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  • 程远明

教授、博导,医药生物技术国家重点实验室 

地址:南京市仙林校区仙林大道163号,210023

邮箱:ymcheng@nju.edu.cn









研究领域


干细胞和肿瘤的表观调控


工作经历


2016-2021,纪念斯隆凯特琳癌症中心,研究学者

2022-,南京大学教授



荣誉奖励


2022,国家高层次青年人才项目优青(海外)



杂志任职


2023-,《Journal of Nanobiotechnology》(IF: 10.2) 客座编辑

2023-,《Frontiers in Genome Editing》客座编辑



代表性成果

[1] Cheng, Y.#, Xie, W.#, Pickering, B.F., Chu, K.L., Savino, A.M., Yang, X., Luo, H., Nguyen, D.T., Mo, S., Barin, E., Velleca, A., Rohwetter, T., Patel, D.J., Jaffrey, S.R., Kharas, M.G.. N6-methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cancer Cell. 2021, 39 (7), 958-972. e8. 

原文链接:https://doi.org/10.1016/j.ccell.2021.04.017

[2] Vu, L. P. #, Pickering, B. F. #, Cheng, Y. # (equal contribution), Zaccara, S., Nguyen, D., Minuesa, G., Chou, T., Chow, A., Saletore, Y., MacKay, M., et al.. The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nature Medicine. 2017, 23, 1369-1376. (Cover paper)

原文链接:http://doi:10.1038/nm.4416

[3] Cheng, Y.#, Luo, H.#, Izzo, F.#, Pickering, B. F., Nguyen, D., Myers, R., Schurer, A., Gourkanti, S., Bruning, J. C., Vu, L. P., et al. . m(6)A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment. Cell Reports. 2019, 28, 1703-1716 e1706.

原文链接:https://doi.org/10.1016/j.celrep.2019.07.032

[4] Cheng, Y., Luo, H., and Kharas, M. G.. Rubbing Out Leukemia Stem Cells by Erasing the Eraser. Cell Stem Cell.2022, 27, 3-5.

原文链接:https://doi.org/10.1016/j.stem.2020.06.009

[5] Vu, L. P., Cheng, Y., and Kharas, M. G.. The Biology of m(6)A RNA Methylation in Normal and Malignant Hematopoiesis. Cancer Discovery. 2019, 9, 25-33. 

原文链接:https://doi.org/10.1158/2159-8290.CD-18-0959

[6] Cheng, Y., Luo, C., Wu, W., Xie, Z., Fu, X., and Feng, Y.. Liver-Specific Deletion of SRSF2 Caused Acute Liver Failure and Early Death in Mice. Mol. Cell. Biol. 2016, 36, 1628-1638.

原文链接:https://doi.org/10.1128/MCB.01071-15

[7] Wei, N.#, Cheng, Y. # (equal contribution), Wang, Z., Liu, Y., Luo, C., Liu, L., Chen, L., Xie, Z., Lu, Y., and Feng, Y.. SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. Cell Reports. 2015, 13, 1647-1657.

原文链接:https://doi.org/10.1016/j.celrep.2015.10.038

[8] Li, H. #, Cheng, Y. # (equal contribution), Wu, W., Liu, Y., Wei, N., Feng, X., Xie, Z., and Feng, Y.. SRSF10 regulates alternative splicing and is required for adipocyte differentiation. Mol. Cell. Biol. 2014, 34, 2198-2207.

原文链接:https://doi.org/10.1128/MCB.01674-13

[9] Xu, G. #, Chhangawala, S. #, Cocco, E., Razavi, P., Cai, Y., Otto, J. E., Ferrando, L., Selenica, P., Ladewig, E., Chan, C., Da Cruz Paula, A., Witkin, M., Cheng, Y., Park, J.,  et al.. ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer. Nature Genetics. 2020, 52, 198-207.

原文链接:https://doi.org/10.1038/s41588-019-0554-0oi.org/10.1038/s41588-019-0554-0

[10] Su, W., Han, H. H., Wang, Y., Zhang, B., Zhou, B., Cheng, Y., Rumandla, A., Gurrapu, S., Chakraborty, G., Su, J., et al.. The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression. Cancer Cell. 2019, 36, 139-155 e110.

原文链接:https://doi.org/10.1016/j.ccell.2019.06.009


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