工作经历
2013-2015，江苏大学药学院 讲师
2015-2021，南京大学生命科学学院 副教授
2020-，南京大学生命科学学院 博导
2022-，南京大学生命科学学院 教授
荣誉奖励
1. 2022年江苏省医学科技奖二等奖（2/8）
2. 2021年江苏高校“青蓝工程”优秀教学团队（2/8）
3. 2019年中国药理学会-施维雅青年药理学家奖
4. 2018年度江苏省教育教学与研究成果二等奖（1/5）
5. 2018年教育部自然科学一等奖（2/8）
6. 2015年第十九届“中国药理学会青年药理学家奖”
7. 2015年度南京大学优秀博士学位论文
8. 2015年度江苏省优秀博士学位论文
学术任职
2020-,《药学学报》《APSB》 青年编委编委
2018-，世界中医药学会联合会中医药免疫专业委员会常务理事
2019-，中国药理学会抗炎免疫药理专委会 副秘书长
代表性成果
2025
2. Jiazhen Zhu#, Xiaofei Li#, Wenbo Chen, Zhenqi Zuo, Qin Gong, Jinbo Hu, Kai Huang, Wen Liu*, Yanhong Gu*, Qiang Xu*, Wenjie Guo*, Ferroptosis triggers anti-tumor immunity via promoting chaperone-mediated autophagic degradation of SHP2. Redox Biol,2025,86:103796.
1. Lijun Zhu#, Zhaohui Tang#, Wen Jiang#, Yuwen Dong, Xiaofei Li, Kai Huang, Tiancong Wu*, Lingyan Xu*, Wenjie Guo*, Yanhong Gu*, Cholesterol Biosynthesis Induced by Radiotherapy Inhibits cGAS-STING Activation and Contributes to Colorectal Cancer Treatment Resistance. Exp Mol Med. 2025;57(5):1089-1105.
2024
3. Chen He, Junkai Liu, Junda Li, Hongyu Wu, Chenyang Jiao, Xiaotong Ze, Shengtao Xu,* Zheying Zhu, Wenjie Guo*, Jinyi Xu*, Hong Yao*, Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity. J Med Chem 2024; 67(11): 9406-30.
2. Jinbo Hu#, Wen Liu#, *, Yi Zou#, Chenyang Jiao, Jiazhen Zhu, Jianjun Zou*, Yang Sun*, Qiang Xu, Wenjie Guo*, Allosterically activating SHP2 using oleanolic acid inhibited the STAT3-Th17 axis and ameliorated colitis, Acta Pharmaceutica Sinica B, 2024; 14(6): 2598-612.
1. Longbo Yu#, Lingyan Xu#, Yunjie Chen, Yicheng Rong, Yi Zou,Shushan Ge, TiancongWu*, Yisheng Lai*,Qiang Xu, Wenjie Guo*,Wen Liu*, IDO1 inhibition promotes activation of tumor-intrinsic STAT3 pathway and induces adverse tumor-protective effects, J Immunol 2024; 212(7): 1232-43.
2023
3. Wu Xiaohan #, Xu Lingyan#, Li Xiaofei#, Zhou Yirui, Han Xiao, Zhang Wei, Wang Weicheng, Wenjie Guo*, Liu Wen*, Xu Qiang, Gu Yanhong*, A HER2-targeting antibody-MMAE conjugate RC48 sensitizes immunotherapy in HER2-positive colon cancer by triggering the cGAS-STING pathway. Cell Death & Disease 2023; 14(8).
2. Chao Luan#, He Yingxue#, Liu Wen, Rong Yicheng, Gao Jian, Xu Kang, Yu Hui, Hu Yu, Zhang Jiaan*, Chen Kun*, Wenjie Guo*, PCSK9 inhibition interrupts the cross talk between keratinocytes and macrophages and prevents UVB-induced skin damage. J Bio Chem. 2023; 299(7):104895.
1.焦晨阳，李艳，徐强，郭文洁,嘌呤霉素敏感的氨肽酶结构与功能研究进展。药学学报,2023。
2022
3. Wen Liu#, Jiashu Yang#, Shihao Fang#, Chenyang Jiao, Jianhua Gao, Aihua Zhang *, Tiancong Wu*, Renxiang Tan, Qiang Xu, Wenjie Guo*, Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC, J Bio Chem. 2022; 298(12): 102696.
2. Liu Wen#; Zou Yi#; Li Kaiming#; Zhong Haiqing; Yu Longbo; Ge Shushan; Lai Yisheng*; Xianchi Dong*; Xu Qiang*; Guo Wenjie*; Apo-form selective inhibition of indoleamine-2,3-dioxygenase for tumor immunotherapy, J Immunol. 2022;209(1): 180- 191.
1. Yuanyuan Wang#, Bin Wei#, Danping Wang#, Jingjing Wu, Jianhua Gao, Haiqing Zhong, Yang Sun, Qiang Xu, Wen Liu *, Yanhong Gu*, Wenjie Guo*, DNA damage repair promotion in colonic epithelial cells by Andrographolide downregulated cGAS‒STING pathway activation and contributed to the relief of CPT-11‒induced intestinal mucositis. Acta Pharmaceutica Sinica B 2022; 12(1): 262-273.
2021
1. Wei Bin#; Xu Lingyan#; Wenjie Guo #; Wang Yuanyuan; Wu Jingjing; Li Xiaofei; Cai Xiaomin; Hu Jinbo; Wang Meijing; Xu Qiang; Liu Wen*; Gu Yanhong*; SHP2-mediated inhibition of DNA repair contributes to cGAS-STING activation and chemotherapeutic sensitivity in colon cancer.Cancer Research 2021: canres.3738.2020.
申请/授权发明专利情况：
1. 徐强，孙洋，刘雯，吴静，郭文洁，苯并咪唑类化合物及其应用，授权：CN103113307B。
2. 谭仁祥，徐强，孙洋，吴汉夔，戈惠明，龚方苑，罗琼，郭文洁，苯基苄胺类化合物及其应用，授权：CN102627578A。
3.孙洋，徐强，郭文洁，吴兴新，邵粉丽，一种基于条件性敲除技术的脊柱关节炎小鼠模型的建立方法及用途，申请号：CN201610634114.0，公开号： CN106177999A。
4. 茚满酮类化合物及其生物素衍生物、制备方法、应用，张爱华，郭文洁，刘雯，房世豪。
5. 用于治疗和/或预防炎症性皮肤病的氨苯蝶啶及其组合物，郭文洁、左真齐、焦晨阳、高健、刘雯、荣一丞，中国发明专利申请号：CN202411452946。
