工作经历
2002-现在，南京大学 生命科学学院医药生物技术全国重点实验室 教授
2000/02-2002/03，南京大学 生命科学学院 副教授
1997/07- 2000/02，国立新加坡大学 生物医学工程系 访问学者
荣誉奖励
1.2023年国家自然科学二等奖
2.2011年教育部科学技术一等奖
3.2004年国家自然科学二等奖
4.2003年教育部科学技术一等奖
学术任职
江苏省药物研究与开发协会副理事长
Asian Journal of Pharmaceutical Sciences编委
代表性成果
1. Zhao X, Jing W, Wang G, Liu Z, Xu X, Han M, Fu Z, Zhang Y, Zheng Z, Zhang J, Bo L, Dong X, Li C, Sun Y, Zhang J*, Zhao F*, Xing N*, Zhao K*, Jiang X*. A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors. Nat Biotechnol. 2026 Mar 13. doi: 10.1038/s41587-026-03057-9.
2. Ji S, Wang F, Wu Y, Hu H, Xing Z, Zhu J, Xu S, Han T, Liu G, Wu Z, Fei C, Kong L, Chen J, Ding Z*, Huang Z*, Zhang J*. Large-scale transcript variants dictate neoepitopes for cancer immunotherapy. Sci Adv. 2025;11(5):eado5600.
3. Gao C, Hong F, Dong Y, Fu Y, Ma Y, Sun X, Zhang J, Chen J, Huang Z. Lifespan-Regulated CAR-Macrophages from Myeloid Progenitors for Enhanced Colorectal Cancer Therapy. Adv Sci (Weinh). 2025;12(43):e17677.
4. Wang L, Sun Y, Yang L, Wang S, Liu C, Wang Y, Niu Y, Huang Z, Zhang J*, Wang C*, Dong L*. Engineering an energy-dissipating hybrid tissue in vivo for obesity treatment. Cell Rep. 2024;43(7):114425.
5. Kang Z, Wang C, Shao F, Deng H, Sun Y, Ren Z, Zhang W, Ding Z, Zhang J*, Zang Y*. The increase of long noncoding RNA Fendrr in hepatocytes contributes to liver fibrosis by promoting IL-6 production. J Biol Chem. 2024;300(6):107376.
6. Xing Z, Xue J, Ma X, Han C, Wang Z, Luo S, Wang C, Dong L, Zhang J. Intracellular mRNA phase separation induced by cationic polymers for tumor immunotherapy. J Nanobiotechnology. 2022;20(1):442.
7. Liu C, Wang L, Xu M, Sun Y, Xing Z, Zhang J*, Wang C*, Dong L*. Reprogramming the spleen into a functioning 'liver' in vivo. Gut. 2022;71(11):2325-2336.
8. Wang Y, Pang J, Wang Q, Yan L, Wang L, Xing Z, Wang C*, Zhang J*, Dong L*. Delivering Antisense Oligonucleotides across the Blood-Brain Barrier by Tumor Cell-Derived Small Apoptotic Bodies. Adv Sci (Weinh). 2021;8(13):2004929.
9. Wang L, Wang C, Wang Z, Gan J, Liu C, Xia S, Niu Y, Chen D, Zhang J*, Dong L*. Transforming the spleen into a liver-like organ in vivo. Sci Adv. 2020;6(24):eaaz9974.
10. He W, Xu J, Mu R, Li Q, Lv DL, Huang Z, Zhang J*, Wang C*, Dong L*. High-salt diet inhibits tumour growth in mice via regulating myeloid-derived suppressor cell differentiation. Nat Commun. 2020;11(1):1732.
