副教授、硕导,医药生物技术国家重点实验室
地址:南京市栖霞区仙林大道163号,210023
邮箱:xuchn@nju.edu.cn
研究领域 |
代谢和衰老
工作经历 |
2002.7~:南京大学生命科学学院,讲师、副教授
2009. 10~2011. 10:美国哥伦比亚大学医学院,访问学者
2015.9~2016.9:ISEF fellow
2018.9~2018.12, 美国加州大学洛杉矶分校,医学院药理系,访问学者
代表性成果 |
[1] Yu Cheng, Bing-Hao Hou, Gui-Lin Xie, Ya-Ting Shao, Jie Yang **, Chen Xu*. Transient inhibition of mitochondrial function by chrysin and apigenin prolong longevity via mitohormesis in C. elegans. Free Radical Biology and Medicine 2023, 203: 24-33. https://doi.org/10.1016/j.freeradbiomed.2023.03.264
[2] Shuzhen Yu, Yating Shao, Qineng Qiu, Yu Cheng, Renkun Qing, Cai-Feng Wang, Su Chen*, Chen Xu*. Photo-and thermo-regulation by photonic crystals for extended longevity of C. elegans. Mechanisms of Ageing and Development 2023, 212: 111819. https://doi.org/10.1016/j.mad.2023.111819
[3] Z. Zhu, T. Yang, L. Zhang, L. Liu, E. Yin, C. Zhang, Z. Guo, C. Xu**, X. Wang*. Inhibiting Ab toxicity in Alzheimer's disease by a pyridine amine derivative. European Journal of Medicinal Chemistry 2019, 168, 330-339. https://doi.org/10.1016/j.ejmech.2019.02.052
[4] C. Xu†*, W. Hwang†, D. Jeong, Y. Ryu; C. Ha, S.V. Lee; L. Liu; Z. He. Genetic inhibition of an ATP synthase subunit extends lifespan in C. elegans. Scientific Reports, 2018, 8: 14836. https://10.1038/s41598-018-32025-w.
[5] B. Yang, M. Su, Y. Xue, Z. He*, C. Xu*, H. Zhu*. A selective fluorescence probe for H2S from biothiols with a significant regioselective turn-on response and its application for H2S detection in living cells and in living Caenorhabditis elegans. Sensors & Actuators: B. Chemical 2018, 276: 456-465. https://doi.org/10.1016/j.snb.2018.08.138
[6] Chen Xu, Junhua Zhang, Doina M. Mihai, Ilyas Washington*. Light-harvesting chlorophyll pigments enable mammalian mitochondria to capture photonic energy and produce ATP. Journal of Cell Science 2014, 127, 388-399. https://doi.org/10.1242/jcs.134262.