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  • 张峻峰

教授,医药生物技术国家重点实验室 

地址:南京市栖霞区仙林大道163号,210023

邮箱:jfzhang@nju.edu.cn









研究领域


药物递送系统

生物治疗和纳米药物



工作经历


2002-现在,南京大学 生命科学学院医药生物技术国家重点实验室 教授

2000/02-2002/03,南京大学 生命科学学院 副教授

1997/07- 2000/02,国立新加坡大学 生物医学工程系  访问学者



荣誉奖励


2012年,教育部长江学者特聘教授

2010年,国家杰出青年科学基金

2004年,国家自然科学二等奖



学术任职


江苏省药物研究与开发协会副理事长

Asian Journal of Pharmaceutical Sciences编委




代表性成果

1. Sun Y, Cai H, Ge J, Shao F, Huang Z, Ding Z, Dong L, Chen J, Zhang J#, Zang Y#. Tubule-derived INHBB promotes interstitial fibroblast activation and renal fibrosis. J Pathol. 2022; 256(1):25-37.

2. Xing Z, Xue J, Ma X, Han C, Wang Z, Luo S, Wang C#, Dong L#, Zhang J#. Intracellular mRNA phase separation induced by cationic polymers for tumor immunotherapy. J Nanobiotechnology. 2022; 20(1):442. 

3. Wang Y, Pang J, Wang Q, Yan L, Wang L, Xing Z, Wang C#, Zhang J#, Dong L#. Delivering Antisense Oligonucleotides across the Blood-Brain Barrier by Tumor Cell-Derived Small Apoptotic Bodies. Adv Sci (Weinh). 2021; 8(13):2004929. 

4. He W, Xu J, Mu R, Li Q, Lv DL, Huang Z, Zhang J#, Wang C#, Dong L#. High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation. Nat Commun. 2020; 11(1):1732. 

5. Fu Y, Ni J, Chen J, Ma G, Zhao M, Zhu S, Shi T, Zhu J, Huang Z#, Zhang J#, Chen J#. Dual-Functionalized MSCs that Express CX3CR1 and IL-25 Exhibit Enhanced Therapeutic Effects on Inflammatory Bowel Disease. Mol Ther. 2020; 28(4):1214-1228. 

6. Li H, Shao F, Qian B, Sun Y, Huang Z, Ding Z, Dong L, Chen J#, Zhang J#, Zang Y#. Upregulation of HER2 in tubular epithelial cell drives fibroblast activation and renal fibrosis. Kidney Int. 2019; 96(3):674-688. 

7. Wang L, Chen Q, Qi H, Wang C, Wang C, Zhang J#, Dong L#. Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage. Cancer Res. 2016; 76(22):6631-6642. 

8. Huang Z, Gan J, Long Z, Guo G, Shi X, Wang C, Zang Y, Ding Z, Chen J, Zhang J#, Dong L#. Targeted delivery of let-7b to reprogramme tumor-associated macrophages and tumor infiltrating dendritic cells for tumor rejection. Biomaterials. 2016; 90:72-84.

9. Zhang Z, Wang C, Zha Y, Hu W, Gao Z, Zang Y, Chen J, Zhang J#, Dong L#. Corona-directed nucleic acid delivery into hepatic stellate cells for liver fibrosis therapy. ACS Nano. 2015; 9(3):2405-19. 

10. Huang Z, Gan J, Jia L, Guo G, Wang C, Zang Y, Ding Z, Chen J, Zhang J#, Dong L#. An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease. Biomaterials. 2015; 48:26-36. 


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