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  • 臧宇辉

副教授,医药生物技术国家重点实验室 

地址:南京市栖霞区仙林大道163号,210023

邮箱:zangyh@nju.edu.cn









研究领域


慢性肾病

器官纤维化



工作经历


2004-      南京大学 生命科学院,副教授

1997-2003  南京大学,生命科学院,讲师

1999-2001  国际遗传工程与生物技术中心(ICGEB, Italy),访问学者

1995-1997  南京大学,生物化学系,助教



荣誉奖励


2004  “以杆状病毒表达系统为技术平台研究药用重组蛋白质,江苏省科技进步奖一等奖 (排名第三)



代表性成果

[1] Sun Y, Cai H, Ge J, Shao F, Huang Z, Ding Z, Dong L, Chen J, Zhang J*, Zang Y*. Tubule-derived INHBB promotes interstitial fibroblast activation and renal fibrosis. J Pathol. 2022; 256(1): 25-37

[2] Ren Z, Chen Y, Shi L, Shao F, Sun Y, Ge J, Zhang J*, Zang Y*. Sox9/CXCL5 axis facilitates tumour cell growth and invasion in hepatocellular carcinoma. FEBS J. 2022; 289(12): 3535-3549

[3] Chen Y, Qian B, Sun X, Kang Z, Huang Z, Ding Z, Dong L, Chen J, Zhang Junfeng*, Zang Yuhui*. Sox9/INHBB axis-mediated crosstalk between the hepatoma and hepatic stellate cells promotes the metastasis of hepatocellular carcinoma. Cancer Lett. 2021; 499: 243-254.  

[4] Wang C, Deng J, Deng H, Kang Z, Huang Z, Ding Z, Dong L, Chen J, Zhang J*, Zang Y*. A novel Sox9/lncRNA H19 axis contributes to hepatocyte death and liver fibrosis. Toxicol Sci. 2020; 177:214-225. 

[5] Li H, Shao F, Qian B, Sun Y, Huang Z, Ding Z, Dong L, Chen J*, Zhang Jg*, Zang Y*. Upregulation of HER-2 in tubular epithelial cell drives fibroblast activation and renal fibrosis. Kidney Int. 2019; 96, 674–688. 

[6] Li H, Cai H, Deng J, Tu X, Sun Y, Huang Z, Ding Z, Dong L, Chen J, Zang Y*, Zhang J*. TGF-β-mediated upregulation of Sox9 in fibroblast promotes renal fibrosis. Biochim Biophys Acta Mol Basis Dis. 2018; 1864(2):520-532. 

[7] Tu X, Zhang Y, Zheng X, Deng J, Li H, Kang Z, Cao Z, Huang Z, Ding Z, Dong L, Chen J, Zang Y*, Zhang J*. TGF-beta-induced hepatocyte lincRNA-p21 contributes to liver fibrosis in mice. Sci Rep. 2017;7:41456. 

[8] Tu X, Zheng X, Li H, Cao Z, Chang H, Luan S, Zhu J, Chen J, Zang Y*, Zhang J*. MicroRNA-30 Protects against carbon tetrachloride-induced liver Fibrosis by attenuating transforming growth factor beta signaling in hepatic stellate cells. Toxicol Sci. 2015, 146: 157-169. 

[9] Tu X, Zhang H, Zhang J, Zhao S, Zheng X, Zhang Z, Zhu J, Chen J, Dong L, Zang Y*, Zhang J*. microRNA-101 suppresses liver fibrosis by targeting the TGFβ signalling pathway. J Pathol. 2014; 234: 46-59.