术任职


中国药学会 会员;中国化学会 会员;

Nature Communications, Advanced Materials、ACS Nano、J Controlled Release等期刊审稿人




代表性成果

[1] Yuxiang Wang, Jing Chen, Rumeng Duan, Rong Gu, Weiran Wang, Jinhui Wu, Huibo Lian*, Yiqiao Hu*, Ahu Yuan*,High-Z-Sensitized Radiotherapy Synergizes with the Intervention of the Pentose Phosphate Pathway for In Situ Tumor Vaccination,Advanced Materials, 2022

[2] Zhusheng Huang, Dan Yao, Jinhui Wu, Yiqiao Hu* and Ahu Yuan*, Gadolinium–Zoledronic acid Coordination Polymer Nanorods for Improved Tumor Radioimmunotherapy by Synergetically Inducing Immungenic Cell Death and Reprogramming Immunosuppressive Microenvironment, ACS nano, 2021, 15, 5, 8450–8465

[3] Zhusheng Huang, Yuxiang Wang, Dan Yao, Jinhui Wu, Yiqiao Hu*, Ahu Yuan*, Nanoscale coordination polymers induce immunogenic cell death by amplifying radiation therapy mediated oxidative stress, Nat Commun, 2021 Jan 8;12(1)

[4] Yuxiang Wang, Yawen Ding, Dan Yao, Hong Dong, Changwei Ji*, Jinhui Wu, Yiqiao Hu* and Ahu Yuan*, Copper-Based Nanoscale Coordination Polymers Augmented Tumor Radioimmunotherapy for Immunogenic Cell Death Induction and T-Cell Infiltration, Small 2021, 17, 2006231

[5] Li Wang, Zhicheng Zhang, Yawen Ding, Jinhui Wu, Yiqiao Hu* and Ahu Yuan*,Novel copper-based and pH-sensitive nanomedicine for enhanced chemodynamic therapy, Chem. Commun., 2020, 56

[6] Shaoju Gan, Xiaoning Tong , Yue Zhang, Jinhui Wu, Yiqiao Hu*, and Ahu Yuan*,Covalent Organic Framework-Supported Molecularly Dispersed Near-Infrared Dyes Boost Immunogenic Phototherapy against Tumors,Advanced Functional Materials, 2019, 29, 1902757 (Cover Story)

[7] W. Wang, Y. Cheng, P. Yu, H. Wang, Y. Zhang, H. Xu, Q. Ye, A. Yuan*, Y. Hu*, J. Wu*, Perfluorocarbon regulates the intratumoural environment to enhance hypoxia-based agent efficacy, Nat Commun 10(1) (2019) 1580.

[8] Meng, L; Cheng, Y; Tong, X; Gan, S; Ding, Y; Zhang, Y; Wang, C; Xu, L; Zhu, Y; Wu, J*; Hu, Y*; Yuan, A*. Tumor Oxygenation and Hypoxia Inducible Factor-1 Functional Inhibition Via a Reactive Oxygen Species Responsive Nanoplatform for Enhancing Radiation Therapy and Abscopal Effects. ACS Nano 2018 Aug 28;12(8):8308-8322.

更多论文:https://scholar.google.com/citations?hl=en&user=7ccGPxsAAAAJ



其他


[1] 2022-2025年,BK20221445,三级靶向纳米体系的构建及其用于定向调控肿瘤细胞线粒体功能诱导三阴性乳腺癌原位疫苗效应的研究,江苏省自然科学基金面上项目(项目负责人);

[2] 2018~2020年,乏氧肿瘤供氧驱动免疫激活克服放疗抵抗及转移,中央高校基本科研业务经费(项目负责人);

[3] 2016-2019年,81603043,基于可激活细胞穿膜肽递送siRNA治疗肝纤维化的研究,国家自然科学青年基金项目(项目负责人);

[4] 2017-2022年,2017YFA0205400,国家重点研发计划“纳米科技”重点专项,肿瘤乏氧微环境相关的纳米药物设计及其规模化制备研究(参与,研究骨干);