教授,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:jfzhang@nju.edu.cn
研究领域 |
药物递送系统
生物治疗和纳米药物
工作经历 |
2002-现在,南京大学 生命科学学院医药生物技术国家重点实验室 教授
2000/02-2002/03,南京大学 生命科学学院 副教授
1997/07- 2000/02,国立新加坡大学 生物医学工程系 访问学者
荣誉奖励 |
2012年,教育部长江学者特聘教授
2010年,国家杰出青年科学基金
2004年,国家自然科学二等奖
学术任职 |
江苏省药物研究与开发协会副理事长
Asian Journal of Pharmaceutical Sciences编委
代表性成果 |
1. Sun Y, Cai H, Ge J, Shao F, Huang Z, Ding Z, Dong L, Chen J, Zhang J#, Zang Y#. Tubule-derived INHBB promotes interstitial fibroblast activation and renal fibrosis. J Pathol. 2022; 256(1):25-37.
2. Xing Z, Xue J, Ma X, Han C, Wang Z, Luo S, Wang C#, Dong L#, Zhang J#. Intracellular mRNA phase separation induced by cationic polymers for tumor immunotherapy. J Nanobiotechnology. 2022; 20(1):442.
3. Wang Y, Pang J, Wang Q, Yan L, Wang L, Xing Z, Wang C#, Zhang J#, Dong L#. Delivering Antisense Oligonucleotides across the Blood-Brain Barrier by Tumor Cell-Derived Small Apoptotic Bodies. Adv Sci (Weinh). 2021; 8(13):2004929.
4. He W, Xu J, Mu R, Li Q, Lv DL, Huang Z, Zhang J#, Wang C#, Dong L#. High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation. Nat Commun. 2020; 11(1):1732.
5. Fu Y, Ni J, Chen J, Ma G, Zhao M, Zhu S, Shi T, Zhu J, Huang Z#, Zhang J#, Chen J#. Dual-Functionalized MSCs that Express CX3CR1 and IL-25 Exhibit Enhanced Therapeutic Effects on Inflammatory Bowel Disease. Mol Ther. 2020; 28(4):1214-1228.
6. Li H, Shao F, Qian B, Sun Y, Huang Z, Ding Z, Dong L, Chen J#, Zhang J#, Zang Y#. Upregulation of HER2 in tubular epithelial cell drives fibroblast activation and renal fibrosis. Kidney Int. 2019; 96(3):674-688.
7. Wang L, Chen Q, Qi H, Wang C, Wang C, Zhang J#, Dong L#. Doxorubicin-Induced Systemic Inflammation Is Driven by Upregulation of Toll-Like Receptor TLR4 and Endotoxin Leakage. Cancer Res. 2016; 76(22):6631-6642.
8. Huang Z, Gan J, Long Z, Guo G, Shi X, Wang C, Zang Y, Ding Z, Chen J, Zhang J#, Dong L#. Targeted delivery of let-7b to reprogramme tumor-associated macrophages and tumor infiltrating dendritic cells for tumor rejection. Biomaterials. 2016; 90:72-84.
9. Zhang Z, Wang C, Zha Y, Hu W, Gao Z, Zang Y, Chen J, Zhang J#, Dong L#. Corona-directed nucleic acid delivery into hepatic stellate cells for liver fibrosis therapy. ACS Nano. 2015; 9(3):2405-19.
10. Huang Z, Gan J, Jia L, Guo G, Wang C, Zang Y, Ding Z, Chen J, Zhang J#, Dong L#. An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease. Biomaterials. 2015; 48:26-36.
团队风采 |