南京市栖霞区仙林大道163号，210023
zhangqing@nju.edu.cn
工作经历
2009-至今，南京大学博士生导师
2009-至今，南京大学教授
2003-2009，博士后，UT Southwestern Medical Center at Dallas
荣誉奖励
学术任职
美国遗传学会会员
中国细胞生物学学会会
代表性成果
1. Li S#, Shan Z#, Zhao G, Li Y, Du M, Ti X, Gao Y, Li W, Zuo H, Wang Y*, Zhang Q*. (2025) Impaired mitochondria-initiated crosstalk with lysosomes reciprocally aggravates mitochondrial defect through LManVI. Nature Communications. 16(1): p. 7304.
2. Ti X#, Zuo H #, Zhao G, Li Y, Du M, Xu L, Li S, Shan Z, Gao Y, Gan G *, Wang Y *, Zhang Q *. (2025) Parkin mediates the mitochondrial dysfunction through mRpL18. J Biol Chem. 301(6):110208.
3. Shan Z#, Li S#, Gao Y, Jian C, Ti X, Zuo H, Wang Y, Zhao G, Wang Y*, Zhang Q*. (2024) mtDNA extramitochondrial replication mediates mitochondrial defect effects. iScience.27(2):108970.
4. Gao Y#, Shan Z#, Jian C, Wang Y, Yao X, Li S, Ti X, Zhao G, Liu C*, Zhang Q*. (2023) HIB/SPOP inhibits Ci/Gli-mediated tumorigenesis by modulating the RNA Polymerase II components stabilities. iScience.26(8):107334.
5. Zhang Q，Jiang J. (2021) Regulation of Hedgehog Signal Transduction by Ubiquitination and Deubiquitination. Int J Mol Sci. 22(24):13338.
6. Jiang W, Yao X, Shan Z, Li W, Gao Y, Zhang Q. (2019) E3 ligase Herc4 regulates Hedgehog signalling through promoting Smoothened degradation. J Mol Cell Biol. 11(9):791-803.
7. Zhou Z, Yao X, Pang S, Chen P, Jiang W, Shan Z, Zhang Q. (2018) The deubiquitinase UCHL5/UCH37 positively regulates Hedgehog signaling by deubiquitinating Smoothened. J Mol Cell Biol. 10(3):243-257.
8. Zhou Z, Yao X, Li S, Xiong Y, Dong X, Zhao Y, Jiang J, Zhang Q. (2015) Deubiquitination of Ci/Gli by Usp7/HAUSP Regulates Hedgehog Signaling. Dev Cell. 34(1):58-72.
9. An J, Ren S, Murphy S, Dalangood S, Chang C, Pang X, Cui Y, Wang L, Pan Y, Zhang X, Zhu Y, Wang C, Halling G, Cheng L, Sukov W, Karnes R, Vasmatzis G, Zhang Q, Zhang J, Cheville J, Yan J, Sun Y, Huang H. (2015) Truncated ERG Oncoproteins from TMPRSS2-ERG Fusions Are Resistant to SPOP-Mediated Proteasome Degradation. Mol Cell. 59:1-13.
10. Liu C, Zhou Z, Chen P, Su MY, Chang CJ, Yan J, Jiang J, Zhang Q. (2014) Hedgehog signaling downregulates Suppressor of Fused through the HIB/SPOP-Crn axis in Drosophila. Cell Research. 24,595-609.
11. Zhang Q, Shi Q, Chen Y, Yue T, Li S, Wang B, Jiang J. (2009) Multiple Ser/Thr-rich degrons mediate the degradation of Ci/Gli by the Cul3-HIB/SPOP E3 ubiquitin ligase. PNAS . 106(50):21191-6.
12. Zhang L, Ren F, Zhang Q, Chen Y, Wang B, Jiang J. (2008) The TEAD/TEF Family of Transcription Factor Scalloped Mediates Hippo Signaling in Organ Size Control. Dev Cell. 14, 377-387.
13. Zhang Q, Zhang L, Wang B, Ou CY, Chien CT, Jiang J. (2006) A Hedgehog-induced BTB protein modulates Hedgehog signaling responses by degrading Ci/Gli transcription factor. Dev Cell. 10, 719-729.
14. Jia J, Zhang L, Zhang Q, Tong C, Wang B, Hou F, Amanai K, Jiang J. (2005) Phosphorylation of Cubitus interruptus by Double-time/CKIe and CKIa targets it for Slimb/b-TRCP mediated proteolytic processing. Dev Cell. 9, 819-830.