南京市栖霞区南京大学仙林校区生命科学学院
chengliangwang@nju.edu.cn
18709831375工作经历
2026.02-至今 南京大学生命科学学院 至诚青年教授/特聘研究员
2026.02- 至今 南京大学化学和生物医药创新研究院 特聘研究员
2020.05-2026.02 美国康涅狄格大学健康中心，免疫学，博士后（合作导师：Prof. Jianbin Ruan）
2018.05-2020.05 美国伊利诺伊大学厄巴纳-香槟分校，生物化学与分子生物学，博士后（合作导师：Prof. Hong Jin）
2015.06-2018.05 中国科学技术大学，生物化学与分子生物学，博士后（合作导师：臧建业教授）
荣誉奖励
2025 国家优青（海外）
2025 江苏省特聘教授
学术任职
代表性成果
1.Chengliang Wang, Sonia Shivcharan, Tian Tian, et al. Structural basis for GSDMB pore formation and its targeting by IpaH7.8. Nature (2023)：616, 590–597.
2.Chengliang Wang#, Philip Lacey#, Tian Tian#, Evelyn Teran, Maham Liaqat, Sonia Shivcharan, Patience Shumba, Jie He, Vijay A Rathinam, Vicki H Wysocki, and Jianbin Ruan, LPS-induced structural reorganization and polymerization drive non-canonical inflammasome activation. Science Advances (2026): 12 (1), eadz4623. (# authors contributed equally)
3.Chengliang Wang, Brooke Dreyer, Evelyn Teran, Jianbin Ruan.From pores to rupture: structural basis and regulation of lytic cell death by gasdermins and NINJ1. J. Biol. Chem. (2025): 301(10), 110698.
4.Chengliang Wang, Jianbin Ruan., An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis. PLoS biology (2023): 21 (5), e3002103.
5.Chengliang Wang, Jianbin Ruan, Mechanistic Insights into Gasdermin Pore Formation and Regulation in Pyroptosis. Journal of Molecular Biology, 434 (2021):167297
6.Chengliang Wang#, Minhao Wu#, Li Zhan#, Rongsheng Ma, Jun Yao,Ying Xiong, Yang Pan, Xuan Zhang, Jianye Zang, Spindlin‐1 recognizes methylations of K20 and R23 of histone H4 tail. FEBS letters(2018): 592 (24), 4098-4110. (# represents co-first authorship).
7.Xing Zhou#, Fan Zheng#, Chengliang Wang#, Minhao Wu, Xiaozhen Zhang, Qian Wang, Xuebiao Yao, Chuanhai Fu, Xuan Zhang and Jianye Zang, Phosphorylation of CENP-C by Aurora B promotes kinetochore attachment error correction in mitosis.Proc Natl Acad Sci USA. 2017 Dec 12;114(50): E10667-E10676. (# represents co-first authorship
8.Wang , Chengliang; Zhang, Qiongdi; Hang, Tianrong; Tao, Yue; Ma, Xukai; Wu, Minhao; Zhang, Xuan; Zang, Jianye, Structure of the JmjC domain-containing protein NO66 complexed with ribosomal protein Rpl8, Acta Crystallographica Section D-Biological Crystallography, (2015): 71, pp 1955-1964.
9.Evelyn Teran#, Tian Tian# , Chengliang Wang , Xinzheng Wang , Jinghan Wang, Dongchun Ni, Vijay A Rathinam, and Jianbin Ruan，Structural basis and regulation of GSDME pore formation. Nature Communications, 2026. https://doi.org/10.1038/s41467-026-70643-5
10.Anh B Cao, Pascal Devant, Chengliang Wang, Mengyu Sun, Stephanie N Kennedy, Weiyi Ma, Jianbin Ruan, Jonathan C Kagan.LPS binding caspase activation and recruitment domains (CARDs) are bipartite lipid binding modules. Science Advances(2025):11(10), eadt9027.
11.Sonia Shivcharan, Doulathunnisa Ahamed Younis, Skylar S Wright, Chengliang Wang, Bharat Behl, Patience Shumba, Kristina N Delgado, Arshmeet K Chawla, Neal M Alto, Noorjahan Panjwani, Sivapriya Kailasan Vanaja, Jianbin Ruan, Zhichao Fan, Vijay A Rathinam,Endolysosomal damage surveillance enables rapid inflammasome sensing of pathogens. Cell Rep. 2025;44(8):116002.
12.Skylar S. Wright#, Puja Kumari#, Víctor Fraile-Ágreda, Chengliang Wang, et.al Vesicular transplantation of gasdermin pores propagates pyroptosis. Cell (2025):188, pp1–12.
13.Skylar S. Wright, Chengliang Wang, Atri Ta, Morena S. Havira, Jianbin Ruan, Vijay A. Rathinam, Sivapriya Kailasan Vanaja. A bacterial toxin co-opts caspase-3 to disable active gasdermin D and limit macrophage pyroptosis.Cell Reports (2024):43, 114004.
14.A.J. Russo, S.O. Vasudevan, S.P. MéndezHuergo, P. Kumari, A. Menoret, S. Duduskar,C.Wang, J.M. Pérez Sáez, M.M. Fettis,et al. Intracellular immune sensing promotes inflammation via gasdermin D–driven release of a lectin alarmin. Nature Immunology (2021):22, 154–165.
15.Havira, M.S.; Ta, A.; Kumari, P.; Wang, C.; Russo, A.J.; Ruan, J.; Rathinam, V.A.; Vanaja, S.K. Shiga toxin suppresses noncanonical inflammasome responses to cytosolic LPS. Science. Immunol. (2020):5, eabc0217.