工作经历
2024-,南京大学助理教授
荣誉奖励
学术任职
1. 2024-,江苏省免疫学会,衰老和免疫分会常务理事
2. 2025-,南京大学青年促进会委员
2. 2024-,Phenomics 杂志青年编委(复旦大学主办)
3. 2024-,Frontiers in Endocrinology 特约编辑
4. 2025-,Aging Advances 杂志青年编委
代表性成果
[1] Jin X, Zhou Y, Sun L, Li L, Zheng C, Shan Z, Ding C, Huang D, Zhang Q, Fan R, Sun G, Shen M, Wang H*, Huang Z*. Activation of α7nAChR reduces inflammation and apoptosis, promoting muscle regeneration through the AKT-FOXO1 pathway. Cell Death Differ. 2026 Apr 3. doi: 10.1038/s41418-026-01738-1.
[2] Lian P, Lu R, Gu C, Wazir J, Wang W, Zong Y, Xia Y, Ni J, Chen H, Petretto E, Treuter E, Fan R, Yang A, Su Z, Wang H*, Huang Z*. Gut microbiota dysbiosis-driven bile acids dysfunction alters keratinocytes lipid metabolism via FXR-NQO1 signaling in psoriasis. Nature Communications. 2026. in press
[3] Pu W, Zhang X, Tian M, He Z, Zhu J, Song S, Li L, Lian P, Lu R, Wang R, Lin K, Gu C, Wazir J, Wang C, Sun Y, Yang J, Zhang Y, Chen H, Petretto E, Cao W, Fan R, Treuter E, Zhang X, Liu N, Yang A, Chen X, Wang H*, Huang Z*. Mycobacterium tuberculosis IDH-PPARγ Interaction Suppresses GPX4 to Drive Macrophage Ferroptosis and Sustain Persistent Infection. Nature Communications. 2026 in revision
[4] Kai Lin, Lulu Wei1, Ranran Wang, Li Li, Shiyu Song, Fei Wang, Meiwei He, Wenyuan Pu, Jinglin Wang, Junaid Wazir, Wangsen Cao, Xiaozhong Yang, Eckardt Treuter, Rongrong Fan, Yongxiang Wang*, Huang Z*, Hongwei Wang*. Disrupted methionine cycle triggers muscle atrophy in cancer cachexia through epigenetic regulation of REDD1. Cell Metabolism. 2024 Dec 20:S1550-4131(24)00413-3.
[5] Astradeni Efthymiadou, Chaode Gu, Cheng Wang, Hongwei Wang, Rongrong Fan, Eckardt Treuter*, Huang Z*. SMRT anchors the HDAC3 corepressor complex to chromatin to regulate inflammatory and metabolic pathways in macrophages. Nucleic Acids Research, Nucleic Acids Research, 2025, 53, (17).
[6] Huang Z, Ning Liang, Saioa Goñi, Anastasios Damdimopoulos, Cheng Wang, Raphaelle Ballaire, Jennifer Jager, Henri Niskanen, Hongya Han, Tomas Jakobsson, Adrian P. Bracken, Myriam Aouadi, Nicolas Venteclef, Minna U. Kaikkonen, Rongrong Fan, Eckardt Treuter. The corepressors GPS2 and SMRT control enhancer and silencer remodelling linked to eRNA transcription during inflammatory activation of macrophages. Molecular Cell. (2021) doi:10.1016/j.molcel.2020.12.040.
[7] Huang Z, Ning Liang, Anastasius Damdimopoulos, Rongrong Fan, Eckardt Treuter. G-protein pathway suppressor 2 links inflammation and cholesterol efflux by controlling lipopolysaccharide-induced ATP-binding cassette transporter A1 expression in macrophages. FASEB Journal, 2019 Feb. 33(2):1631-1643.
[8] Panpan Lian, Li Li, Renwei Lu, Bin Zhang, Junaid Wazir, Chaode Gu, Bojie Ma, Wenyuan Pu, Wangsen Cao, Huang Z*, Zhonglan Su*, Hongwei Wang*. Cell Death & Disease. S1PR3-driven positive feedback loop sustains STAT3 activation and keratinocyte hyperproliferation in psoriasis. 2025 Jan 20;16(1):31.
[9] Liang N, Damdimopoulos A, Goñi S, Huang Z, Vedin LL, Jakobsson T, Giudici M, Ahmed O, Pedrelli M, Barilla S, Alzaid F, Mendoza A, Schröder T, Kuiper R, Parini P, Hollenberg A, Lefebvre P, Francque S, Van Gaal L, Staels B, Venteclef N, Treuter E, Fan R. Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα. Nature Communications, 2019 Apr 11;10(1):1684.
[10] Karima Drareni, Raphaëlle Ballaire, Serena Barilla, Mano J. Mathew, Amine Toubal, Rongrong Fan, Ning Liang, Catherine Chollet, Huang Z, Maria Kondili, Fabienne Foufelle, Antoine Soprani, Ronan Roussel, Jean-François Gautier, Fawaz Alzaid, Eckardt Treuter, Nicolas Venteclef. GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation. Cell Reports, 2018, 24(11): 2957-2971.
[11] Rongrong Fan, Amine Toubal, Saioa Goñi, Karima Drareni, Huang Z, Fawaz Alzaid, Raphaelle Ballaire, Patricia Ancel, Ning Liang, Anastasios Damdimopoulos, Isabelle Hainault, Antoine Soprani, Judith Aron-Wisnewsky, Fabienne Foufelle, Toby Lawrence, Jean-Francois Gautier, Nicolas Venteclef, Eckardt Treuter. Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes. Nature Medicine, 2016, 22(7):780-91.
[12] Eckardt Treuter, Rongrong Fan, Huang Z, Tomas Jakobsson, and Nicolas Venteclef. Transcriptional repression in macrophages-basic mechanisms and alterations in metabolic inflammatory diseases. FEBS Letters, 2017, 591: 2959-2977.