工作经历
2016-2021,纪念斯隆凯特琳癌症中心,研究学者
2022-,南京大学教授
荣誉奖励
2022,国家高层次青年人才项目优青(海外)
学术任职
2023-,《Journal of Nanobiotechnology》(IF: 10.2) 客座编辑
2023-,《Frontiers in Genome Editing》客座编辑
代表性成果
[1] Cheng, Y.#, Xie, W.#, Pickering, B.F., Chu, K.L., Savino, A.M., Yang, X., Luo, H., Nguyen, D.T., Mo, S., Barin, E., Velleca, A., Rohwetter, T., Patel, D.J., Jaffrey, S.R., Kharas, M.G.. N6-methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cancer Cell. 2021, 39 (7), 958-972. e8.
[2] Vu, L. P. #, Pickering, B. F. #, Cheng, Y. # (equal contribution), Zaccara, S., Nguyen, D., Minuesa, G., Chou, T., Chow, A., Saletore, Y., MacKay, M., et al.. The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nature Medicine. 2017, 23, 1369-1376. (Cover paper)
[3] Cheng, Y.#, Luo, H.#, Izzo, F.#, Pickering, B. F., Nguyen, D., Myers, R., Schurer, A., Gourkanti, S., Bruning, J. C., Vu, L. P., et al. . m(6)A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment. Cell Reports. 2019, 28, 1703-1716 e1706.
[4] Cheng, Y., Luo, H., and Kharas, M. G.. Rubbing Out Leukemia Stem Cells by Erasing the Eraser. Cell Stem Cell.2022, 27, 3-5.
[5] Vu, L. P., Cheng, Y., and Kharas, M. G.. The Biology of m(6)A RNA Methylation in Normal and Malignant Hematopoiesis. Cancer Discovery. 2019, 9, 25-33.
[6] Cheng, Y., Luo, C., Wu, W., Xie, Z., Fu, X., and Feng, Y.. Liver-Specific Deletion of SRSF2 Caused Acute Liver Failure and Early Death in Mice. Mol. Cell. Biol. 2016, 36, 1628-1638.
[7] Wei, N.#, Cheng, Y. # (equal contribution), Wang, Z., Liu, Y., Luo, C., Liu, L., Chen, L., Xie, Z., Lu, Y., and Feng, Y.. SRSF10 Plays a Role in Myoblast Differentiation and Glucose Production via Regulation of Alternative Splicing. Cell Reports. 2015, 13, 1647-1657.
[8] Li, H. #, Cheng, Y. # (equal contribution), Wu, W., Liu, Y., Wei, N., Feng, X., Xie, Z., and Feng, Y.. SRSF10 regulates alternative splicing and is required for adipocyte differentiation. Mol. Cell. Biol. 2014, 34, 2198-2207.
[9] Xu, G. #, Chhangawala, S. #, Cocco, E., Razavi, P., Cai, Y., Otto, J. E., Ferrando, L., Selenica, P., Ladewig, E., Chan, C., Da Cruz Paula, A., Witkin, M., Cheng, Y., Park, J., et al.. ARID1A determines luminal identity and therapeutic response in estrogen-receptor-positive breast cancer. Nature Genetics. 2020, 52, 198-207.
[10] Su, W., Han, H. H., Wang, Y., Zhang, B., Zhou, B., Cheng, Y., Rumandla, A., Gurrapu, S., Chakraborty, G., Su, J., et al.. The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression. Cancer Cell. 2019, 36, 139-155 e110.