副教授,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:zangyh@nju.edu.cn
研究领域 |
慢性肾病
器官纤维化
工作经历 |
2004- 南京大学 生命科学院,副教授
1997-2003 南京大学,生命科学院,讲师
1999-2001 国际遗传工程与生物技术中心(ICGEB, Italy),访问学者
1995-1997 南京大学,生物化学系,助教
荣誉奖励 |
2004年 “以杆状病毒表达系统为技术平台研究药用重组蛋白质”,江苏省科技进步奖一等奖 (排名第三)
代表性成果 |
[1] Sun Y, Cai H, Ge J, Shao F, Huang Z, Ding Z, Dong L, Chen J, Zhang J*, Zang Y*. Tubule-derived INHBB promotes interstitial fibroblast activation and renal fibrosis. J Pathol. 2022; 256(1): 25-37
[2] Ren Z, Chen Y, Shi L, Shao F, Sun Y, Ge J, Zhang J*, Zang Y*. Sox9/CXCL5 axis facilitates tumour cell growth and invasion in hepatocellular carcinoma. FEBS J. 2022; 289(12): 3535-3549
[3] Chen Y, Qian B, Sun X, Kang Z, Huang Z, Ding Z, Dong L, Chen J, Zhang Junfeng*, Zang Yuhui*. Sox9/INHBB axis-mediated crosstalk between the hepatoma and hepatic stellate cells promotes the metastasis of hepatocellular carcinoma. Cancer Lett. 2021; 499: 243-254.
[4] Wang C, Deng J, Deng H, Kang Z, Huang Z, Ding Z, Dong L, Chen J, Zhang J*, Zang Y*. A novel Sox9/lncRNA H19 axis contributes to hepatocyte death and liver fibrosis. Toxicol Sci. 2020; 177:214-225.
[5] Li H, Shao F, Qian B, Sun Y, Huang Z, Ding Z, Dong L, Chen J*, Zhang Jg*, Zang Y*. Upregulation of HER-2 in tubular epithelial cell drives fibroblast activation and renal fibrosis. Kidney Int. 2019; 96, 674–688.
[6] Li H, Cai H, Deng J, Tu X, Sun Y, Huang Z, Ding Z, Dong L, Chen J, Zang Y*, Zhang J*. TGF-β-mediated upregulation of Sox9 in fibroblast promotes renal fibrosis. Biochim Biophys Acta Mol Basis Dis. 2018; 1864(2):520-532.
[7] Tu X, Zhang Y, Zheng X, Deng J, Li H, Kang Z, Cao Z, Huang Z, Ding Z, Dong L, Chen J, Zang Y*, Zhang J*. TGF-beta-induced hepatocyte lincRNA-p21 contributes to liver fibrosis in mice. Sci Rep. 2017;7:41456.
[8] Tu X, Zheng X, Li H, Cao Z, Chang H, Luan S, Zhu J, Chen J, Zang Y*, Zhang J*. MicroRNA-30 Protects against carbon tetrachloride-induced liver Fibrosis by attenuating transforming growth factor beta signaling in hepatic stellate cells. Toxicol Sci. 2015, 146: 157-169.
[9] Tu X, Zhang H, Zhang J, Zhao S, Zheng X, Zhang Z, Zhu J, Chen J, Dong L, Zang Y*, Zhang J*. microRNA-101 suppresses liver fibrosis by targeting the TGFβ signalling pathway. J Pathol. 2014; 234: 46-59.